Small correlation between salivary α‐amylase activity and pain intensity in patients with cancer pain

Arai, Y.-C. P.; Matsubara, Tatsuhiro; Shimo, Kazuhiro; Osuga, T.; Ushida, Takahiro; Suzuki, Chihiro; Ohta, Aya; Tohyama, Yukio; Nishida, Kikuyo; Arakawa, Maki

doi:10.1111/j.1399-6576.2008.01833.x

Cited by 14 publications

(23 citation statements)

References 5 publications

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“…Similar observations were made by Arai et al. [15], who reported a possible influence of anxiety commonly found in cancer patients on the salivary concentrations of alpha‐amylase.…”

Section: Discussionsupporting

confidence: 87%

Salivary Alpha-Amylase Activity: A Possible Indicator of Pain-Induced Stress in Orthodontic Patients

Campos¹,

Raposo²,

Ferreira

et al. 2011

Pain Med

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“…Similar observations were made by Arai et al. [15], who reported a possible influence of anxiety commonly found in cancer patients on the salivary concentrations of alpha‐amylase.…”

Section: Discussionsupporting

confidence: 87%

Salivary Alpha-Amylase Activity: A Possible Indicator of Pain-Induced Stress in Orthodontic Patients

Campos¹,

Raposo²,

Ferreira

et al. 2011

Pain Med

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“…Our main aim was to evaluate the influence of pain on gastric fundal accommodation and gastric motility. It has previously been reported that pain reduces autonomic nervous system activity [ 9 , 10 ]; however, there have been no objective reports illuminating the relationship between pain and gastric fundal accommodation and gastric motility. Our findings suggest that even tolerable pain can affect gastrointestinal function.…”

Section: Discussionmentioning

confidence: 99%

“…There is, however, evidence from animal models that tolerable pain nonetheless has physiologic consequences, as rat dorsal horn neurons can be sensitized by repeated subthreshold synapse stimulation [ 8 ]. A body of evidence has illuminated the relationship between pain and autonomic function [ 9 , 10 ], and gastrointestinal function [ 11 ]. It is well recognized that gastric fundal accommodation and gastrointestinal motility are under the control of the autonomic nervous system [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Tolerable pain reduces gastric fundal accommodation and gastric motility in healthy subjects: a crossover ultrasonographic study

Hasuo

Kusunoki

Kanbara

et al. 2017

BioPsychoSocial Med

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BackgroundObstacles to pain management include patients’ reluctance to inform healthcare provides about their pain, and differences in the pain management aims between patients and healthcare providers. The objective of this study was to evaluate whether tolerable pain influences gastric fundal accommodation and gastric motility in healthy subjects.MethodsWe undertook a crossover comparison study to evaluate gastric fundal accommodation and gastric motility in 74 healthy subjects in the presence or absence of tolerable pain. The intensity of tolerable pain was defined as the upper limit of pain compatible with comfortable daily life. Pain was generated by clipping a clothes pin to the ear lobe, and the intensity of pain was adjusted by inserting the gauze between the ear lobe and the pin. Gastric fundal accommodation and gastric motility were assessed by external ultrasonography. The cross-sectional area of the proximal stomach was measured after subjects had taken 100 mL-liquid meals four times, then the amplitude and frequency of antral contractions were measured.ResultsThe median numerical rating scale of tolerable pain was 3 (interquartile rang 2–4). Gastric fundal accommodation, gastric motility and gastric emptying were all significantly impaired by tolerable pain (P < 0.001 for all comparisons).ConclusionsEven tolerable pain can reduce gastric fundal accommodation and gastric motility, which could result in anorexia or decreased quality of life. Our findings provide important insights into pain management education for patients tolerating pain and healthcare providers encouraging patients to tolerate pain. This study was registered retrospectively.

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“…To our surprise, we failed to identify such a correlation. To measure stress, we used the STAI, which is often used as a measure of psychological stress, and the salivary amylase level, which has been recently reported as a biological stress marker based on its correlation with stressful perception [39][40][41] . With the use of these measurements in mind, some explanations of the unexpected findings can be postulated.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Postoperative Ileus after Elective Colorectal Surgery

Suzuki

Ohata

Yamada

et al. 2017

JJCS

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The aim of this study was to determine whether various patient characteristics and perioperative clinical interventions might be correlated with the incidence of postoperative ileus (POI). Methods: We prospectively investigated 114 patients who were scheduled to undergo elective colorectal surgery. The associations of patient characteristics and clinical interventions with POI were examined statistically. We also included preoperative stress as a possible predictor of POI. Results: A total of 11 (9.7%) patients developed POI. Univariate analyses showed that an intraoperative remifentanil dose of ≥4.0mg was significantly associated with the occurrence of POI. Although a multivariate analysis showed that only an intraoperative remifentanil dose of ≥4.0 mg was statistically correlated with the occurrence of POI (p=0.0375), the risk for POI increased significantly with the number of other predictive factors present: a male sex, and an intraoperative remifentanil dose of ≥4.0 mg. A correlation between preoperative stress and the incidence of POI was not found. Conclusions: Our study suggests that an intraoperative remifentanil dose of ≥4.0 mg is a risk factor for POI and that the risk increases when it coexists with a male sex. Further study is needed to clarify the correlations among a

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Small correlation between salivary α‐amylase activity and pain intensity in patients with cancer pain

Cited by 14 publications

References 5 publications

Salivary Alpha-Amylase Activity: A Possible Indicator of Pain-Induced Stress in Orthodontic Patients

Salivary Alpha-Amylase Activity: A Possible Indicator of Pain-Induced Stress in Orthodontic Patients

Tolerable pain reduces gastric fundal accommodation and gastric motility in healthy subjects: a crossover ultrasonographic study

Risk Factors for Postoperative Ileus after Elective Colorectal Surgery

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