Small preulcerative invasive carcinoma of the cervix: The spray carcinoma

Schiller, Walter; Daro, August F.; Gollin, Harvey A.; Primiano, Nicholas P.

doi:10.1016/0002-9378(53)90640-1

Cited by 33 publications

(2 citation statements)

References 5 publications

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“…Similarly, the age at diagnosis of HPV 16‐ and 18‐related cervical cancers is 5 years earlier than that for cancers caused by carcinogenic genotypes other than HPV 16 or 18 22 . On the other hand, at least some cervical carcinomas thought initially on clinical grounds to be rapidly progressive appear to be cervical carcinomas arising from difficult‐to‐sample areas of the cervix 23 or from non‐diagnostic precursor lesions, 24 with cytological sampling more likely to yield only rare easily overlooked abnormal cells or non‐diagnostic lesional cells 25,26 . HPV 18 infections, for example, have been linked to non‐diagnostic cytological changes that understate the severity of underlying disease during the development of cervical carcinomas otherwise thought to have arisen suddenly 27 …”

Section: Rapidly Progressive Cervical Carcinomasmentioning

confidence: 99%

Type 1 and type 2 cervical carcinomas: some cervical cancers are more difficult to prevent with screening

Austin

Zhao

2012

Cytopathology

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Although the Papanicolaou (Pap) smear is medical history's most successful cancer screening test, some cervical cancers are more difficult to prevent with screening than others. Cervical cancers that are difficult to prevent are seen disproportionately among interval cancers arising in previously screened women and in Pap test litigation. These include (i) rapidly progressing cervical cancers; (ii) cervical cancers in younger women; (iii) glandular cervical cancers; and (iv) cervical cancers in elderly women. Screening protocols have generally been designed to optimize prevention of slower-growing cervical squamous carcinomas in middle-aged women. To focus further attention on the heterogeneous screening challenges posed by different cervical cancers, we designate the more screening preventable majority as type 1 cervical cancers and the more difficult to prevent minority as type 2 cervical cancers. We review available data on why some cervical cancers are more difficult to prevent with screening and newer methods that may improve prevention.

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Section: Rapidly Progressive Cervical Carcinomasmentioning

confidence: 99%

Type 1 and type 2 cervical carcinomas: some cervical cancers are more difficult to prevent with screening

Austin

Zhao

2012

Cytopathology

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“…It is remarkable that one of the earliest reports on microinvasive cervix carcinoma (70) strongly supported cancer cell locomotion. The carcinoma cells were assumed to have emigrated from the intra-epithelial tumor like a spray (70). But this interpretation is rarely found in later publications, particularly in the extensive surveys of the sixties and seventies (71,72,73,74,75,76).…”

Section: Cancer Cell Motility During Invasion: Static Morphologymentioning

confidence: 99%