Smart Nanomaterials

Yoshida, Mutsumi; Lahann, Joerg

doi:10.1021/nn800332g

Cited by 201 publications

(137 citation statements)

References 87 publications

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“…Other applications are anisotropy-based switching of displays, self-healing materials, or drug delivery, which have been reviewed recently. [153] Another area that has recently received a lot of attention is the use of Janus and patchy particles as autonomous swimmers, which is briefly discussed in the following section.…”

Section: Outlook: Application Of Patchy Particlesmentioning

confidence: 99%

Fabrication, Assembly, and Application of Patchy Particles

Pawar

Kretzschmar

2010

Macromol. Rapid Commun.

444

411

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The site‐specific engineering of colloidal surfaces has provided a powerful approach to pushing the boundaries of today's materials research. The resulting surface‐anisotropic and patchy particles have become the center of vital research areas, ranging from the need for large‐scale fabrication techniques to exploring new applications of these materials. This Review summarizes patchy particle fabrication techniques, including but not limited to particle and nanosphere lithography and glancing‐angle deposition. The variety of existing patchy particle fabrication techniques is revealed and the need for a scalable approach to high‐volume patchy particle production is identified. Ongoing modeling efforts describing patchy particle interactions and properties are reviewed as potential predictive tools. Research endeavors that deal with the directed assembly of patchy particles in electric and magnetic fields, as well as with supraparticular assembly through chemical interactions, are discussed. The Review is concluded with a note on the future application of patchy particles as phoretic motors.magnified image

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Section: Outlook: Application Of Patchy Particlesmentioning

confidence: 99%

Fabrication, Assembly, and Application of Patchy Particles

Pawar

Kretzschmar

2010

Macromol. Rapid Commun.

444

411

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“…-to respond to their use or environment; [3][4][5][6][7][8] They represent a current challenge in materials science. Among the wide variety of possible CAMs, we focus on materials whose mechanical properties change in response to their circumstance.…”

Section: Introductionmentioning

confidence: 99%

Stepped Moduli in Layered Composites

Tayi

Güder

et al. 2014

Adv Funct Materials

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This paper describes adaptive composites that respond to mechanical stimuli by changing their Young's modulus. These composites are fabricated by combining a shorter layer of elastic material (e.g. latex) and a longer layer of stiffer material (e.g., polyethylene and Kevlar), and fixing them together at their ends. Tension along the layered composite increases its length, and as the strain increases, the composite changes the load-bearing layer from the elastic to the stiff material. The result is a step in the Young's modulus of the composite. The characteristics of the step (or steps) can be engineered by changing the number of layers (thereby changing the number of steps in the modulus), the difference in lengths of the layers (thereby changing the range of steps), or the type of materials (thereby changing the tensile modulus at each step). For composites with more than two steps in modulus, the materials within the composites can be layered in a hierarchical structure to fit within a smaller volume, without sacrificing performance.These composites can also be used to make structures with tunable, stepped compressive moduli.For example, when a compressive force is applied axially to an elastomeric cylinder that is wrapped with the composite around its circumference, it expands laterally and applies a tensile force on the composite. An adaptation of these principles can generate an electronic sensor that can monitor the applied compressive strain. Increasing or decreasing the strain closes or opens a circuit and reversibly activates a light-emitting diode.3

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“…The properties of matter differ immensely on the nanoscale, leading to a smarter reaction toward in vivo chemical and physical changes. 22,23 In the current study, we evaluated the effects of MSc1 nanocomplex on experimental autoimmune encephalomyelitic (EAE) mice for the first time. This nanocomplex was designed based on modern nanochelating technology with a dominant affinity for iron.…”

Section: Introductionmentioning

confidence: 99%

The therapeutic effects of MSc1 nanocomplex, synthesized by nanochelating technology, on experimental autoimmune encephalomyelitic C57/BL6 mice

Fakharzadeh¹,

Sahraian²,

Hafizi³

et al. 2014

IJN

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Purpose Currently approved therapies for multiple sclerosis (MS) at best only slow down its progression. Therefore, it is necessary to utilize novel technologies in order to synthesize smart multifunctional structures. In the present study, for the first time we evaluated the therapeutic potential of MSc1 nanocomplex, which was designed based on novel nanochelating technology. Materials and methods MSc1 cell-protection capacity, with and without iron bond, was evaluated against hydrogen peroxide (H 2 O 2 )-induced oxidative stress in cultured rat pheochromocytoma-12 cells. The ability of MSc1 to maintain iron bond at pH ranges of 1–7 was evaluated. Nanocomplex toxicity was examined by estimating the intraperitoneal median lethal dose (LD 50 ). Experimental autoimmune encephalomyelitic mice were injected with MSc1 14 days after disease induction, when the clinical symptoms appeared. The clinical score, body weight, and disease-induced mortality were monitored until day 54. In the end, after collecting blood samples for assessing hemoglobin and red blood cell count, the brains and livers of the mice were isolated for hematoxylin and eosin staining and analysis of iron content, respectively. Results The results showed that MSc1 prevented H 2 O 2 -induced cell death even after binding with iron, and it preserved its bond with iron constant at pH ranges 1–7. The nanocomplex intraperitoneal LD 50 was 1,776.59 mg/kg. MSc1 prompted therapeutic behavior and improved the disabling features of experimental autoimmune encephalomyelitis, which was confirmed by decreased clinical scores versus increased body mass and 100% survival probability. It did not cause any adverse effects on hemoglobin or red blood cell count. Histopathological studies showed no neural loss or lymphocyte infiltration in MSc1-treated mice, while the hepatic iron content was also normal. Conclusion These results demonstrate that MSc1 could be a promising beneficial novel agent and has the capacity to be evaluated in further studies.

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Smart Nanomaterials

Cited by 201 publications

References 87 publications

Fabrication, Assembly, and Application of Patchy Particles

Fabrication, Assembly, and Application of Patchy Particles

Stepped Moduli in Layered Composites

The therapeutic effects of MSc1 nanocomplex, synthesized by nanochelating technology, on experimental autoimmune encephalomyelitic C57/BL6 mice

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