Small‐Molecule Therapeutics for Ebola Virus (EBOV) Disease Treatment

Izawa, Kunisuke; Aceña, José Luis; Wang, Jiang; Soloshonok, Vadim A.; Liu, Hong

doi:10.1002/ejoc.201501158

Cited by 36 publications

(17 citation statements)

References 53 publications

(22 reference statements)

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“…Cytosine, thymine and uracil nucleobases are pyrimidine derivatives. Important pharmacophores based on the pyrimidine scaffold include drugs such as the anti‐HIV compound zidovudine, the antimalarials pyrimethamine and trimethoprim, anti‐ebola agents cidofovir and brincidofovir, and the antihypertensive minoxidil . The luminescence properties of pyrimidine derivatives began to be studied in the early 2000′s and the number of articles related to this subject has increased every year since.…”

Section: Introductionmentioning

confidence: 99%

Photoluminescence Properties of Aryl‐, Arylvinyl‐, and Arylethynylpyrimidine Derivatives

2018

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The extraordinary richness of push-pull molecules that incorporate pyrimidine rings as electron-withdrawing moieties in their structure is illustrated in this review. Interest in these pextended systems has increased dramatically over the last two decades due to their fluorescence properties and potential applications in sensing and as luminescent materials. As many as 422 different molecules are presented in an effort to establish structure-property relationships, which are often difficult to elucidate.[a] Dr.

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Section: Introductionmentioning

confidence: 99%

Photoluminescence Properties of Aryl‐, Arylvinyl‐, and Arylethynylpyrimidine Derivatives

2018

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“…This section summarizes the identification of numerous compounds with a promising anti-Ebola activity. The reader could find more detailed information related to EBOV small molecule inhibitors in the review articles of Shurtleff et al [11] and others [52][53][54][55][56][57].…”

Section: Recent Status Of Ebov Drugsmentioning

confidence: 99%

Strategies for the Development of Small Molecule Inhibitors of Ebola Viral Infection

Pleško¹,

Podlipnik²

2016

Ebola

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The recent outbreak of Ebola viral disease (EVD) in West Africa reminded us that an effective anti-viral treatment still does not exist, despite the significant progress that has recently been made in understanding biology and pathology of this lethal disease. Currently, there are no approved vaccine and/or prophylactic medication for the treatment of EVD in the market. However, the serious pandemic potential of EVD mobilized research teams in the academy and the pharmaceutical industry in the effort to find an Ebola cure as fast as possible. In this chapter, we are giving the condensed review of different approaches and strategies in search of a drug against Ebola. We have been focusing on the review of the targets that could be used for in silico, in vitro, and/or in vivo drug design of compounds that interact with the targets in different phases of the Ebola virus life cycle.

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“…In this regard, it is interesting to note the success of this strategy in the development of small-molecule therapeutics for Ebola virus (EBOV) disease treatment. 35…”

Section: Introductionmentioning

confidence: 99%

Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs

et al. 2018

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New methods for preparation of tailor-made fluorine-containing compounds are in extremely high demand in nearly every sector of chemical industry. The asymmetric construction of quaternary C−F stereogenic centers is the most synthetically challenging and, consequently, the least developed area of research. As a reflection of this apparent methodological deficit, pharmaceutical drugs featuring C−F stereogenic centers constitute less than 1% of all fluorine-containing medicines currently on the market or in clinical development. Here we provide a comprehensive review of current research activity in this area, including such general directions as asymmetric electrophilic fluorination via organocatalytic and transition-metal catalyzed reactions, asymmetric elaboration of fluorine-containing substrates via alkylations, Mannich, Michael, and aldol additions, cross-coupling reactions, and biocatalytic approaches. CONTENTS

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Small‐Molecule Therapeutics for Ebola Virus (EBOV) Disease Treatment

Cited by 36 publications

References 53 publications

Photoluminescence Properties of Aryl‐, Arylvinyl‐, and Arylethynylpyrimidine Derivatives

Photoluminescence Properties of Aryl‐, Arylvinyl‐, and Arylethynylpyrimidine Derivatives

Strategies for the Development of Small Molecule Inhibitors of Ebola Viral Infection

Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs

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