Smartphone application for captopril determination in dosage forms and synthetic urine employing digital imaging

Ravazzi, Caroline Gomes; Franco, Mathews de Oliveira Krambeck; Vieira, Maria Carolina Robaina; Suarez, Willian Toito

doi:10.1016/j.talanta.2018.07.015

Cited by 30 publications

(9 citation statements)

References 28 publications

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“…Blue channel response provided the highest sensitivity and linearity because the absorption of yellow products mostly absorbs the violet light (Blue and Red channel). 32 We hence selected this channel for the next experiment. The experimental result is related to the spectrum from the UV-Visible spectrophotometer of an occurred product, as indicated in Figure. S1.…”

Section: Principle Of Proposed Technique and Its Acquisitionmentioning

confidence: 99%

A Portable Reflective Absorbance Spectrophotometric Smartphone Device for the Rapid and Highly Accurate Determination of Amlodipine in Pharmaceutical Formulation and Human Urine Samples

Khachornsakkul

Dungchai

2020

ANAL. SCI.

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The simple reflective absorbance spectrophotometric smartphone device for point-ofmonitoring amlodipine is presented here for the first time. The immediate analysis of amlodipine in the human urine of the patients who suffered severe side effects of this drug is very important for diagnosis, treatment, and reduction of the death rate. This measurement technique is based on the charge-transfer complex between amlodipine and picric acid, which forms a yellow product. This product can absorb light intensity from an LED strip and measure through the Blue channel from RGB mode with a smartphone application. The linear relationship for amlodipine monitoring was found in a wide range from 100.0 µg L-1 to 140.0 mg L-1 (R 2 = 0.999), and the limit of detection was found to be 25.0 µg L-1. Our proposed method can be applied to the different smartphone brands with consistent sensitivity of amlodipine detection. Additionally, the determination of amlodipine in pharmaceutical formulation and human urine samples was demonstrated by our proposed method. The recoveries were indicated in the range 98.60-100.00%, which is at the acceptable level for pharmacy. This method offers interweave of basic technology and chemical analysis with environmentally friendly due to reducing the complex instrument and the amount of organic waste compared to chromatographic technique and efficient use for the detection of amlodipine. Hence, this method can be applied for promptly medical diagnoses and laboratories with limited budget resources.

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Section: Principle Of Proposed Technique and Its Acquisitionmentioning

confidence: 99%

A Portable Reflective Absorbance Spectrophotometric Smartphone Device for the Rapid and Highly Accurate Determination of Amlodipine in Pharmaceutical Formulation and Human Urine Samples

Khachornsakkul

Dungchai

2020

ANAL. SCI.

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“…The number of molecules (n X =n NO2 ) can be determined with the Griess-Saltzman reagent, which reacts with NO 2 to form a purple azo product (Saltzman 1954). In the last decade, new measurement techniques employing digital image-based (DIB) procedures have been reported for color determination (da Silva and Borges 2019; Kiliç et al 2018;Moraes et al 2014;Passaretti Filho et al 2015;Ravazzi et al 2018;Šafranko et al 2018). The technique was recently used to speed up the determination of ozone with a passive sampler (Cerrato-Alvarez et al 2020;Garcia et al 2014).…”

Section: Introductionmentioning

confidence: 99%

A Simple Technique Based on Digital Images for Determination of Nitrogen Dioxide in Ambient Air

Souza

Neto

Cardoso

2021

Water Air Soil Pollut

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The lockdown to prevent the coronavirus spread resulted in an immediate reduction in gas concentration worldwide. This fact shows the importance of nitrogen dioxide as a pollutant gas directly associated with human activities. For indoor exposure, NO 2 has been associated with effects on the respiratory system. In outdoor environments, ozone reaches a maximum after NO 2 peaks, and acid rain arises with NO 2 oxidation to forms nitric acid. Therefore, monitoring the NO 2 concentration in atmospheric air can help prevent respiratory diseases and lower the concentration of other atmospheric pollutants. The experiment proposed in this article uses a low-cost passive sampler for the NO 2 collection. An innovative and straightforward technique to determine the gas concentration through a gel-dyed formation and based on digital image analysis RGB colors channel are split by the software ImageJ. Results of digital image analysis and spectrophotometry were statistically agreed at a 95% confidence level. The advantages of the technique include low cost, the ready availability of components, ease of use, and sensitivity. The achievable resolution of nitrogen dioxide concentrations is 9 ppb for 24-h sampling. Supplementary Information The online version contains supplementary material available at 10.1007/s11270-021-05031-4.

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“…By evaluating the works that used smartphones for image acquisition and performed the external processing of the acquired data (Figure 1), we can see that these devices are explored in several areas, such as the detection of diseases and markers of diseases causing in the medical field, immunoassay, 18–27 quality control of the environment, 28–39 forensic analysis, 40–42 control and quality of beverages and food, 15,43–64 quality evaluation of pharmaceutical products, 54,65,66 fuel quality control, 67,68 pigments, 69 chemical education, kinetic studies, and chemical receptors 70–77 …”

Section: Introductionmentioning

confidence: 99%

“…From 2011, the use of these devices begins to be more explored, and the first applications for image processing on the phone itself were reported. [14][15][16][17] By evaluating the works that used smartphones for image acquisition and performed the external processing of the acquired data (Figure 1), we can see that these devices are explored in several areas, such as the detection of diseases and markers of diseases causing in the medical field, immunoassay, [18][19][20][21][22][23][24][25][26][27] quality control of the environment, [28][29][30][31][32][33][34][35][36][37][38][39] forensic analysis, [40][41][42] control and quality of beverages and food, 15, quality evaluation of pharmaceutical products, 54,65,66 fuel quality control, 67,68 pigments, 69 chemical education, kinetic studies, and chemical receptors. [70][71][72][73][74][75][76][77] In ...…”

Section: Introductionmentioning

confidence: 99%

PhotoMetrix and colorimetric image analysis using smartphones

Böck

Helfer

Costa

et al. 2020

Journal of Chemometrics

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The steady advances in technology employed in smartphones, coupled with the high availability and the ease access to these devices, increased the interest in applying it to analytical purposes. The main goal is to develop simple, fast, and low-cost analytical methods, generating immediate results. Different analytical strategies using smartphones have been proposed to identify or determine different analytes in a wide range of matrices. Some of them use the smartphone to capture the images, to process them, and to provide the analytical results. Others use this device just for image acquisition. In this context, this review aimed to relate previous works that used smartphones to acquire images for analytical purposes, with a special focus on PhotoMetrix application, which is a tool for chemical analysis. This application allows the decomposition of digital images acquired by smartphone cameras and to process them within the same device, allowing in situ chemical analysis.

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Smartphone application for captopril determination in dosage forms and synthetic urine employing digital imaging

Cited by 30 publications

References 28 publications

A Portable Reflective Absorbance Spectrophotometric Smartphone Device for the Rapid and Highly Accurate Determination of Amlodipine in Pharmaceutical Formulation and Human Urine Samples

A Portable Reflective Absorbance Spectrophotometric Smartphone Device for the Rapid and Highly Accurate Determination of Amlodipine in Pharmaceutical Formulation and Human Urine Samples

A Simple Technique Based on Digital Images for Determination of Nitrogen Dioxide in Ambient Air

PhotoMetrix and colorimetric image analysis using smartphones

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