Abstract:Biopolymer coatings on implants mediate the interactions between the synthetic material and its biological environment. Owing to its ease of preparation and the possibility to incorporate other bioactive molecules, layer-by-layer deposition is a method commonly used in the construction of biopolymer multilayers. However, this method typically requires at least two types of oppositely charged biopolymers, thus limiting the range of macromolecular options by excluding uncharged biopolymers. Here, we present a la… Show more
“…And, indeed, there are reports in the literature suggesting that the coating thickness can influence the physical and biological properties of a coating. 40 Thus, a larger PEG variant than the PEG100 used here might have a stronger effect in reducing the cell attachment to the ETT surface. Still, for the carbodiimide-based coating strategy employed here, the PEG100 variant was the largest commercial option we could find that carries the necessary amino- (or carboxy-) modification.…”
Macromolecular coatings can improve the surface properties of many medical devices by enhancing their wetting behavior, tribological performance, and anti-biofouling properties – and covalent coatings produced from mucin glycoproteins have...
“…And, indeed, there are reports in the literature suggesting that the coating thickness can influence the physical and biological properties of a coating. 40 Thus, a larger PEG variant than the PEG100 used here might have a stronger effect in reducing the cell attachment to the ETT surface. Still, for the carbodiimide-based coating strategy employed here, the PEG100 variant was the largest commercial option we could find that carries the necessary amino- (or carboxy-) modification.…”
Macromolecular coatings can improve the surface properties of many medical devices by enhancing their wetting behavior, tribological performance, and anti-biofouling properties – and covalent coatings produced from mucin glycoproteins have...
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