Small cell variant of anaplastic large cell lymphoma with leukemic presentation: a diagnostic challenge

Barrese, Tomás Zecchini; Sagramoso, Carlo; Bacci, Francesco; Sabattini, Elena

doi:10.1016/j.bjhh.2017.05.009

Cited by 4 publications

(6 citation statements)

References 30 publications

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“…In our cases, the leukocytosis was elevated to 118 × 10 9 /L. Extensive extranodal involvement is often reported in leukemic-phase ALCL, and central nervous system may be involved 9 …”

Section: Discussionsupporting

confidence: 43%

“…Leukemic involvement of ALCL is extremely rare, and to date, fewer than 40 well-documented cases have been reported in the literature 5–9 . Most leukemic cases are ALK + , and approximately 80% are associated with the t(2;5)(p23;q35) 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Leukemic involvement of ALCL is extremely rare, and to date, fewer than 40 well-documented cases have been reported in the literature. [5][6][7][8][9] Most leukemic cases are ALK + , and approximately 80% are associated with the t(2;5)(p23;q35). 7 There have also been reports of ALK − ALCL with leukemic involvement, including a recent case series of 9 cases.…”

Section: Discussionmentioning

confidence: 99%

“…Extensive extranodal involvement is often reported in leukemic-phase ALCL, and central nervous system may be involved. 9 The leukemic phase of ALK + ALCL is most often associated with the small-cell variant of ALCL. 7,10,11 In the lymph node, this morphologic pattern shows a predominance of small cells, admixed with rare hallmark cells, and can be misdiagnosed as peripheral T-cell lymphoma, not otherwise specified.…”

Section: Discussionmentioning

confidence: 99%

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Leukemic Presentation of Anaplastic Large Cell Lymphoma: A Diagnostic Challenge Mimicking T-Cell Prolymphocytic Leukemia

Vadasz¹,

Wolniak²,

Sukhanova³

et al. 2022

AJSP: Reviews and Reports

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Anaplastic large cell lymphoma (ALCL) is a rare systemic T-cell neoplasm that typically involves nodal and extranodal sites and is further classified into 2 subgroups: anaplastic lymphoma kinase (ALK-) positive (ALK + ) and ALK-negative. Leukemic presentation of ALCL is extremely rare. Most cases with leukemic presentation are the small-cell variant of ALK + ALCL, are positive for the t(2;5)(p23;q35) translocation, and are associated with a poor prognosis. We report a case of ALK + ALCL that presented with a high white blood cell count and morphologic and phenotypic features resembling T-cell prolymphocytic leukemia.

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“…In our cases, the leukocytosis was elevated to 118 × 10 9 /L. Extensive extranodal involvement is often reported in leukemic-phase ALCL, and central nervous system may be involved 9 …”

Section: Discussionsupporting

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Leukemic Presentation of Anaplastic Large Cell Lymphoma: A Diagnostic Challenge Mimicking T-Cell Prolymphocytic Leukemia

Vadasz¹,

Wolniak²,

Sukhanova³

et al. 2022

AJSP: Reviews and Reports

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“…ALC has three main subtypes: systemic ALCL, primary cutaneous ALCL, and breast implant-associated ALCL. Systemic ALCL can be either ALK-positive or ALK-negative, while primary cutaneous ALCL and breast implant-associated ALCL are typically ALK-negative [ 6 ]. Lymphoma in the pancreas is a very rare clinical entity; primary pancreatic lymphoma (PPL) represents <0.5% of pancreatic cancers and 1% of extranodal lymphomas [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Extranodal Anaplastic Large Cell Lymphoma Involving the Pancreas: A Rare Presentation

Alsaleem,

Almuzaini,

Alnafisah

et al. 2024

Cureus

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Anaplastic large-cell lymphoma (ALCL) is a subtype of T-cell lymphoma. This disease mainly affects lymph nodes, although extranodal sites may also be involved. Lymphoma in the pancreas is a rare clinical entity whether it manifests as primary or extranodal involvement. We discuss an unusual case of a 29-year-old male patient who presented with epigastric pain and a right neck mass. The patient’s symptoms, physical examination, and laboratory tests prompted further investigation using imaging modalities such as CT, MRI, and endoscopic ultrasound, which revealed the presence of soft tissue masses in the right supraclavicular region and an ill-defined lesion within the pancreatic head. These findings eventually led to the identification of secondary extranodal pancreatic lymphoma. Fine needle biopsy (FNB) established an ultimate diagnosis of anaplastic lymphoma kinase (ALK)-positive ALCL.

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Anaplastic Large Cell Lymphoma in Children and Adolescents

Lowe¹,

Brugières²

2019

Non-Hodgkin's Lymphoma in Childhood and Adolescence

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Small cell variant of anaplastic large cell lymphoma with leukemic presentation: a diagnostic challenge

Cited by 4 publications

References 30 publications

Leukemic Presentation of Anaplastic Large Cell Lymphoma: A Diagnostic Challenge Mimicking T-Cell Prolymphocytic Leukemia

Leukemic Presentation of Anaplastic Large Cell Lymphoma: A Diagnostic Challenge Mimicking T-Cell Prolymphocytic Leukemia

Extranodal Anaplastic Large Cell Lymphoma Involving the Pancreas: A Rare Presentation

Anaplastic Large Cell Lymphoma in Children and Adolescents

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