SmartPDT®: Smartphone enabled real-time dosimetry via satellite observation for daylight photodynamic therapy

Abstract

Background: Actinic keratosis (AK) affects one quarter of over 60 year olds in Europe with the risk of transforming into invasive squamous cell carcinoma. Daylight photodynamic therapy (dPDT) is an effective and patient preferred treatment that uses sunlight to clear AK. Currently, there is no standardised method for measuring the light received during treatment. Methods: SmartPDT® is a smartphone-based application and web-portal, developed by siHealth Ltd, enabling remote delivery of dPDT. It uses satellite imagery and computational algorithms to provide real-time determination of exposure to PpIX-effective solar radiation ("light dose"). The application also provides forecast of expected radiant exposures for 24-and 48-hs prior to the treatment period. Validation of the real-time and forecasted radiant exposure algorithms was performed against direct ground-based measurement under all weather conditions in Chilton, UK. Results: Agreement between direct ground measurements and satellite-determined radiant exposure for 2-h treatment was excellent at −0.1 % ± 5.1 % (mean ± standard deviation). There was also excellent agreement between weather forecasted radiant exposure and ground measurement, 1.8 % ± 17.7 % at 24-hs and 1.6 % ± 25.2 % at 48-hs. Relative Root Mean Square of the Error (RMSE r) demonstrated that agreement improved as time to treatment reduced (RMSE r = 22.5 % (48-hs), 11.2 % (24-hs), 5.2 % (real-time)). Conclusion: Agreement between satellite-determined, weather-forecasted and ground-measured radiant exposure was better than any existing published literature for dPDT. The SmartPDT® application and web-portal has excellent potential to assist with remote delivery of dPDT, an important factor in reducing risk in an elderly patient population during the Covid-19 pandemic.

Telehealth Use in Geriatrics Care during the COVID-19 Pandemic—A Scoping Review and Evidence Synthesis

“…Avoid over-crowding in health facilities [46] Reduction in long distance travel [46] Minimize risk of serious events such as falls [46] Improve resilience and well-being [47,48] Able to perform an assessment in the living (ecological) environment [46,[49][50][51] Service patients from rural communities [52,53] Reduce secondary and tertiary infections [54] Reduce loss to follow up [55] W-Weaknesses Difficult to treat patients with cognitive impairment, visual acuity issues, and hearing problems [56,[60][61][62][63][64] Gauging patient comprehension by providers [65,66] Limitation in physical examination including gait assessment [66][67][68] Lack of older people's inclusion in the design and user-testing of telehealth interventions [56,61] Greater risk of treatment withdrawal and increased risk of hospitalization [69] Holistically manage dementia [52,56] Personalized management including reminders [53,57] Reduce caregiver involvement, including nursing home staff [52,58] Promote social connectedness among nursing home residents in particular [44,59] Management of video connectivity problems telehealth platforms [70] Maintenance of equipment, including its sanitization and the associated extra burden [55] Lack of privacy for the older person [71] Risk of missing out on clues of elder abuse due to the lack of pr...…”

Innovative digital solution supporting sun protection and vitamin D synthesis by using satellite-based monitoring of solar radiation

“…co. uk) that monitors spectral solar radiation in near real-time and with high accuracy by using Earth Observation satellite imagery without any ground sensor. HappySun® has been scientifically validated, in different spectral bands and for different applications, in collaboration with the UK Health Security Agency (formerly Public Health England) and the UK National Health Service (NHS) [22][23][24]. During the study, the app incorporated the spectral properties of the sunscreens described below, but it can incorporate the properties of any sunscreen.…”

Új eljárás a nem melanoma típusú bőrdaganatok kezelésében: „daylight” fotodinámiás terápia

“…A d-PDT otthoni alkalmazásának jelentősége már korábban is körvonalazódott, melyet a pandémia megerősített. A beteg által otthon elvégezhető kezelést segíti az okostelefonra letölthető applikáció (SmartPDT) [31]. Az alkalmazás műholdas alapú, közel valós idejű dozimetrián alapuló méréssel meghatározza a kezelés ideális napját és a szabadban eltöltendő időt.…”