Smartphone-based point-of-care testing of the SARS-CoV-2: A systematic review

Zayed, Berlanty A.; Ali, Ahmed N.; Elgebaly, Alaa A.; Talaia, Nourhan M.; Hamed, Mahmoud; Mansour, Fotouh R.

doi:10.1016/j.sciaf.2023.e01757

Cited by 2 publications

(1 citation statement)

References 61 publications

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“…RT-PCR is considered the gold standard for diagnoses like pneumonia. While RT-PCR stands out for its sensitivity, precision, and specificity in identifying viruses, it still has limitations, such as sample storage issues [ 39 , 40 ], contamination from external aerosols [ 38 ], long waiting periods [ 40 ], the need for large equipment [ 41 ], and professional requirements for the operators [ 39 , 41 , 42 ].…”

Section: The Application Of Pcr Technology In Microfluidic Platformsmentioning

confidence: 99%

Advances in Nucleic Acid Assays for Infectious Disease: The Role of Microfluidic Technology

Wang,

Chen,

Yang

et al. 2024

Molecules

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Within the fields of infectious disease diagnostics, microfluidic-based integrated technology systems have become a vital technology in enhancing the rapidity, accuracy, and portability of pathogen detection. These systems synergize microfluidic techniques with advanced molecular biology methods, including reverse transcription polymerase chain reaction (RT-PCR), loop-mediated isothermal amplification (LAMP), and clustered regularly interspaced short palindromic repeats (CRISPR), have been successfully used to identify a diverse array of pathogens, including COVID-19, Ebola, Zika, and dengue fever. This review outlines the advances in pathogen detection, attributing them to the integration of microfluidic technology with traditional molecular biology methods and smartphone- and paper-based diagnostic assays. The cutting-edge diagnostic technologies are of critical importance for disease prevention and epidemic surveillance. Looking ahead, research is expected to focus on increasing detection sensitivity, streamlining testing processes, reducing costs, and enhancing the capability for remote data sharing. These improvements aim to achieve broader coverage and quicker response mechanisms, thereby constructing a more robust defense for global public health security.

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