Small Molecule Probes for <sup>19</sup>F Magnetic Resonance Imaging

Li, Ao; Luo, Xiangjie; Chen, Dongxia; Li, Lingxuan; Lin, Hongyu; Gao, Jinhao

doi:10.1021/acs.analchem.2c04539

Cited by 15 publications

(14 citation statements)

References 118 publications

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“…29 Under such conditions, highperformance MOF membranes can directionally deposit on the electrode surface. 30,31 Thus, if innovating in situ directional self-assembly of MOF and Ir(III)-polyimine complex encapsulation into one-step operation, such a prepared electrode not only overcame defects of instability and poor repeatability but also exhibited higher performance and more functionality.…”

Section: ■ Introductionmentioning

confidence: 99%

Directionally In Situ Self-Assembled Iridium(III)-Polyimine Complex-Encapsulated Metal–Organic Framework Two-Dimensional Nanosheet Electrode To Boost Electrochemiluminescence Sensing

Wang

et al. 2023

Anal. Chem.

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Manufacturing electrochemiluminescence (ECL) electrodes to detect analytes with high performance in the aqueous phase for water-insoluble metal complexes is a great challenge. Here, a directional self-assembling avenue for in situ fabricating iridium(III)-polyimine complex-encapsulated metal−organic framework (MOF) two-dimensional electrode Hf-MOF/Ir 2 PD/ APS/ITO is developed. The electrode displayed bright red ECL emission with high stability in the aqueous phase and specific adsorption toward ssDNA against dsDNA and mNs. That is to say, a "high-performance and multifunctional ECL electrode" is presented and explored for sensitive detection of acetamiprid (Ace) with a limit of detection of 0.0025 nM, where Ace-aptamer recognition-switched Exonuclease III-mediated digestion to make large numbers of Fc-labeled ssDNA transform into Fc-mNs. Furthermore, the proposed method was triumphantly employed to monitor the change in the residual concentration of Ace in pakchoi. This work breaks through the bottleneck of metal complexbased ECL emission in organic solvents and provides a novel strategy to develop high-performance ECL sensors.

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Section: ■ Introductionmentioning

confidence: 99%

Directionally In Situ Self-Assembled Iridium(III)-Polyimine Complex-Encapsulated Metal–Organic Framework Two-Dimensional Nanosheet Electrode To Boost Electrochemiluminescence Sensing

Wang

et al. 2023

Anal. Chem.

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“…Nevertheless, the capacity of 1 H MRI for tracing crucial biological molecules, the concentrations of which are much less than that of water molecules, is restricted by 1 H's high biological background [23] . Among other nuclei suitable for MRI, 19 F draws the attention of the research community because of its high MR sensitivity (comparable to that of 1 H), 100 % natural abundance, and negligible biological background [24–31] . Besides, the wide range of 19 F chemical shifts (>350 ppm) and the diversity of biocompatible fluorine‐containing agents permit multi‐spectral color‐coded 19 F MRI that is capable of tracing multiple targets [32–36] .…”

Section: Introductionmentioning

confidence: 99%

Glycan Metabolic Fluorine Labeling for In Vivo Visualization of Tumor Cells and In Situ Assessment of Glycosylation Variations

Chen,

Lin,

Fan

et al. 2023

Angew Chem Int Ed

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The abnormality in the glycosylation of surface proteins is critical for the growth and metastasis of tumors and their capacity for immunosuppression and drug resistance. This anomaly offers an entry point for real‐time analysis on glycosylation fluctuations. In this study, we report a strategy, glycan metabolic fluorine labeling (MEFLA), for selectively tagging glycans of tumor cells. As a proof of concept, we synthesized two fluorinated unnatural monosaccharides with distinctive 19F chemical shifts (Ac4ManNTfe and Ac4GalNTfa). These two probes could undergo selective uptake by tumor cells and subsequent incorporation into surface glycans. This approach enables efficient and specific 19F labeling of tumor cells, which permits in vivo tracking of tumor cells and in situ assessment of glycosylation changes by 19F MRI. The efficiency and specificity of our probes for labeling tumor cells were verified in vitro with A549 cells. The feasibility of our method was further validated with in vivo experiments on A549 tumor‐bearing mice. Moreover, the capacity of our approach for assessing glycosylation changes of tumor cells was illustrated both in vitro and in vivo. Our studies provide a promising means for visualizing tumor cells in vivo and assessing their glycosylation variations in situ through targeted multiplexed 19F MRI.

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“…Microfluidics is now able to perform a range of functions in the fields of chemical analysis 2,3 and biological detection, [4][5][6][7][8] such as organismal body analysis, 9 drug encapsulation, 10 cell encapsulation, 11 cell screening and sequencing, 12 and nebulizer treatment, 13 etc. Among these examples, microfluidics has demonstrated the ability to manipulate individual droplets and micro to nano-objects in liquids, enabled by various forces associated with magnetics, 14 optical, 15 acoustics, 16,17 electrowetting-ondielectrics, dielectrophoresis, and hydrodynamics.…”

Section: Introductionmentioning

confidence: 99%

Acoustofluidics for simultaneous droplet transport and centrifugation facilitating ultrasensitive biomarker detection

Qian,

Lan,

Huang

et al. 2023

Lab Chip

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Small Molecule Probes for ¹⁹F Magnetic Resonance Imaging

Cited by 15 publications

References 118 publications

Directionally In Situ Self-Assembled Iridium(III)-Polyimine Complex-Encapsulated Metal–Organic Framework Two-Dimensional Nanosheet Electrode To Boost Electrochemiluminescence Sensing

Directionally In Situ Self-Assembled Iridium(III)-Polyimine Complex-Encapsulated Metal–Organic Framework Two-Dimensional Nanosheet Electrode To Boost Electrochemiluminescence Sensing

Glycan Metabolic Fluorine Labeling for In Vivo Visualization of Tumor Cells and In Situ Assessment of Glycosylation Variations

Acoustofluidics for simultaneous droplet transport and centrifugation facilitating ultrasensitive biomarker detection

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Small Molecule Probes for 19F Magnetic Resonance Imaging

Cited by 15 publications

References 118 publications

Directionally In Situ Self-Assembled Iridium(III)-Polyimine Complex-Encapsulated Metal–Organic Framework Two-Dimensional Nanosheet Electrode To Boost Electrochemiluminescence Sensing

Directionally In Situ Self-Assembled Iridium(III)-Polyimine Complex-Encapsulated Metal–Organic Framework Two-Dimensional Nanosheet Electrode To Boost Electrochemiluminescence Sensing

Glycan Metabolic Fluorine Labeling for In Vivo Visualization of Tumor Cells and In Situ Assessment of Glycosylation Variations

Acoustofluidics for simultaneous droplet transport and centrifugation facilitating ultrasensitive biomarker detection

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Small Molecule Probes for ¹⁹F Magnetic Resonance Imaging