Small-Intestinal Absorption Before and After Vagotomy in Man

Cox, AlanG.

doi:10.1016/s0140-6736(62)90783-3

Cited by 23 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wells et al [1964] and Ross et al [1963] using specially sensitive amplification or telemetering devices showed that muscular activity of the small intestine returned in about 12 h. The absorptive capacity of the small intestine has also been shown to return to normal after vagotomy and pyloroplasty. Cox [1962] showed that the absorption of electrolytes and carbohydrates was within normal limits 18 h after this operation.…”

Section: Intraduodenal and Intrajejunal Feedingmentioning

confidence: 77%

Nutrition in the Post-Traumatic Period

et al. 1972

View full text Add to dashboard Cite

The early depression of metabolism, local and general, immediately following injury other than mild trauma – ‘the ebb phase’ – lasts some hours. It is then generally followed by a period of enhanced heat production and the early hyperglycaemía gives way to an excess of protein catabolism over anabolism which is more general than local – ‘the flow phase’. These are at their height 5–8 days after injury and the excess urinary nitrogen excretion is paralleled by increases in urinary sulphur, phosphorus, potassium, magnesium, zinc and creatine. Hospitalisation in a warm (28–30 °C) and relatively dry environment will reduce this excessive catabolism. Where there is inability to ingest, digest or absorb sufficient food over a period of several days and the patient’s condition is likely to deteriorate, then recourse must be made to intraduodenal or jejunal feeding or to parenteral feeding. The amino acid requirements for replacement of haemoglobin if it has not been done through appropriate transfusion can be particularly demanding in respect of certain amino acids. Obviously the non-amino acid sources of energy, as well as the other nutrients, should be suitable for the optimal utilisation of the infused amino acids.

show abstract

Section: Intraduodenal and Intrajejunal Feedingmentioning

confidence: 77%

Nutrition in the Post-Traumatic Period

et al. 1972

View full text Add to dashboard Cite

show abstract

“…Carbohydrate There is no evidence of any impairment of either carbohydrate digestion or absorption after these operations. When studying the feasibility of duodenal feeding after vagotomy Cox (1962) demonstrated slight delay in glucose absorption 18 hr after operation which had returned to normal 6 days later. Williams & Irvine (1966) found a 'flat lactose curve' in 9% of patients after total and 12% of patients after selective vagotomy and pyloroplasty but, as they point out, their findings are probably not significantly different from a control population.…”

Section: Protein Absorptionmentioning

confidence: 99%

Metabolic effects of vagotomy and gastric drainage

Wastell

1967

Postgraduate Medical Journal

View full text Add to dashboard Cite

“…In a clinical study Cox (1962) introduced radioactive sodium iodine (Na1311) into the intestine and measured the equilibration of the absorbed radioactive iodine in the peripheral blood. His studies were performed before operation, 18 hours after operation, and one week after operation.…”

Section: Discussionmentioning

confidence: 99%

The effects of vagotomy on the intestinal handling of water and electrolytes

Bunch¹,

Shields²

1973

Gut

View full text Add to dashboard Cite

SUMMARY A technique of intestinal perfusion has been used to investigate the effects of vagotomy on the intestinal handling of water and electrolytes. The capacity of the vagotomized jejunum to absorb water and electrolytes was found to be unimpaired, even in patients who had severe postvagotomy diarrhoea.Diarrhoea is well recognized as a cause of morbidity after the operation of vagotomy and gastric drainage for duodenal ulceration. Diarrhoea may be said to represent the malabsorption ofwater and electrolytes, and in spite of a great deal of investigation the cause ofthis diarrhoea remains unexplained. The possibility that a defect in the ability of the intestine to absorb water and electrolytes may explain this diarrhoea has been investigated, and in this paper we report on the intestinal handling of water and the principal electrolytes-sodium and potassium-immediately after operation when the effects of vagotomy might be expected to be maximal and later, in patients with and without severe postvagotomy diarrhoea. Patients StudiedSuccessful studies were performed upon 25 subjects; nine of these were patients undergoing truncal vagotomy and nine were patients undergoing cholecystectomy. Of these 18 patients, all except one of them were studied twice immediately after operation, first at six hours and again between 24 and 30 hours after operation.Of the nine patients undergoing vagotomy, three were studied on the day before operation and four of the patients undergoing cholecystectomy were also studied on the day before operation. Additional control data were obtained from four healthy volunteer subjects not undergoing surgery; one of these was studied on two occasions, giving a total of 12 control, or contrast studies. These contrast studies are assumed to represent normal absorption before operation.'Please address requests for reprints to Mr G. A. Bunch, The Royal Infirmary, Ifuddersfield.Received for publication 6 December 1972. After the 10th postoperative day, three patients who had had a vagotomy were studied and three patients with severe postvagotomy diarrhoea who passed frequent, watery stools daily were also studied. Technique of StudyPatients were studied using a technique of intestinal perfusion similar to that described by Phillips and Summerskill (1966). The principle of the method is that a segment of small intestine is perfused with a test solution of known composition. At the end of the test segment the perfusate is sampled by aspiration and analysed. From the change occurring in the volume and composition of the test solution during its passage through the test segment, the rate of absorption from the segment can be calculated.A double-lumen tube, suitably modified (Fig.), was passed through the nose until it reached the upper jejunum. The position of the tube was ascertained by radiographic screening. The proximal balloon (C in the figure) was sited just beyond the duodeno-jejunal flexure.The test solution was modified Tyrode's solution containing Na+-149 m-equiv/1, K+-3.3 m-equiv/1, Cl--1...

show abstract

Small-Intestinal Absorption Before and After Vagotomy in Man

Cited by 23 publications

References 4 publications

Nutrition in the Post-Traumatic Period

Nutrition in the Post-Traumatic Period

Metabolic effects of vagotomy and gastric drainage

The effects of vagotomy on the intestinal handling of water and electrolytes

Contact Info

Product

Resources

About