Serum Complement Sensitivity as a Key Factor in Lyme Disease Ecology

Kurtenbach, Klaus; Sewell, Henna-Sisko; Ogden, N. H.; Randolph, Sarah; Nuttall, Patricia A.

doi:10.1128/iai.66.3.1248-1251.1998

Cited by 252 publications

(114 citation statements)

References 30 publications

(45 reference statements)

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“…Borreliacidal property of sheep serum complement against B. garinii serotypes and B. valaisiana-VS116 observed by us was in disagreement with the earlier reported >95% bacteriolysis [7]. In addition, we found a comparative resistance of B. garinii serotype 3 (Rio2) and 4 (Pbi) to sheep complement.…”

Section: Discussioncontrasting

confidence: 96%

“…In case of European bison, characteristic borrelialysis was recorded with lower intensity than in cattle. The borreliacidal property of cattle serum complement reported earlier [7] was comparable with the results observed in our study. The pronounced borreliacidal ability observed in cattle and European bison indicates their resistance against borrelial infection.…”

Section: Discussionsupporting

confidence: 92%

“…The pattern of serum complement sensitivity of different Borrelia genospecies matches the known reservoir status of many vertebrate species for B. burgdorferi sensu lato [7]. Several studies indicate that B. garinii and B. valaisiana are mainly transmitted to ticks by avian hosts, whereas, B. afzelii is transmitted to tick via rodents.…”

Section: Introductionmentioning

confidence: 62%

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Sensitivity ofBorreliagenospecies to serum complement from different animals and human: a hostâpathogen relationship

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Trávníček

Levkutová

et al. 2005

FEMS Immunology &Amp; Medical Microbiology

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Different Borrelia species and serotypes were tested for their sensitivity to serum complement from various animals and human. Complement-mediated Borrelia killing in cattle, European bison and deer was higher irrespective of the Borrelia species whereas in other animals and human it was intermediate and Borrelia species-dependent. Activation of the alternative complement pathway by particular Borrelia strain was in correlation with its sensitivity or resistance. These results support the incompetent reservoir nature of cattle, European bison, red, roe and fallow deer, at the same time present the probable reservoir nature of mouflon, dog, wolf, cat and lynx. In short, this study reviews Borrelia-host relationship and its relevance in reservoir competence nature of animals.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussionsupporting

confidence: 92%

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Sensitivity ofBorreliagenospecies to serum complement from different animals and human: a hostâpathogen relationship

Bhide

Trávníček

Levkutová

et al. 2005

FEMS Immunology &Amp; Medical Microbiology

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“…The sequence variation of these proteins suggests a host-to-host difference of complement. Consistent with the amino acid variation in different host complement proteins, different Lyme borreliae species/strains differ in their ability to survive in vertebrate host sera (Kurtenbach et al, 1998b;2002a;Ullmann et al, 2003) (Fig. 2).…”

Section: Lyme Borreliae Develop Host-specific Serum Resistance Activisupporting

confidence: 69%

Outer surface protein polymorphisms linked to host‐spirochete association in Lyme borreliae

Tufts

Hart

Chen

et al. 2019

Molecular Microbiology

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Summary Lyme borreliosis is caused by multiple species of the spirochete bacteria Borrelia burgdorferi sensu lato. The spirochetes are transmitted by ticks to vertebrate hosts including small and mediumsized mammals, birds, reptiles, and humans. Strain-to-strain variation in host specific infectivity has been documented, but the molecular basis that drives this differentiation is still unclear. Spirochetes possess the ability to evade host immune responses and colonize host tissues to establish infection in vertebrate hosts. In turn, hosts have developed distinct levels of immune responses when invaded by different species/strains of Lyme borreliae. Similarly, the ability of Lyme borreliae to colonize host tissues varies among different spirochete species/strains. One potential mechanism that drives this strain-to-strain variation of immune evasion and colonization is the polymorphic outer surface proteins produced by Lyme borreliae. In this review, we summarize research on strain-to-strain variation in host competence and discuss the evidence that supports the role of spirocheteproduced protein polymorphisms in driving this variation in host specialization. Such information will provide greater insights into the adaptive mechanisms driving host and Lyme borreliae association, which will lead to the development of interventions to block pathogen spread and eventually reduce Lyme borreliosis health burden.

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“…has emerged that is consistent with pattern of transmissibility. [23][24][25][26] The molecular mechanism of this protection has been dissected, and bacterial membrane proteins have been shown to bind to complement control proteins preventing the formation of the membrane-attack complex. The deflection of the complement system is now considered to be 1 of the key determinant of the niche of B. burgdorferi s.l.…”

Section: Is Mammalian Host Specificity Of Bartonella Due To Resistancmentioning

confidence: 99%

Insights in Bartonella Host Specificity

Vayssier‐Taussat

Rhun

Bonnet

et al. 2009

Annals of the New York Academy of Sciences

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The genus Bartonella comprises a unique group of emerging gram-negative, intracellular bacteria that can cause a long-lasting intraerythrocytic bacteremia in their reservoir hosts. In recent years, the widespread occurrence and diversity of these bacteria has been increasingly recognized. This has resulted in a dramatic expansion of the genus Bartonella to 24 currently described species or subspecies, among which at least half have been associated with human disease. Bartonella infections have been observed in virtually all species examined, extending from humans to carnivores, ungulates, rodents, lagomorphs, insectivores, and bats. Adaptation by Bartonellae to such a diverse range of mammals has resulted in host specificity, and all validated Bartonella species described to date are capable of parasitizing only a limited number of animal species. In this review, the possible mechanisms explaining the specificity of each Bartonella species for its reservoir host are discussed.

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Serum Complement Sensitivity as a Key Factor in Lyme Disease Ecology

Cited by 252 publications

References 30 publications

Sensitivity ofBorreliagenospecies to serum complement from different animals and human: a hostâpathogen relationship

Sensitivity ofBorreliagenospecies to serum complement from different animals and human: a hostâpathogen relationship

Outer surface protein polymorphisms linked to host‐spirochete association in Lyme borreliae

Insights in Bartonella Host Specificity

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Serum Complement Sensitivity as a Key Factor in Lyme Disease Ecology

Cited by 252 publications

References 30 publications

Sensitivity ofBorreliagenospecies to serum complement from different animals and human: a hostâpathogen relationship

Sensitivity ofBorreliagenospecies to serum complement from different animals and human: a hostâpathogen relationship

Outer surface protein polymorphisms linked to host‐spirochete association in Lyme borreliae

Insights in Bartonella Host Specificity

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Product

Resources

About

Sensitivity ofBorreliagenospecies to serum complement from different animals and human: a hostâpathogen relationship

Sensitivity ofBorreliagenospecies to serum complement from different animals and human: a hostâpathogen relationship