Anaplastic Large Cell Lymphoma in Children and Adolescents

Lowe, Eric; Brugières, Laurence

doi:10.1007/978-3-030-11769-6_20

Cited by 5 publications

(9 citation statements)

References 96 publications

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“…Current trials incorporate these drugs into first-line therapy, which will likely change treatment paradigms for this disease and further improve long-term outcomes. 20 Our patient had no involvement of her bone marrow or central nervous system, and she had no skin lesions. Her signs and symptoms resolved quickly with chemotherapy, with a complete response after 2 chemotherapy cycles.…”

Section: Dr Belyeamentioning

confidence: 61%

“…Most patients present at advanced stages, with primary abdominal or mediastinal disease. 20 They often have systemic signs and symptoms (fever, weight loss, and night sweats) and frequently have extranodal disease in skin, liver, lung, soft tissues, and bone. 21 These inflammatory symptoms can be troubling yet nonspecific.…”

Section: Dr Belyeamentioning

confidence: 99%

“…Various regimens have been used to treat ALCL with good success. 20 Current regimens involve 6 cycles of alternating agents, typically including dexamethasone, ifosfamide, cyclophosphamide, methotrexate, etoposide, cytarabine, and doxorubicin. Typical side effects include neutropenia, mucositis, nausea and/or vomiting, and anemia.…”

Section: Dr Belyeamentioning

confidence: 99%

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Abdominal Pain and Intermittent Fevers in a 16-Year-Old Girl

Penberthy¹,

Mendoza²,

Mendoza³

et al. 2019

Pediatrics

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A 16-year-old girl presented to the emergency department with intermittent fevers and worsening abdominal pain of 5 weeks duration. She had a history of travel to a less developed country and exposure to possible infectious diseases. Abdominal imaging and blood tests revealed diffuse mesenteric lymphadenopathy, elevated transaminases, and elevation of inflammatory markers. Gastroesophageal and colon endoscopies revealed gastric ulcers, and the patient was discharged with a presumptive diagnosis of systemic juvenile idiopathic arthritis given the lymphadenopathy seen on imaging, serositis, sacroiliac joint stiffness noted on physical examination, and pain relief with celecoxib. She presented again 4 days later with worsening abdominal tenderness, elevated transaminases, and new-onset abdominal distention. Tissue biopsy yielded the diagnosis and directed appropriate treatment.

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Section: Dr Belyeamentioning

confidence: 61%

Section: Dr Belyeamentioning

confidence: 99%

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Abdominal Pain and Intermittent Fevers in a 16-Year-Old Girl

Penberthy¹,

Mendoza²,

Mendoza³

et al. 2019

Pediatrics

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“…[3][4][5]8,11 However, when compared to the approximately 70% survival rate for pediatric ALCL, the most common and well-studied mature T-cell lymphoma in children, PNKTCL shows a worse prognosis, although the case series by Kobayashi et al 4 exhibited a high ALCL-like survival rate of 85%. 21 When examining their data, these better outcomes may have resulted from having a lower rate of EBV infection. Also, their data set contained no cases of systemic EBV-positive TCLC, an entity with dismal survival that would surely bring down the overall mortality rate.…”

Section: A Diagnosis Of Exclusion Ptcl-nos Includes a Heterogenous Smentioning

confidence: 99%

Primary Nonanaplastic Peripheral Natural Killer/T-Cell Lymphoma in Pediatric Patients—An Unusual Distribution Pattern of Subtypes

Wilberger

Liang

2018

Pediatr Dev Pathol

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Peripheral NK/T-cell lymphoma (PNKTCL) represents a group of uncommon diagnoses for children in Western countries, and studies have often necessitated multiple institutions to assemble enough cases. We retrospectively analyzed 11 cases of nonanaplastic PNKTCL in children over 19 years at our institution with comparison to several published large multiinstitutional studies. Patients included 9 males and 2 females of white (5), Native American (3), and Hispanic (3) background with 6 cases of extranodal NK/T-cell lymphoma, nasal type (EN-NKTL, 54.6%), 3 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS, 27.2%), and 2 cases of systemic Epstein-Barr virus (EBV)-positive T-cell lymphoma of childhood (18.2%). Compared to the literature, our institution exceeded in frequency of total nonanaplastic PNKTCL (4.8% vs 0.9%-1.6%) with lesser relative incidence of PTCL-NOS (27.2% vs 42.9%-66.7%) and greater relative incidence of EN-NKTL (54.6% of cases vs 12.5%-47.6%), which significantly exceeded the literature's rate for Western institutions (13.5%). Potential influencing factors include population structure approximating those of non-Western countries with high EN-NKTL prevalence and the predisposition for EBV infection in this demography. These data suggest an uneven distribution of nonanaplastic PNKTCL in Western countries, and differential diagnoses may differ depending on practice location and associated patient population.

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“…Anaplastic large cell lymphoma (ALCL) accounts for 20-30% of childhood non-Hodgkin lymphoma (NHL) 1,2 and often presents with advanced-stage disease. Disease recurrence develops in 20%-40% of patients.…”

Section: Introductionmentioning

confidence: 99%

Central nervous system relapse in a child with anaplastic large cell lymphoma: potential for new therapeutic strategies

et al. 2021

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Background: Central nervous system (CNS) relapse is rare in childhood anaplastic large cell lymphoma (ALCL) and is associated with a poor prognosis. Case:We describe an 8-year-old boy with ALCL who developed an early CNS relapse without initial CNS disease. Despite aggressive medical management, the patient's neurological status deteriorated rapidly and he died shortly after. Conclusion:Optimal treatment for children with relapsed ALCL involving the CNS remains unclear. Novel agents, including ALK inhibitors, that have CNS-penetration might be helpful and pediatric studies are warranted.

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Anaplastic Large Cell Lymphoma in Children and Adolescents

Cited by 5 publications

References 96 publications

Abdominal Pain and Intermittent Fevers in a 16-Year-Old Girl

Abdominal Pain and Intermittent Fevers in a 16-Year-Old Girl

Primary Nonanaplastic Peripheral Natural Killer/T-Cell Lymphoma in Pediatric Patients—An Unusual Distribution Pattern of Subtypes

Central nervous system relapse in a child with anaplastic large cell lymphoma: potential for new therapeutic strategies

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