Small PLGA nanocapsules Co-encapsulating copper sulfide nanodots and fluorocarbon compound for photoacoustic imaging-guided HIFU synergistic therapy

Yao, Meicun; Ma, Ming; Xu, Hui‐Xiong; Pan, Xin; Xu, Gelin; Wu, Rong

doi:10.1039/c7ra12074e

Cited by 11 publications

(8 citation statements)

References 40 publications

(51 reference statements)

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“…At present, various materials, such as liposomes, PLGA, organic mesoporous, organic polymer, etc. have been reported for encapsulating liquid fluorocarbons [20][21][22][23][24]. At the same time, these carriers can be loaded with anticancer drugs to enable ARN to have chemotherapeutic functions and to show the ability of acoustic-controlled drug release [16,19].…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Nanoparticles with Low-Intensity Focused Ultrasound-Induced Phase Transformation as Tumor-Targeted and pH-Sensitive Theranostic Nanoplatform of Ovarian Cancer

et al. 2020

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We have developed a simple and versatile nanoplatform using pH-sensitive ferritin nanocages co-loaded with the anticancer drug curcumin (Cur) and liquid fluorocarbon perfluorohexane (PFH) inside the core and conjugated tumor-targeting molecule FA outside the shell referred to as FA-FCP. The synthesized FA-FCP has an average particle diameter of 47 nm, with stable and favorable physicochemical properties in different media, and high biocompatibility and biosafety in vivo and in vitro. Under the conditions of low-intensity focused ultrasound (LIFU) and at pH = 5.0, FA-FCP released a large amount of drugs (53.2%) in 24 h. After 4 min of LIFU (7 W) treatment, FA-FCP provided contrast-enhanced ultrasound imaging capabilities at pH = 5.0. Due to FA receptor-mediated endocytosis, FA-FCP could efficiently enter the cells and further relocate to lysosomes. Eighteen hours after injection of FA-FCP, the tumor was stimulated by LIFU, resulting in a contrast-enhanced ultrasound image. In vivo and in vitro experiments showed that the combined use of FA-FCP and LIFU had significant tumor treatment effects. Based on the results, it was concluded that FA-FCP combined with the external LIFU and the endogenic acidic environment can have powerful theranostic functions and provide a novel type of non-invasive and integrated tumor theranostic option.

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Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Nanoparticles with Low-Intensity Focused Ultrasound-Induced Phase Transformation as Tumor-Targeted and pH-Sensitive Theranostic Nanoplatform of Ovarian Cancer

et al. 2020

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“…With a particle size of 123.7 nm, CPPNs show its potential as a theranostic agent for future photoacoustic image-guided HIFU synergistic therapy of breast cancer. 95 However, high level of ultrasound energy (usually more than 100 W/cm 2 ) may cause damages to healthy tissues, especially along the path of ultrasound propagation, hence leading to severe side effects. 96 Aggregation-induced emission (AIE) is a concept originated from the phenomena that a class of fluorogens are non-emissive as free molecules but luminescent as aggregates.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

“…95 A multifunctional poly(lacticco-glycolic acid) (PLGA) nanocapsule, termed Cu 2−x S/ PFBO@PLGA or in short CPPNs, encapsulating PAI contrast copper sulfide nanodots (Cu 2−x S NDs) and a typical HIFU synergistic liquid, perfluorooctyl bromide (PFOB), has been constructed using emulsion solvent evaporation strategy. 95 The high performance of Cu 2−x S NDs in the absorption and conversion of NIR confers high PAI contrast capability to the CPPNs, by which the location of the CPPNs within a tumor can be monitored successfully under PAI. Shifting absorption from the first to the second NIR-window could enhance PAI contrast in the imaging of deep-lying living structures in vivo.…”

Section: Cancermentioning

confidence: 99%

“…HIFU concentrates multiple intersecting ultrasound beams into the targeted tumor region. Subsequently, it generates hyperthermia and mechanical effects to destroy the affected areas . A multifunctional poly(lactic- co -glycolic acid) (PLGA) nanocapsule, termed Cu 2– x S/PFBO@PLGA or in short CPPNs, encapsulating PAI contrast copper sulfide nanodots (Cu 2– x S NDs) and a typical HIFU synergistic liquid, perfluorooctyl bromide (PFOB), has been constructed using emulsion solvent evaporation strategy .…”

Section: Cancermentioning

confidence: 99%

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Nanomaterials for Nanotheranostics: Tuning Their Properties According to Disease Needs

et al. 2020

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Nanotheranostics is one of the biggest scientific breakthroughs in nanomedicine. Most of the currently available diagnosis and therapies are invasive, time-consuming and associated with severe toxic side effects. Nanotheranostics, on the other hand, has the potential to bridge this gap by harnessing the capabilities of nanotechnology and nanomaterials for combined therapeutics and diagnostics with markedly enhanced efficacy. However, nanomaterial applications in nanotheranostics are still in its infancy. This is due to the fact that each disease has a particular microenvironment with well-defined characteristics, which promotes deeper selection criteria of nanomaterials to meet the disease needs. In this review, we have outlined how nanomaterials are designed and tailored for nanotheranostics of cancer, and other diseases such as neurodegenerative, autoimmune (particularly on rheumatoid arthritis) and cardiovascular diseases. The penetrability and retention of a nanomaterial in the biological system, the therapeutic strategy used and the imaging mode selected are some of the aspects discussed for each disease. The specific properties of the nanomaterials in terms of feasibility, physicochemical challenges, progress in clinical trials, its toxicity and their future application on translational medicine are addressed. Our review meticulously and critically examines the applications of nanotheranostics with various nanomaterials, including graphene, across several diseases; offering a broader perspective of this emerging field.

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“…However, 19 F MRI techniques are limited by the lack of clinical devices because most scanners are designed for 1 H-MRI 155. Several other nanoparticles were also added to the fluorocarbon emulsions, including copper sulfide or gold nanorods as contrast agents for photoacoustic imaging 156,157, and bismuth sulfide as contrast agents for computed tomography and sensitizers for radiotherapy 18,158.…”

Section: Acoustically Active Materials For Fus Theranosticsmentioning

confidence: 99%

Colloids, nanoparticles, and materials for imaging, delivery, ablation, and theranostics by focused ultrasound (FUS)

2019

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This review focuses on different materials and contrast agents that sensitize imaging and therapy with Focused Ultrasound (FUS). At high intensities, FUS is capable of selectively ablating tissue with focus on the millimeter scale, presenting an alternative to surgical intervention or management of malignant growth. At low intensities, FUS can be also used for other medical applications such as local delivery of drugs and blood brain barrier opening (BBBO). Contrast agents offer an opportunity to increase selective acoustic absorption or facilitate destructive cavitation processes by converting incident acoustic energy into thermal and mechanical energy. First, we review the history of FUS and its effects on living tissue. Next, we present different colloidal or nanoparticulate approaches to sensitizing FUS, for example using microbubbles, phase-shift emulsions, hollow-shelled nanoparticles, or hydrophobic silica surfaces. Exploring the science behind these interactions, we also discuss ways to make stimulus-responsive, or “turn-on” contrast agents for improved selectivity. Finally, we discuss acoustically-active hydrogels and membranes. This review will be of interest to those working in materials who wish to explore new applications in acoustics and those in acoustics who are seeking new agents to improve the efficacy of their approaches.

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Small PLGA nanocapsules Co-encapsulating copper sulfide nanodots and fluorocarbon compound for photoacoustic imaging-guided HIFU synergistic therapy

Abstract: A nanometer-sized inor-ganic/organic hybrid enhancement agent is constructed for photoacoustic imaging-guided high intensity focused ultrasound therapy.

Cited by 11 publications

References 40 publications

Curcumin-Loaded Nanoparticles with Low-Intensity Focused Ultrasound-Induced Phase Transformation as Tumor-Targeted and pH-Sensitive Theranostic Nanoplatform of Ovarian Cancer

Curcumin-Loaded Nanoparticles with Low-Intensity Focused Ultrasound-Induced Phase Transformation as Tumor-Targeted and pH-Sensitive Theranostic Nanoplatform of Ovarian Cancer

Nanomaterials for Nanotheranostics: Tuning Their Properties According to Disease Needs

Colloids, nanoparticles, and materials for imaging, delivery, ablation, and theranostics by focused ultrasound (FUS)

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