Small Vessel Replacement by Human Umbilical Arteries With Polyelectrolyte Film-Treated Arteries

Kerdjoudj, Halima; Berthélémy, Nicolas; Rinckenbach, Simon; Kearney‐Schwartz, Anna; Montagne, Karine; Schaaf, Pierre; Lacolley, Patrick; Stoltz, Jean‐François; Voegel, Jean‐Claude; Menu, Patrick

doi:10.1016/j.jacc.2008.08.009

Cited by 58 publications

(68 citation statements)

References 39 publications

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“…[156] On the other hand, PSS/PAH films deposited on human umbilical arteries showed good grafting behavior and no inflammation in a rabbit model after 12 weeks of implantation. [157] Systematic studies for each specific case are thus required.…”

Section: Pem Films Based On Synthetic Polyelectrolytesmentioning

confidence: 99%

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Boudou¹,

Crouzier²,

Ren³

et al. 2010

Advanced Materials

686

702

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The design of advanced functional materials with nanometer- and micrometer-scale control over their properties is of considerable interest for both fundamental and applied studies because of the many potential applications for these materials in the fields of biomedical materials, tissue engineering, and regenerative medicine. The layer-by-layer deposition technique introduced in the early 1990s by Decher, Moehwald, and Lvov is a versatile technique, which has attracted an increasing number of researchers in recent years due to its wide range of advantages for biomedical applications: ease of preparation under "mild" conditions compatible with physiological media, capability of incorporating bioactive molecules, extra-cellular matrix components and biopolymers in the films, tunable mechanical properties, and spatio-temporal control over film organization. The last few years have seen a significant increase in reports exploring the possibilities offered by diffusing molecules into films to control their internal structures or design "reservoirs," as well as control their mechanical properties. Such properties, associated with the chemical properties of films, are particularly important for designing biomedical devices that contain bioactive molecules. In this review, we highlight recent work on designing and controlling film properties at the nanometer and micrometer scales with a view to developing new biomaterial coatings, tissue engineered constructs that could mimic in vivo cellular microenvironments, and stem cell "niches."

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Section: Pem Films Based On Synthetic Polyelectrolytesmentioning

confidence: 99%

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Boudou¹,

Crouzier²,

Ren³

et al. 2010

Advanced Materials

686

702

View full text Add to dashboard Cite

show abstract

“…Various ways have been explored for the development of 3-D scaffolds that will interact with cells. Biological scaffolds include collagen, alginate, hyaluronic acid, and polyelectrolyte films [8,9,13]. These scaffolds could allow better regulation of cell adhesion and matrix production by resident cells.…”

Section: Scaffoldsmentioning

confidence: 99%

“…However, few investigations have considered the organization of a tissue as a basis for the development of stratified tissues (e.g., cartilage, blood vessels). From this viewpoint, complex 3-D structures of a biotissue could a priori be built layer by layer using different components [9,12]. However, up to now, few methods that can efficiently synthesize stratified structures, including viable specific cells interacting with a biofunctionalized environment have been proposed.…”

Section: Scaffoldsmentioning

confidence: 99%

Tissue Engineering: From Bench to Bed Side Exemples of Applications

Stoltz¹,

Huselstein²,

Bensoussan³

et al. 2012

ENG

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Tissue engineering is an emerging multidisciplinary field involving surgery medicine, biology, chemistry, mechanics and engineering to improve the health and quality of life by restoring, maintaining or enhancing tissue and organ functions [6;11]. The principle is simple: cells are collected and introduced -with or without modification of their biological properties-into an environment in which physico-chemical and mechanical parameters are kept stable. When they reach maturity, the biotissue or cells can be grafted. The main parameters are: cells, scaffold, biological molecules and mechanical forces. A combination of these parameters can promote cellular differentiation and proliferation. But it should be emphasized that at this time, signalling pathways and the rationale behind the physiological design remain to be elucidated. Among the main medium-term clinical applications are cardiac insufficiency, atherosclerosis, osteoarthritis, diabetes, liver diseases, bladder, and skin. In this paper the examples of cartilage and vascular engineering will be examined.

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“…Since all these studies revealed promising properties in cell culture, PAH/PSS coatings were recently evaluated in vivo. In a rabbit model, human umbilical arteries treated with PAH/PSS multilayers showed high potency for endothelial cell engraftment and no signs of inflammation during three months of implantation, holding great promises for small vessel replacement [34].…”

Section: Introductionmentioning

confidence: 99%

pH-controlled recovery of placenta-derived mesenchymal stem cell sheets

et al. 2011

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Widely used in different biomedical applications, polyelectrolyte multilayers provide inter alia an attractive way for manufacturing of bio-functionalized, stimuli responsive surface coatings to control cellular behavior. In this study a novel polyelectrolyte-based platform for the engineering and controllable detachment of human mesenchymal stem cell (MSC) sheets is presented. Thin films obtained by layerby-layer deposition of cationic poly(allylamine hydrochloride) (PAH) and anionic poly(styrene sulfonate) (PSS) polyelectrolytes on conductive indium tin oxide (ITO) electrodes allowed for the fast formation of viable sheets from human placenta-derived mesenchymal stem cells (PD-MSCs). Resulting stem cell sheets retained their phenotypical profile and mesodermal differentiation potency. Both electrochemicallyinduced local pH lowering and global decrease of the environmental pH allowed for a rapid detachment of intact stem cell sheets. The recovered stem cell sheets remained viable and maintained their capacity to differentiate toward the adipogenic and osteogenic lineages. This novel polyelectrolyte multilayer based platform represents a promising, novel approach for the engineering of human stem cell sheets desired for future clinical applications.

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Small Vessel Replacement by Human Umbilical Arteries With Polyelectrolyte Film-Treated Arteries

Abstract: The in vivo evaluation of human umbilical arteries treated with PSS/PAH multilayers demonstrated a high graft patency after 3 months of implantation. Such modified arteries could constitute a useful option for small vascular replacement.

Cited by 58 publications

References 39 publications

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Tissue Engineering: From Bench to Bed Side Exemples of Applications

pH-controlled recovery of placenta-derived mesenchymal stem cell sheets

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