Small Intestinal Disaccharidase Activity and Ileal Villus Height Are Increased in Piglets Consuming Formula Containing Recombinant Human Insulin-Like Growth Factor-I

Houle, Vicki M.; Schroeder, Elizabeth A.; Odle, Jack; Donovan, Sharon M.

doi:10.1203/00006450-199707000-00013

Cited by 100 publications

(81 citation statements)

References 30 publications

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“…Moreover, IGF-I present in sow colostrum and milk stimulates gastrointestinal tissue growth and functional maturation in newborn piglets. IGF-I adjunction to milk formulas increases intestinal weight and villosity height (Burrin et al, 1996), brush border enzyme activities (Houle et al, 1997), and the rates of net Na 1 -and Na 1 -dependent nutrient absorption (Alexander and Carey, 1999). On the contrary, GH delivered with an osmotic minipump into the abdominal cavity of newborn piglets failed to improve the absorptive capacity of the small intestine (Fholenhag et al, 1999).…”

Section: Regulation Of Porcine Neonatal Growth and Development By Hormentioning

confidence: 99%

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Morise

Louveau

Huërou‐Luron

2008

Animal

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With genetic selection, the increase in litter size has led to higher variation in within-litter birth weights in pigs. This has been associated with a reduction in mean birth weights and a rise in the proportion of piglets weighing less than 1 kg at birth. Low birth weight pigs exhibit lower postnatal growth rates and feed efficiency, which may be explained by an inadequate digestion and/or nutrient use as a consequence of prenatal undernutrition. It is now documented that there is a relationship between birth weight and subsequent pattern of growth and development of tissues and organs. During the neonatal period, the rapid somatic growth is accompanied by tremendous anatomical, physiological and chemical composition changes. The present review focuses primarily on the influence of low birth weight on adipose tissue and the gastrointestinal tract growth and development during the suckling period. The importance of the somatotropic axis, insulin, thyroid hormones, glucocorticoids, epidermal growth factor and leptin in the regulation of these developmental processes is also considered.

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Section: Regulation Of Porcine Neonatal Growth and Development By Hormentioning

confidence: 99%

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Morise

Louveau

Huërou‐Luron

2008

Animal

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“…The animal protocol was approved by the Laboratory Animal Care Advisory Committee of the University of Illinois and was in compliance with National Research Council guidelines for the care and use of laboratory animals (10). Colostrum-deprived piglets (n ϭ 36) were obtained by cesarean section from term pregnant Yorkshire-Duroc sows and were housed as previously described (6). Two experiments were conducted.…”

Section: Methodsmentioning

confidence: 99%

“…Our group and others have shown that orally administered IGF-I stimulates intestinal villus growth (4 -6) and LPH activity (E.C. 3.2.1.23-62) (6) in the neonatal piglet.…”

mentioning

confidence: 99%

Investigation of Three Doses of Oral Insulin-like Growth Factor-I on Jejunal Lactase Phlorizin Hydrolase Activity and Gene Expression and Enterocyte Proliferation and Migration in Piglets

et al. 2000

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In a previous study, oral IGF-I at 65 nM increased lactase phlorizin hydrolase (LPH) activity and villus height in piglets, however, the mechanisms were unknown. Herein, the response to a range of doses of IGF-I was investigated and we hypothesized that LPH and villus height would respond to oral IGF-I in a dose-dependent manner. Two 14-d experiments were conducted using cesarean-derived piglets. In experiment 1, piglets (n ϭ 28) were fed formula containing 0, 33, 65, or 131 nmol/L (0, 0.25, 0.5, or 1.0 mg/L) recombinant human IGF-I. In experiment 2, 5Ј-bromodeoxyuridine was administered to piglets fed formula alone (n ϭ 4) or containing 131 nmol/L IGF-I (n ϭ 4). IGF-I did not affect body weight gain or intestinal weight or length. Jejunal villus height and LPH activity were significantly greater in piglets fed 131 nmol IGF-I/L than control piglets. Abbreviations AP-1, activator protein-1 BrdU, 5Ј-bromodeoxyuridine C/EBP, CCAAT/enhancer binding protein EF1-␣, elongation factor 1-␣ FLE, foremost labeled enterocyte HNF-1, hepatocyte nuclear factor-1 LPH, lactase phlorizin hydrolase BB LPH, brush border lactase phlorizin hydrolase proLPH h , high mannose lactase phlorizin hydrolase precursor proLPH c , complex glycosylated lactase phlorizin hydrolase precursor MAPK, mitogen activated protein kinase NHS, normal horse serum PI 3-kinase, phosphatidylinositol 3-kinaseThe presence of IGF-I in colostrum and milk (1) and IGF receptors within the intestine (2) has led to the postulate that milk-borne IGF-I could play a role in neonatal intestinal development (3). Our group and others have shown that orally administered IGF-I stimulates intestinal villus growth (4 -6) and LPH activity (E.C. 3.2.1.23-62) (6) in the neonatal piglet.However, the doses of IGF-I administered in these experiments (65-1300 nmol/L) were above the concentrations of IGF-I present in porcine colostrum (13-52 nmol/L) or mature milk (1.3-2.6 nmol/L) (7). It was unknown whether oral administration of lower doses of IGF-I would exert similar biologic effects within the neonatal intestine. Further, the mechanisms by which oral IGF-I up-regulated intestinal LPH activity and villus growth had not been described. Therefore, the goals of the current study were to determine the impact of a range of doses of oral IGF-I on intestinal villus growth and LPH activity and to investigate potential mechanisms underlying these ef-

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“…It is, however, interesting to notice that subcutaneous treatment of formula-fed rabbits with EGF significantly reduced bacteria translocation to levels similar to those in suckled rabbits (99) . IGF-I might also have a trophic effect, since feeding piglets with formula supplemented with pharmacological doses of recombinant human IGF-I increases enzymes (lactase and maltase) and villous height of the small intestine (100) compared with non-supplemented animals. Results are not so clear-cut when physiological doses of IGF-I are provided to young piglets (101) .…”

Section: Growth Factorsmentioning

confidence: 99%

Breast-v.formula-feeding: impacts on the digestive tract and immediate and long-term health effects

2010

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The health benefits of breast-feeding have been recognised for a long time. In particular, breast-feeding is associated with lower incidence of necrotising enterocolitis and diarrhoea during the early period of life and with lower incidence of inflammatory bowel diseases, type 2 diabetes and obesity later in life. The higher nutritional and protective degree of human milk is related to its nutritional composition that changes over the lactation period and to the biological activities of specific components while lower growth rate of breast-fed infants may be attributed to their self-regulation of milk intake at a lower level than formula-fed infants. Many results now suggest that the developmental changes in intestinal and pancreatic function that occur postnatally are modulated by the diet. Indeed, formula-feeding induces intestinal hypertrophy and accelerates maturation of hydrolysis capacities; it increases intestinal permeability and bacterial translocation, but does not induce evident differences in microbiota composition. Whether these changes would be beneficial for enhancing absorptive capacities and for educating the gut-associated immune system remains to be further studied. Moreover, it is evident that formula-feeding increases basal blood glucose and decreases plasma ketone body concentrations, while discrepancies on postprandial glycaemia, insulin and incretin responses in both human studies and experimental studies are inconclusive. Manipulating the composition of formula, by reducing protein content, adding prebiotics, growth factors or secretory IgA can modulate intestinal and pancreatic function development, and thereby may reduce the differential responses between breast-fed and formula-fed neonates. However, the developmental responses of the digestive tract to different feeding strategies must be elucidated in terms of sensitivity to developing diseases, taking into account the major role of the intestinal microbiota.

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Small Intestinal Disaccharidase Activity and Ileal Villus Height Are Increased in Piglets Consuming Formula Containing Recombinant Human Insulin-Like Growth Factor-I

Cited by 100 publications

References 30 publications

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Investigation of Three Doses of Oral Insulin-like Growth Factor-I on Jejunal Lactase Phlorizin Hydrolase Activity and Gene Expression and Enterocyte Proliferation and Migration in Piglets

Breast-v.formula-feeding: impacts on the digestive tract and immediate and long-term health effects

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