Smartphone-imaged multilayered paper-based analytical device for colorimetric analysis of carcinoembryonic antigen

Wang, Kan; Yang, Jin; Xu, Hao; Cao, Bo; Qin, Qi; Liao, Xinmei; Yan, Wei; Jin, Qinghui; Cui, Daxiang

doi:10.1007/s00216-020-02475-1

Cited by 54 publications

(33 citation statements)

References 49 publications

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“…Li et al 128 proposed a two-layer microfluidic paper-based device with multiple colorimetric indexes for the simultaneous detection of four small biomolecules (glucose, uric acid, lactic acid and choline) within the same mixture (Figure 3C). Wang et al 129 developed a wax-printed multilayer paper-based microfluidics detection sensor for colorimetric detection of carcinoembryonic antigen.…”

Section: Diagnosismentioning

confidence: 99%

Paper-based sensors for diagnostics, human activity monitoring, food safety and environmental detection

et al. 2022

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Section: Diagnosismentioning

confidence: 99%

Paper-based sensors for diagnostics, human activity monitoring, food safety and environmental detection

et al. 2022

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“…Furthermore, the charge recombination is reduced that accompanied by a higher intensity resolution [73a,82a, 84] . Despite an inorganic‐based biosensor, colorimetric biosensor can also be an organic‐derived one by involving organic substrate such as nematic LC 4‐cyano‐4′‐pentylbiphenyl (5CB), [78b] and glutaraldehyde [85] . After all, the suitable signal measurement is by optical density in relating the number of analytes with the intensity of the colour.…”

Section: The Nanomaterial‐based Cea (Colorimetric‐based and Chemilumi...mentioning

confidence: 99%

“…The selectivity of the sensing probe can be achieved by having the antigen‐antibody immunoassay [73a,77–78,80a–c,82a,83–86] or aptamer‐labelled biosensor [78d,79,80d,81] . Nevertheless, the labelled free system [78d,85] is suggested to overcome the shortcoming of labelled one as aptasensor that utilises the single‐stranded oligonucleotides chain as biorecognition site with an improved affinity towards analyte. The modifications of both the labelled and non‐labelled sensing probes are illustrated as follows.…”

Section: The Nanomaterial‐based Cea (Colorimetric‐based and Chemilumi...mentioning

confidence: 99%

Recent Advances in Nanomaterial‐based Optical Biosensors as Potential Point‐of‐Care Testing (PoCT) Probes in Carcinoembryonic Antigen Detection

Lee

Pandian

et al. 2022

Chemistry An Asian Journal

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For the past decades, several cancer biomarkers have been exploited for rapid and accurate prognosis or diagnosis purposes. In this review, the optical biosensor is targeted for carcinoembryonic antigen (CEA) detection. The CEA level is a prominent parameter currently used in clinical cases for the prognosis of cancer-related diseases. Many nanomaterial-based biosensors are invented as alternatives for the commonly used enzyme-linked immunosorbent assays (ELISA) immunoassay method in CEA detection as the traditional approach. But they possess certain drawbacks such as tedious procedure, high technical demand, and costly. Nevertheless, the effort appears to be wasted as none of them are being actualised. Generally, the sensor function was carried out by converting bio-signals generated upon the interface of the receptor into light signals. These sensors were popular due to specific advantages such as sensitivity, being free from chemical and electromagnetic interferences, wide dynamic range, and being easy to be monitored. The features of PoC diagnostics are discussed and associated to the various applications of colorimetric-based and chemiluminescent-based biosensors. The roles of nanomaterials in each application were also summarised by comparing the modification, incubation period, lowest detection limit (LOD) and linear range of detection amount. The challenges and future perspectives were highlighted as well at the end of the review.

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“…The intensity of a color signal can be interpreted using imaging software, where a pixel value is related to the concentration of the analyte. The data can be analyzed by using such a system [ 129 , 130 , 131 , 132 ].…”

Section: Detection Techniquesmentioning

confidence: 99%

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

et al. 2020

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Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabricated, disposable, and portable. Because of our better understanding and advanced engineering of µPADs, multistep assays, high detection sensitivity, and rapid result readout have become possible, and recently developed µPADs have gained extensive interest in parallel analyses to detect biomarkers of interest. In this review, we focus on recent developments in order to achieve µPADs with high-throughput capability. We discuss existing fabrication techniques and designs, and we introduce and discuss current detection methods and their applications to multiplexed detection assays in relation to clinical diagnosis, drug analysis and screening, environmental monitoring, and food and beverage quality control. A summary with future perspectives for µPADs is also presented.

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Smartphone-imaged multilayered paper-based analytical device for colorimetric analysis of carcinoembryonic antigen

Cited by 54 publications

References 49 publications

Paper-based sensors for diagnostics, human activity monitoring, food safety and environmental detection

Paper-based sensors for diagnostics, human activity monitoring, food safety and environmental detection

Recent Advances in Nanomaterial‐based Optical Biosensors as Potential Point‐of‐Care Testing (PoCT) Probes in Carcinoembryonic Antigen Detection

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

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