Smart drug carrier based on polyurethane material for enhanced and controlled DOX release triggered by redox stimulus

Yu, Chao; Tan, Xing; Xu, Zhenzhu; Zhu, Guodian; Teng, Wenqi; Zhao, Qian; Zhong, Linhao; Wu, Zhimin; Xiong, Di

doi:10.1016/j.reactfunctpolym.2020.104507

Cited by 18 publications

(14 citation statements)

References 73 publications

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“…The first stimulus (such as temperature) normally allows these drug-loaded micelles to enter cancer cells, and the second stimulus (here, enzymatic attack) causes micelles to disassemble and release the drug. Other degradation stimuli have been investigated, with the goal of developing enzymatic intracellular sensitive bio-based NIPU micelles for the release of anticancer drugs [107]. From L-tyrosine amino acid resources, few amphiphilic poly-(ester-urethane)s were synthesized, and their self-assembled nanoparticles were used as drug delivery carriers for cancer therapy [108].…”

Section: Short-term Implantsmentioning

confidence: 99%

Assessment of Bio-Based Polyurethanes: Perspective on Applications and Bio-Degradation

et al. 2022

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Among numerous synthetic macromolecules, polyurethane in its different forms has proven its sheer dominance and established a reputation as a reliable and trusted material due to its proficiency in terms of superior properties, which include: high mechanical strength and abrasion resistance, good durability, good adhesion, good thermal stability, excellent chemical and weathering resistance. Synthetic polyurethane materials are non-biodegradable, poisonous, and use petrochemical-based raw materials, which are now depleting, leading to a surge in polyurethane production costs. Bio-based polyurethanes (PU) have been synthesized by researchers in recent decades and have mostly overtaken petrochemical-based PU in terms of challenges such as solid pollution, economic effectiveness, and availability of raw materials. Enormous kinds of available bio-renewable sources as predecessors for the production of polyols and isocyanates have been explored for the development of “greener” PU materials; these bio-based polyurethanes have significant potential to be used as future PU products, with a partial or total replacement of petroleum-based polyurethanes, due to increasing concern about the environment, their relatively low cost and biodegradability. This critical review concentrates on the possibilities of renewable sources to be used for polyurethane production and gives a clear perspective on the journey, utilization, and recent advancements in the field of different bio-based polyurethane polymers that have arisen over the last decade.

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Section: Short-term Implantsmentioning

confidence: 99%

Assessment of Bio-Based Polyurethanes: Perspective on Applications and Bio-Degradation

et al. 2022

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“…The first stimulus (for example temperature) usually allows drug-loaded micelles insertion in cancer cells, and the second stimulus at intracellular level (in this case enzymatic attack) triggers micelles disassembly and final drug-release. In this regard, biobased self-assembly micelles were prepared from previously synthesized PLA-dithiodiethanol-PLA diol for redox-responsivity [ 273 ]. Obtained spherical micelles were stable at neutral pH (7.4).…”

Section: Biobased Pu For Biomedical Applicationsmentioning

confidence: 99%

Biobased polyurethanes for biomedical applications

Wendels

Avérous

2021

Bioactive Materials

207

173

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Polyurethanes (PUs) are a major family of polymers displaying a wide spectrum of physico-chemical, mechanical and structural properties for a large range of fields. They have shown suitable for biomedical applications and are used in this domain since decades. The current variety of biomass available has extended the diversity of starting materials for the elaboration of new biobased macromolecular architectures, allowing the development of biobased PUs with advanced properties such as controlled biotic and abiotic degradation. In this frame, new tunable biomedical devices have been successfully designed. PU structures with precise tissue biomimicking can be obtained and are adequate for adhesion, proliferation and differentiation of many cell's types. Moreover, new smart shape-memory PUs with adjustable shape-recovery properties have demonstrated promising results for biomedical applications such as wound healing. The fossil-based starting materials substitution for biomedical implants is slowly improving, nonetheless better renewable contents need to be achieved for most PUs to obtain biobased certifications. After a presentation of some PU generalities and an understanding of a biomaterial structure-biocompatibility relationship, recent developments of biobased PUs for non-implantable devices as well as short- and long-term implants are described in detail in this review and compared to more conventional PU structures.

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“…Biodegradable PU used in PU-DDSs production can be obtained via polyaddition [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ] or the polycondensation process [ 69 ]. IPDI, HDI, LDI, CDI, HMDI, and BDI were used as IC components in biodegradable PUs synthesis.…”

Section: Anti-cancer Drug Delivery Systems Obtained From Biodegradabl...mentioning

confidence: 99%

“…Another way to control the anti-cancer drug release is through redox-sensitive systems [ 37 , 45 , 53 , 59 , 65 ]. Redox-sensitive PU micelles, with tunable surface charge, switch abilities, and crosslinked with pH cleavable Schiff bonds, were obtained.…”

Section: Anti-cancer Drug Delivery Systems Obtained From Biodegradabl...mentioning

confidence: 99%

Biomedical Polyurethanes for Anti-Cancer Drug Delivery Systems: A Brief, Comprehensive Review

Sobczak

Kędra-Królik

2022

IJMS

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With the intensive development of polymeric biomaterials in recent years, research using drug delivery systems (DDSs) has become an essential strategy for cancer therapy. Various DDSs are expected to have more advantages in anti-neoplastic effects, including easy preparation, high pharmacology efficiency, low toxicity, tumor-targeting ability, and high drug-controlled release. Polyurethanes (PUs) are a very important kind of polymers widely used in medicine, pharmacy, and biomaterial engineering. Biodegradable and non-biodegradable PUs are a significant group of these biomaterials. PUs can be synthesized by adequately selecting building blocks (a polyol, a di- or multi-isocyanate, and a chain extender) with suitable physicochemical and biological properties for applications in anti-cancer DDSs technology. Currently, there are few comprehensive reports on a summary of polyurethane DDSs (PU-DDSs) applied for tumor therapy. This study reviewed state-of-the-art PUs designed for anti-cancer PU-DDSs. We studied successful applications and prospects for further development of effective methods for obtaining PUs as biomaterials for oncology.

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Smart drug carrier based on polyurethane material for enhanced and controlled DOX release triggered by redox stimulus

Cited by 18 publications

References 73 publications

Assessment of Bio-Based Polyurethanes: Perspective on Applications and Bio-Degradation

Assessment of Bio-Based Polyurethanes: Perspective on Applications and Bio-Degradation

Biobased polyurethanes for biomedical applications

Biomedical Polyurethanes for Anti-Cancer Drug Delivery Systems: A Brief, Comprehensive Review

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