Smart bioadhesives for wound healing and closure

Highly Antibacterial and Adhesive Hyaluronic Acid Hydrogel for Wound Repair

“…In addition, hydrogels prepared by a variety of hydrophilic polymers have been widely used as wound dressings due to their flexibility and porosity, which can provide a good healing environment for infected wounds. , Especially, natural polymers such as peptides, gelatins, and polysaccharides exhibit a higher affinity and biocompatibility for biological tissues. Hyaluronic acid (HA) as a natural polysaccharide in connective tissues plays an important role in tissue regeneration and angiogenesis, which provides favorable conditions for wound healing by reducing inflammation and enhancing collagen deposition, so HA-based hydrogels have been widely developed for hydrogel dressings. − However, although HA-based hydrogels have many benefits for wound closure, they present a weak adhesive property to adhere to the tissue surface. − Recently, dopamine inspired by mussel proteins has received great attention due to its remarkable adhesion, where the catechol groups adhere to various surfaces through the formation of reversible noncovalent or irreversible covalent interactions. , For instance, Desai et al used dopamine to chemically modify elastin-like polypeptides (ELPs) to synthesize adhesive proteins; the catechol-functional ELPs or Cat-ELPs can form flexible hydrogels for wound closure . The introduction of dopamine in HA hydrogels will endow the wound dressing with good biological adhesive properties, benefiting for the wound repair. , To the best of our knowledge, there are few cases on adhesive hydrogel dressings bearing photosensitizer units to improve the photodynamic antimicrobial efficacy and promote wound healing simultaneously.…”

Functional Asymmetry-Enabled Self-Adhesive Film via Phase Separation of Binary Polymer Mixtures for Soft Bio-Integrated Electronics

“…A soft adhesive film was produced by the inflow of HA, and fine wrinkles were observed in the shape of the adhesive surface (Figure 2a (4)), which possibly resulted from interfacial instability caused by water evaporation from the mixed solution during the curing process. 33−35 Figure 2a (6) shows an image of a film that was pulled after attaching it to the skin to demonstrate the adhesion between the film and skin. In addition, we also compared the stress−strain behavior of the PDMS/HA composite film with that of PDMS-based elastomers with different mixing ratios between the cross-linking agent and silicone base.…”

“…Smart bioadhesion has received considerable attention in the field of biointegrated electronics, including e-skin, e-tattoos, deformable sensors, and bioelectrodes. − For the development of such bioadhesives, extensive investigations have been made concerning materials and structures that can provide tunable mechanical properties and adhesion. The commonly reported processing method of synthetic bioadhesives ensures isotropic adhesion by applying various fabrication methods including cross-linking density control, side-group modification for covalent or noncovalent interactions, and introduction of dual-networking. − However, in the case of isotropic adhesion, the exposed adhesive component can easily collect impurities, thereby causing problems in practical applications, such as the instability of signal acquisition and poor anti-interference ability. − Therefore, the development of asymmetric films with adhesiveness on only one side should be considered.…”

Construction of multifunctional wound dressings with their application in chronic wound treatment

“…26 Cheng et al summarized smart bioadhesives for wound healing and closure. 27 Unfortunately, a detailed summary and systematic analysis about the research progress of multifunctional wound dressings in recent years is still lacking. Based on the research experience of our group on wound dressings for chronic wound treatment and the relevant progress in recent years, this paper systematically discussed different types of wound dressings with anti-inflammatory/antioxidant activity, antibacterial properties, pro-angiogenic function, and tissue adhesion.…”