Effect of β tricalcium phosphate particle size on recombinant human platelet-derived growth factor-BB-induced regeneration of periodontal tissue in dog

Irokawa, Daisuke; Ota, Mikio; Yamamoto, Shigeki; Shibukawa, Yoshihiro; Yamada, Satoru

doi:10.4012/dmj.2010-033

Cited by 14 publications

(9 citation statements)

References 29 publications

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“…Many osteoclasts were observed in the furcation defect of the tunnel group when compared with the granular group. This result was in agreement with the findings of a previous report which suggested that the number of osteoclasts on the surface of β-TCP would depend on the 3D conformation of the space structures [14]. Increase in the number of osteoclasts induced by the tunnel structure might promote the resorption of residual β-TCP in the future.…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, bone implantation in conjunction with guided tissue regeneration (GTR) membranes inhibited proliferation of epithelial tissues into furcation defects and increased periodontal regeneration [6][7][8][9][10][11][12][13]. This method, when combined with growth factors such as platelet-derived growth factor (PDGF), bone morphogenetic protein (BMP) and basic fibroblast growth factor (b FGF), accelerated bone formation and promoted periodontal regeneration [14][15][16][17][18][19]. However, it is still difficult to clinically achieve sufficient regeneration in class III furcation defects [20,21].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Tunnel Structure of β-TCP on Periodontal Repair in Class III Furcation Defects in Dogs

Saito¹,

Saito²,

Ueda³

et al. 2014

Bioceram Dev Appl

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Background: The pore characteristics of bone graft materials play an important role in bone regeneration. Previous studies have reported that a pore size of 100 ~ 400 µm effectively induces vascular invasion and cell population within the materials. Many graft materials used recently have macropore (200 ~ 600 µm) or micropore (0.1 ~ 1 µm) structures. We devised a bone material with a tunnel pipe structure and pore size of 300 µm. The present study evaluated periodontal healing following implantation of this new bone graft material in furcation class III defects. Methods: Thirty mandibular premolar teeth of five beagles were used. After class III furcation defects were surgically created, each furcation was randomly treated with: 1) β-TCP with a tunnel pipe structure (tunnel group) (n=10); 2) Granular β-TCP (granular group) (n=10); and 3) No implant material (control group) (n=10). The dogs were sacrificed 8 weeks post-surgery and healing was evaluated histologically. Results: In the tunnel group, down growth of junctional epithelium was significantly less than that in the other two groups (P <0.01) and bone formation and blood capillary invasion were observed in the inner part of pores of the implanted material in the furcation. However, little bone formation was observed between the granules in the granular group. Conclusion: β-TCP with a tunnel pipe structure and pore size of 300 µm promotes bone regeneration and new cementum formation in class III furcation defects.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Effect of Tunnel Structure of β-TCP on Periodontal Repair in Class III Furcation Defects in Dogs

Saito¹,

Saito²,

Ueda³

et al. 2014

Bioceram Dev Appl

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“…The list of osteogenic factors that have been delivered by CPS for orthopaedic and dental applications is growing and includes bone morphogenetic proteins (e.g. BMP-2, BMP-7) 67–69 , human growth hormone (hGF) 70 , platelet derived growth factor (PDGF-BB) 71, 72 , transforming growth factor beta-3 (TGF-β3) 73 , fibroblast growth factor-2 (FGF-2) 74 , platelet rich plasma (PRP) 75 and vascular endothelial growth factor (VEGF) 69, 76 . While many CPS-growth factor combinations have been tested in animals, we are only aware of one commercially available CPS-growth factor product used clinically: GEM21S® (Osteohealth) which delivers PDGF-BB in a controlled manner through the use of a β-TCP delivery vehicle for dental applications.…”

Section: Introductionmentioning

confidence: 99%

Design and characterization of calcium phosphate ceramic scaffolds for bone tissue engineering

2016

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Objectives Our goal is to review design strategies for the fabrication of calcium phosphate ceramic scaffolds (CPS), in light of their transient role in bone tissue engineering and associated requirements for effective bone regeneration. Methods We examine the various design options available to meet mechanical and biological requirements of CPS and later focus on the importance of proper characterization of CPS in terms of architecture, mechanical properties and time-sensitive properties such as biodegradability. Finally, relationships between in vitro vs. in vivo testing are addressed, with an attempt to highlight reliable performance predictors. Results A combinatory design strategy should be used with CPS taking into consideration 3D architecture, adequate surface chemistry and topography, all of which are needed to promote bone formation. CPS represent the media of choice for delivery of osteogenic factors and anti-infectives. Non-osteoblast mediated mineral deposition can confound in vitro osteogenesis testing of CPS and therefore the expression of a variety of proteins or genes including collagen type I, bone sialoprotein and osteocalcin should be confirmed in addition to increased mineral content. Conclusions CPS are a superior scaffold material for bone regeneration because they actively promote osteogenesis. Biodegradability of CPS via calcium and phosphate release represents a unique asset. Structural control of CPS at the macro, micro and nanoscale and their combination with cells and polymeric materials is likely to lead to significant developments in bone tissue engineering.

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“…Many researchers have shown that the implantation of biomaterials promotes periodontal regeneration in clinical and animal model studies [1][2][3][4][5] . Biomaterial characteristics, such as porosity, density, and crystallinity, affect the outcome of periodontal regeneration [6][7][8][9][10][11] . Several studies have reported that porous structures enhance bone formation in bone defects [12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

Periodontal repair following implantation of beta-tricalcium phosphate with different pore structures in class III furcation defects in dogs

Saito

Kuboki

et al. 2012

Dent. Mater. J.

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The aim of this study was to investigate the effect of the pore characteristics of β-tricalcium phosphate (β-TCP) on periodontal healing in class III furcation defects in dogs. Two types of β-TCP were prepared for grafting; 1) a tunnel pipe structure with an inner diameter of 300 μm, and 2) continuous pore structure with interconnected macropores. The furcations of thirty mandibular premolar teeth were implanted with each type of β-TCP or were left untreated as control. The dogs were sacrifi ced 8 weeks post-surgery, and healing was evaluated histologically. Downgrowth of junctional epithelium in the tunnel structure group was signifi cantly less than that in the other two groups (p<0.01). There was signifi cantly more new bone formation and new cementum formation in the tunnel structure group than that in the other two groups (p<0.01). These fi ndings suggested that β-TCP with a tunnel pipe structure promotes periodontal healing in class III furcation defects.

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Effect of β tricalcium phosphate particle size on recombinant human platelet-derived growth factor-BB-induced regeneration of periodontal tissue in dog

Cited by 14 publications

References 29 publications

Effect of Tunnel Structure of β-TCP on Periodontal Repair in Class III Furcation Defects in Dogs

Effect of Tunnel Structure of β-TCP on Periodontal Repair in Class III Furcation Defects in Dogs

Design and characterization of calcium phosphate ceramic scaffolds for bone tissue engineering

Periodontal repair following implantation of beta-tricalcium phosphate with different pore structures in class III furcation defects in dogs

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