Smart Biopolymer‐Based Multi‐Layers Enable Consecutive Drug Release Events on Demand

Abstract

molecular/cellular binding toward the coated surface. [2] Depending on the par ticular application, binding events have to be either promoted, inhibited, or enabled for a selected subset molecules or cells only. Strongly hydrated polymers, that is, polymers that efficiently bind water mole cules, for example, can be used to generate lubricious coatings; such lubricating coat ings supply a thin water film on the sub strate's surface thus reducing friction. [3] At the same time, hydrated polymer layers can also help in reducing the unwanted adhesion of proteins, fungi, or bacteria, which are all typical complications associ ated with implant materials. [4] In contrast,

Multifunctional “Janus‐Type” Bilayer Films Combine Broad‐Range Tissue Adhesion with Guided Drug Release

“…For example, conformational changes of such mucin glycoproteins in combination with transiently stabilizing agents can be employed to encapsulate a wide variety of substances (hydrophilic, hydrophobic, charged, uncharged) into mucin films and to release them into surrounding tissues upon exposure to a trigger molecule. [ 76 ] The ability of these films to accelerate wound healing combined with their bacteria repellent surface properties makes them ideal candidates to prevent postoperative infections and to boost the tissue healing process. Additionally, as an alternative to a postinjury application, multifunctional Janus‐type films could also be considered as interface materials mediating between wet tissues and artificial objects that are placed into the human body for extended time periods, e.g., wearable electronics such as glucose monitoring devices.…”

Dopamine-Mediated Biopolymer Multilayer Coatings for Modulating Cell Behavior, Lubrication, and Drug Release

“…To verify the ability of the different molecules to create multilayers by adsorbing to a surface in a sequential manner, a QCM-D measurement was employed using a qcell T-Q2 platform (3T-Analytik, Germany) and gold chips as described previously . The individual solutions required for the distinct steps of the coating process were sequentially flushed into the QCM-D chamber at a flow rate of 100 μL/min; each molecular flux was maintained for 15 min.…”

“…Biopolymer coatings can be assembled in the form of monolayers or multilayers, , from nano/micro-particles, , and as hydrogels . Biopolymer multilayers are commonly constructed using the layer-by-layer deposition technique, which typically employs an alternating deposition of cationic and anionic polyelectrolytes onto a material surface to form polyelectrolyte multilayer films (PEM) .…”

Hybrid Mucin‐Vaterite Microspheres for Delivery of Proteolytic Enzyme Chymotrypsin

“…[ 11 ] Biocompatibility and biodegradability of natural mucins further premise their use in fabrication of drug carriers. [ 11,12 ] Generally, the hybrids of mucin with other biopolymers are employed, e.g., polyethylene glycol, [ 13,14 ] gelatin, [ 15 ] alginate, [ 16 ] cellulose, [ 17 ] methylcellulose, [ 18 ] chitosan. [ 19 ]…”

“…[11] Biocompatibility and biodegradability of natural mucins further premise their use in fabrication of drug carriers. [11,12] Generally, the hybrids of mucin with other biopolymers are employed, e.g., polyethylene glycol, [13,14] gelatin, [15] alginate, [16] cellulose, [17] methylcellulose, [18] chitosan. [19] From the other side, the delivery of proteins requires the compliance with some additional prerequisites such as their protection from the degradation and preservation of their biological activity, which strictly depends on labile protein structure.…”