Directionally In Situ Self-Assembled Iridium(III)-Polyimine Complex-Encapsulated Metal–Organic Framework Two-Dimensional Nanosheet Electrode To Boost Electrochemiluminescence Sensing

Abstract

Manufacturing electrochemiluminescence (ECL) electrodes to detect analytes with high performance in the aqueous phase for water-insoluble metal complexes is a great challenge. Here, a directional self-assembling avenue for in situ fabricating iridium(III)-polyimine complex-encapsulated metal−organic framework (MOF) two-dimensional electrode Hf-MOF/Ir 2 PD/ APS/ITO is developed. The electrode displayed bright red ECL emission with high stability in the aqueous phase and specific adsorption toward ssDNA against dsDNA and mNs. That is to say, a "high-performance and multifunctional ECL electrode" is presented and explored for sensitive detection of acetamiprid (Ace) with a limit of detection of 0.0025 nM, where Ace-aptamer recognition-switched Exonuclease III-mediated digestion to make large numbers of Fc-labeled ssDNA transform into Fc-mNs. Furthermore, the proposed method was triumphantly employed to monitor the change in the residual concentration of Ace in pakchoi. This work breaks through the bottleneck of metal complexbased ECL emission in organic solvents and provides a novel strategy to develop high-performance ECL sensors.

Ratiometric Electrochemiluminescence of Zirconium Metal–Organic Framework as a Single Luminophore for Sensitive Detection of HPV-16 DNA

“…The metal–organic framework (MOF) is a type of crystalline material which is composed of central metal ions or clusters and bridged organic ligands. − Due to its excellent performance of designable and tunable function, the MOF material has strong application outlooks in the electrochemical biosensor domain, particularly in terms of the MOF as the ECL luminophore. − More impressively, some dual-ligand MOF materials with better performance have been developed that combine different functional ligands to achieve dual functionalization. For instance, Zhang’s group prepared the M6-MOF with two links of 1,3,6,8-tetra (4′-carboxyphenyl) pyrene (TABPy) and 5,10,15,20-tetra­(4-carboxyphenyl)­porphyrin (TCPP), where TCPP facilitated electron transfer to enhance the ECL emission of TABPy .…”

Zirconium-based metal–organic framework loaded agarose hydrogels for fluorescence turn-on detection of nerve agent simulant vapor

“…17 Due to excellent chemical and physical properties, MOFs with diverse topological networks and fascinating structures are widely used in sensing, energy storage, drug transport, catalysis, bioimaging, etc. 18–23 Organic small molecule-based fluorescent probes have been developed for the detection of DCP , but the application of MOF-based fluorescent probes for nerve agent simulant detection has been rarely reported. 24–26…”

“…17 Due to excellent chemical and physical properties, MOFs with diverse topological networks and fascinating structures are widely used in sensing, energy storage, drug transport, catalysis, bioimaging, etc. [18][19][20][21][22][23] Organic small molecule-based uorescent probes have been developed for the detection of DCP, but the application of MOF-based uorescent probes for nerve agent simulant detection has been rarely reported. [24][25][26] MOFs can be used as probes for direct detection of hazardous substances in the liquid phase but not for tracking and warning of hazardous gases, and to overcome this problem, suitable support materials must be selected for the dispersion and immobilization of MOFs.…”

DNA Polymerase-Steered Self-Propelled and Self-Enhanced DNA Walker for Rapid and Distinctly Amplified Electrochemical Sensing

“…Sensitive and accurate bioanalysis by the simple, rapid, and easy-to-operate biosensing method is critical for the numerous applications in disease diagnosis, environmental monitoring, and biomedicine. − Till now, various biosensors based on different measurement means, such as colorimetry, fluorescence, electrochemistry, electro-chemiluminescence, photoelectrochemistry, etc., have been well developed. − Among them, the electrochemical biosensor shows some attractive features such as cost-effective instrumentation, facile operation, high sensitivity, and ease of miniaturization and integration, holding a great potential for point-of-care applications. − Even though great advances have been made in electrochemical biosensors during the past decades, the ever-increasing applicative demands for the rapid and accurate profiling of analytes with low abundance pose a challenge for current biosensing methods.…”