Small Versus Large Particles of Demineralized Freeze‐Dried Bone Allografts in Human Intrabony Periodontal Defects

Abstract

Various particle sizes of demineralized freeze-dried bone allograft (DFDBA) are currently used to treat patients with periodontal osseous defects. However, the effect of particle size on the healing of human intrabony periodontal defects is unknown since there have been no direct clinical comparisons. The purpose of this study was to compare the bony defect resolution obtained using two different particle size ranges of DFDBA. Cortical bone from a single donor was processed and ground to final particle sizes of 250 mu to 500 mu or 850 mu to 1,000 mu using an analytic mill. Paired interproximal intrabony periodontal defects in 11 patients were grafted with DFDBA. Soft and hard tissue measurements were made using an electronic constant-force probe at the initial and reentry surgeries. Treated sites in 10 patients were reevaluated by reentry approximately 6 months postoperatively. Mean bony defect fill was 1.66 mm for the large particle group and 1.32 mm for the small particle group. There was no statistically significant difference in bony fill between defects grafted with the different particle sizes of DFDBA when used in humans.

Effect of β tricalcium phosphate particle size on recombinant human platelet-derived growth factor-BB-induced regeneration of periodontal tissue in dog

“…With porous graft materials, pore size, pore volume and porosity are important determinants of bone formation 28,29) . The spaces created between the β-TCP particles here seem to have promoted angiogenesis and favored osteoconduction.…”

A Clinical Comparison of Cerabone (A Decalcified Freeze-dried Bone Allograft) with Autogenous Bone Graft in the Treatment of Two- and Three-wall Intrabony Periodontal Defects: A Human Study with Six-month Reentry

“…20 However, one study stated that there is no significant differences in bony defect fills for two particle sizes tested (250-500 μm & 850-1000 μm). 21 Despite this, the particle size reported to have the best response is 250-750 μm similar to the range used in this study. 22 …”

Comparison of nanocrystalline hydroxyapatite and synthetic resorbable hydroxyapatite graft in the treatment of intrabony defects: A clinical and radiographic study

“…[32] found that there was no difference in defect fill between demineralized freeze dried bone allograft particles of 250-500 μm size compared to those of 850-1000 μm. In vitro analysis of the interparticulate space among bone replacement grafts condensed under a uniform standard force showed that autogenous bone harvested low and high speed rotary instruments, freeze dried bone allograft (250-710 μm).…”