Smart-phone, paper-based fluorescent sensor for ultra-low inorganic phosphate detection in environmental samples

Sarwar, Mehenur; Leichner, Jared; Naja, Ghinwa; Li, Chen-Zhong

doi:10.1038/s41378-019-0096-8

Cited by 59 publications

(32 citation statements)

References 28 publications

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“…Phosphorus (P) is present in the environment in either an inorganic or organic state. This nutrient is a life-giving element for the growth of flora and fauna, and lake ecosystems [ 41 ]. However, excessive amounts of inorganic phosphate (I-PO 4 ) are among the main causes of growth and propagation of harmful algae known as eutrophication [ 42 ] of surface waters.…”

Section: Water Contaminantsmentioning

confidence: 99%

A Review of Nanocomposite-Modified Electrochemical Sensors for Water Quality Monitoring

Kanoun

Lazarević‐Pašti

Pašti

et al. 2021

Sensors

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Electrochemical sensors play a significant role in detecting chemical ions, molecules, and pathogens in water and other applications. These sensors are sensitive, portable, fast, inexpensive, and suitable for online and in-situ measurements compared to other methods. They can provide the detection for any compound that can undergo certain transformations within a potential window. It enables applications in multiple ion detection, mainly since these sensors are primarily non-specific. In this paper, we provide a survey of electrochemical sensors for the detection of water contaminants, i.e., pesticides, nitrate, nitrite, phosphorus, water hardeners, disinfectant, and other emergent contaminants (phenol, estrogen, gallic acid etc.). We focus on the influence of surface modification of the working electrodes by carbon nanomaterials, metallic nanostructures, imprinted polymers and evaluate the corresponding sensing performance. Especially for pesticides, which are challenging and need special care, we highlight biosensors, such as enzymatic sensors, immunobiosensor, aptasensors, and biomimetic sensors. We discuss the sensors’ overall performance, especially concerning real-sample performance and the capability for actual field application.

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Section: Water Contaminantsmentioning

confidence: 99%

A Review of Nanocomposite-Modified Electrochemical Sensors for Water Quality Monitoring

Kanoun

Lazarević‐Pašti

Pašti

et al. 2021

Sensors

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show abstract

“…A non-linear calibration function was reported along with an interference study, showing moderate phosphate selectivity. In another work, a smartphone, paper-based fluorescent sensor for ultra-low inorganic phosphate detection was reported for P detection where a reflection-mode fluorescence-sensing apparatus was developed using the fluorophore, N-[2-(1-maleimidyl)ethyl]-7-(diethylamino)-coumarin-3-carboxamide (MDCC), bound to a bacterial phosphate binding protein to generate fluorescent optical signal proportional to the concentration of phosphate [141]. The developed sensor exhibited linear detection range from 1.1 to 64 ppb.…”

Section: ) P Detectionmentioning

confidence: 99%

Sensing Methodologies in Agriculture for Soil Moisture and Nutrient Monitoring

Kashyap

Kumar

2021

IEEE Access

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Development and deployment of sensing technologies is one of the main steps in achieving sustainability in crop production through precision agriculture. Key sensing methodologies developed for monitoring soil moisture and nutrients with recent advances in the sensing devices reported in literature using those techniques are overviewed in this article. The soil moisture determination has been divided into four main sections describing soil moisture measurement metrics and laboratory-based testing, followed by in-situ, remote and proximal sensing techniques. The application, advantages and limitations for each of the mentioned technologies are discussed. The nutrient monitoring methods are reviewed beginning with laboratory-based methods, ion-selective membrane based sensors, bio-sensors, spectroscopy-based methods, and capillary electrophoresis-based systems for inorganic ion detection. Attention has been given to the core principle of detection while reporting recent sensors developed using the mentioned concepts. The latest works reported on the different sensing methodologies point towards the trend of developing low-cost, easy to use, field-deployable or portable sensing systems aimed towards improving technology adoption in crop production leading to efficient site-specific soil and crop management which in turn will bring us closer to reaching sustainability in the practice of agriculture.

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“…In addition to microfluidic devices, paper-based devices are widely used for POC diagnostics ( Chen et al, 2019 ; Magro et al, 2017a ; Z. Yang et al, 2018 ), pathogen detection (J. R. Choi et al, 2015 ), food safety analysis ( Liu et al, 2019 ; Trinh et al, 2019 ), and environmental monitoring ( Sarwar et al, 2019 ; Seok et al, 2019 ; R. Tang et al, 2017b ). Paper-based devices are easy to fabricate and inexpensive.…”

Section: Nucleic Acid Extraction From Human Bloodmentioning

confidence: 99%

Advances in point-of-care nucleic acid extraction technologies for rapid diagnosis of human and plant diseases

Paul

Ostermann

Wei

2020

Biosensors and Bioelectronics

118

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Global health and food security constantly face the challenge of emerging human and plant diseases caused by bacteria, viruses, fungi, and other pathogens. Disease outbreaks such as SARS, MERS, Swine Flu, Ebola, and COVID-19 (on-going) have caused suffering, death, and economic losses worldwide. To prevent the spread of disease and protect human populations, rapid point-of-care (POC) molecular diagnosis of human and plant diseases play an increasingly crucial role. Nucleic acid-based molecular diagnosis reveals valuable information at the genomic level about the identity of the disease-causing pathogens and their pathogenesis, which help researchers, healthcare professionals, and patients to detect the presence of pathogens, track the spread of disease, and guide treatment more efficiently. A typical nucleic acid-based diagnostic test consists of three major steps: nucleic acid extraction, amplification, and amplicon detection. Among these steps, nucleic acid extraction is the first step of sample preparation, which remains one of the main challenges when converting laboratory molecular assays into POC tests. Sample preparation from human and plant specimens is a time-consuming and multi-step process, which requires well-equipped laboratories and skilled lab personnel. To perform rapid molecular diagnosis in resource-limited settings, simpler and instrument-free nucleic acid extraction techniques are required to improve the speed of field detection with minimal human intervention. This review summarizes the recent advances in POC nucleic acid extraction technologies. In particular, this review focuses on novel devices or methods that have demonstrated applicability and robustness for the isolation of high-quality nucleic acid from complex raw samples, such as human blood, saliva, sputum, nasal swabs, urine, and plant tissues. The integration of these rapid nucleic acid preparation methods with miniaturized assay and sensor technologies would pave the road for the “sample-in-result-out” diagnosis of human and plant diseases, especially in remote or resource-limited settings.

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Smart-phone, paper-based fluorescent sensor for ultra-low inorganic phosphate detection in environmental samples

Cited by 59 publications

References 28 publications

A Review of Nanocomposite-Modified Electrochemical Sensors for Water Quality Monitoring

A Review of Nanocomposite-Modified Electrochemical Sensors for Water Quality Monitoring

Sensing Methodologies in Agriculture for Soil Moisture and Nutrient Monitoring

Advances in point-of-care nucleic acid extraction technologies for rapid diagnosis of human and plant diseases

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