Analytical Methods for the Determination of Quercetin and Quercetin Glycosides in Pharmaceuticals and Biological Samples

Mansour, Fotouh R.; Abdallah, Inas A.; Bedair, Alaa; Hamed, Mahmoud

doi:10.1080/10408347.2023.2269421

Cited by 8 publications

(5 citation statements)

References 228 publications

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“…Quercetin (3,3 ′ ,4 ′ ,5,7-pentahydroxyflavone), a flavonol derived from various vegetables and fruits [171], has exhibited anti-angiogenesis properties viamodulation of the AKT/mTOR/P70S6K signaling cascade regulated by VEGFR2 [73]. It also hinders MMP-2 and MMP-9 signaling through curbing the MAPK and PI3K/AKT signaling cascades [74].…”

Section: Flavonolmentioning

confidence: 99%

Flavonoids with Anti-Angiogenesis Function in Cancer

Wei,

Zhang

2024

Molecules

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The formation of new blood vessels, known as angiogenesis, significantly impacts the development of multiple types of cancer. Consequently, researchers have focused on targeting this process to prevent and treat numerous disorders. However, most existing anti-angiogenic treatments rely on synthetic compounds and humanized monoclonal antibodies, often expensive or toxic, restricting patient access to these therapies. Hence, the pursuit of discovering new, affordable, less toxic, and efficient anti-angiogenic compounds is imperative. Numerous studies propose that natural plant-derived products exhibit these sought-after characteristics. The objective of this review is to delve into the anti-angiogenic properties exhibited by naturally derived flavonoids from plants, along with their underlying molecular mechanisms of action. Additionally, we summarize the structure, classification, and the relationship between flavonoids with their signaling pathways in plants as anti-angiogenic agents, including main HIF-1α/VEGF/VEGFR2/PI3K/AKT, Wnt/β-catenin, JNK1/STAT3, and MAPK/AP-1 pathways. Nonetheless, further research and innovative approaches are required to enhance their bioavailability for clinical application.

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Section: Flavonolmentioning

confidence: 99%

Flavonoids with Anti-Angiogenesis Function in Cancer

Wei,

Zhang

2024

Molecules

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“…One conceivable reason is that β-glycosidase enzymes hydrolyse quercetin glycosides, converting them to aglycone. Most of these enzymes are found in the GI tract, where the enzymes are then absorbed [24].…”

Section: Pharmacokinetics Of Quercetinmentioning

confidence: 99%

Preclinical Therapeutic Effects of Quercetin on Gastrointestinal Cancers

Xin Jie Tune,

Seng Wu,

Mac Guad

et al. 2024

Quercetin - Effects on Human Health [Working Title]

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Gastrointestinal (GI) cancers were included in the top 10 most common cancers in 2020. Future incidences are expected to rise due to the varying risk factors and aetiologies. With high incidences and mortality rates, current cancer treatments fail to reduce mortality and morbidity in GI cancer patients. A large part of cancer research has been geared towards targeted and personalized medicine, although effective, it may not be the most cost-friendly and feasible option to treat patients from varying socioeconomic backgrounds. Hence, natural compounds may present as an attractive alternative treatment in the management of GI cancers. Quercetin is a well-known flavonoid compound, found in almost all fruits and vegetables. It has also been widely studied for its anticancer properties, such as anti-oxidative, anti-inflammatory, anti-proliferative and anti-angiogenic properties. In this chapter, the authors discuss the potential of quercetin in treating GI cancers, which includes the biosafety and toxicity of quercetin, applications of quercetin in common GI cancers, such as gastric, hepatic, colorectal, pancreatic and oesophageal cancers, along with the corresponding molecular mechanisms. The authors also present evidences of quercetin as an adjuvant therapeutic agent with other anticancer drugs.

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“…In Table 2, it is shown all the techniques that they were used for the encapsulation of quercetin in macromolecules. [156].…”

Section: Additive Treatment Of Diseasementioning

confidence: 99%

Quercetin: A Potential Polydynamic Drug

Georgiou,

Kakava,

Routsi

et al. 2023

Molecules

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The study of natural products as potential drug leads has gained tremendous research interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and, more specifically, flavonols. This review summarizes the beneficial pharmaceutical effects of quercetin, such as its anti-cancer, anti-inflammatory, and antimicrobial properties, which are some of the quercetin effects described in this review. Nevertheless, quercetin shows poor bioavailability and low solubility. For this reason, its encapsulation in macromolecules increases its bioavailability and therefore pharmaceutical efficiency. In this review, a brief description of the different forms of encapsulation of quercetin are described, and new ones are proposed. The beneficial effects of applying new pharmaceutical forms of nanotechnology are outlined.

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Analytical Methods for the Determination of Quercetin and Quercetin Glycosides in Pharmaceuticals and Biological Samples

Cited by 8 publications

References 228 publications

Flavonoids with Anti-Angiogenesis Function in Cancer

Flavonoids with Anti-Angiogenesis Function in Cancer

Preclinical Therapeutic Effects of Quercetin on Gastrointestinal Cancers

Quercetin: A Potential Polydynamic Drug

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