Small mammals as reservoir hosts for Borrelia in Russia

Горелова, Н. Б.; Éi, Korenberg; Kovalevskii, Yurii V.; Щербаков, С. В.

doi:10.1016/s0934-8840(11)80132-5

Cited by 23 publications

(17 citation statements)

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“…The different genospecies of B. burgdorferi sensu lato appear to cause distinct clinical manifestations of Lyme borreliosis in humans (28). Consistent with this, arthritis is common in North America, where B. burgdorferi sensu stricto predominates, whereas in Eurasia, neuroborreliosis and acrodermatitis are typical disease manifestations, reflecting the high abundance of Borrelia garinii and Borrelia afzelii throughout this region (5,7,16,20,25). Other genospecies, such as Borrelia lusitaniae (former genomic group PotiB2), Borrelia valaisiana (former genomic group VS116), and Borrelia japonica from Japan or Borrelia andersonii from the United States, have not yet been associated with disease in humans.…”

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confidence: 63%

Serum Complement Sensitivity as a Key Factor in Lyme Disease Ecology

et al. 1998

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The sensitivity of Borrelia burgdorferi sensu lato to animal sera was analyzed. Complement-mediated borreliacidal effects were observed with particular combinations of host serum and Borrelia genospecies. The species-specific pattern of viability and/or lysis is highly consistent with the pattern of reservoir competence of hosts for B. burgdorferi sensu lato, suggesting a key role of complement in the global ecology of Lyme borreliosis.

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confidence: 63%

Serum Complement Sensitivity as a Key Factor in Lyme Disease Ecology

et al. 1998

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“…in Europe [12, 13]. Previous studies from France, Ireland and Austria showed prevalence of B. burgdorferi ( s.l .)…”

Section: Discussionmentioning

confidence: 99%

The enzootic life-cycle of Borrelia burgdorferi (sensu lato) and tick-borne rickettsiae: an epidemiological study on wild-living small mammals and their ticks from Saxony, Germany

et al. 2017

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Background Borrelia burgdorferi (sensu lato) and rickettsiae of the spotted fever group are zoonotic tick-borne pathogens. While small mammals are confirmed reservoirs for certain Borrelia spp., little is known about the reservoirs for tick-borne rickettsiae. Between 2012 and 2014, ticks were collected from the vegetation and small mammals which were trapped in Saxony, Germany. DNA extracted from ticks and the small mammals’ skin was analyzed for the presence of Rickettsia spp. and B. burgdorferi (s.l.) by qPCR targeting the gltA and p41 genes, respectively. Partial sequencing of the rickettsial ompB gene and an MLST of B. burgdorferi (s.l.) were conducted for species determination.ResultsIn total, 673 small mammals belonging to eight species (Apodemus agrarius, n = 7; A. flavicollis, n = 214; Microtus arvalis, n = 8; Microtus agrestis, n = 1; Mustela nivalis, n = 2; Myodes glareolus, n = 435; Sorex araneus, n = 5; and Talpa europaea, n = 1) were collected and examined. In total, 916 questing ticks belonging to three species (Ixodes ricinus, n = 741; Dermacentor reticulatus, n = 174; and I. trianguliceps, n = 1) were collected. Of these, 474 ticks were further investigated. The prevalence for Rickettsia spp. and B. burgdorferi (s.l.) in the investigated small mammals was 25.3 and 31.2%, respectively. The chance of encountering Rickettsia spp. in M. glareolus was seven times higher for specimens infested with D. reticulatus than for those which were free of D. reticulatus (OR: 7.0; 95% CI: 3.3–14.7; P < 0.001). In total, 11.4% of questing I. ricinus and 70.5% of D. reticulatus were positive for Rickettsia spp. DNA of B. burgdorferi (s.l.) was detected only in I. ricinus (5.5%). Sequence analysis revealed 9 R. helvetica, 5 R. raoultii, and 1 R. felis obtained from 15 small mammal samples.ConclusionSmall mammals may serve as reservoirs for Rickettsia spp. and B. burgdorferi (s.l.). While the prevalence for Rickettsia spp. in M. glareolus is most likely depending on the abundance of attached D. reticulatus, the prevalence for B. burgdorferi (s.l.) in small mammals is independent of tick abundance. Dermacentor reticulatus may be the main vector of certain Rickettsia spp. but not for Borrelia spp.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-017-2053-4) contains supplementary material, which is available to authorized users.

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“…Different clinical manifestations are often associated with the different genospecies, as are different reservoir hosts; see Table 5, in Section 7.1 (Humair & Gern, 2000;Kurtenbach et al, 2002). However, this does not seem be the case in the Russian Federation and eastern parts of Europe where non-specific maintenance cycles involving small mammals and various borrelia species have been described (Gorelova et al, 1995;Richter et al, 1999).…”

Section: Pathogen Transmission Cyclementioning

confidence: 99%