Smectite in the Treatment of Acute Diarrhea: A Nationwide Randomized Controlled Study of the Italian Society of Pediatric Gastroenterology and Hepatology (SIGEP) in Collaboration With Primary Care Pediatricians

Abstract

Smectite reduces the duration of diarrhea and prevents a prolonged course. It may therefore consistently reduce the costs of gastroenteritis.

Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders

“…Moreover, montmorillonite can coat the gastrointestinal mucosa and consequently improve the defensive function against aggressive factors (Yen, 2006). Montmorillonite is recommended as an over-the-counter medicine for treating acute and chronic diarrhea and irritable bowel syndrome (IBS), owing to its strong adsorption (Guarino et al, 2001, Ducrotte et al, 2005). In our previous study, we demonstrated that montmorillonite adsorbs dietary triglycerides and cholesterol and increases fecal lipid excretion, thereby preventing obesity in an HFD-fed rat model (Xu et al, 2016).…”

Caracterización, influencia y manipulación de la microbiota gastrointestinal en salud y enfermedad

“…Aunque la mayoría de las investigaciones con estas arcillas se han centrado en sus efectos para prevenir la intoxicación por aflatoxinas 195,196 , estas arcillas han demostrado su utilidad en el tratamiento de signos clínicos GI. Por ejemplo, un estudio en Italia de más de 800 niños con diarrea aguda mostró que una arcilla de tipo esmectita redujo significativamente la duración de la diarrea 197 . Investigaciones más recientes han confirmado este efecto benéfico de arcillas esmectitas en controlar la diarrea en un gran número de pacientes pediátricos 198 .…”

Drug release characteristics from nanoclay hybrids and their dispersions in organic polymers

“…pregnancy (Dong and Feng, 2005;Guarino et al, 2001). Hydrotalcite, an anionic nanoclay -from the family of layered double hydroxides (LDHs) -is a popular antacid and is used because magnesium and aluminum metal oxides slowly hydrolyze regulating the pH to an optimum value without provoking a rebound effect in the stomach (Linares and Brikgi, 2006).…”