Small-cell undifferentiated carcinoma of the colon

Mills, Stacey E.; Allen, M. Shannon; Cohen, Asaf

doi:10.1097/00000478-198310000-00005

Cited by 104 publications

(26 citation statements)

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“…Their distribution in the colon-rectum resembles that of con ventional adenocarcinomas. An origin for such neoplasms in conventional colonic adenomas has been described by Mills et al [ 117]. By light microscopy, the cells are smallto-intermediate in size, arranged in groups with extensive necrosis.…”

Section: Benign or Low-grade Malignant Behaviormentioning

confidence: 91%

“…The classification of the neuroendocrine tumors of the colon and rectum is based on the studies of Berardi [112], Gould and Chejfec [113], Fiocca et al [114], Alumets et al [115], O'Briain et al [116], Mills et al [117], and Wick et al [118]. According to these studies at least three main types of neuroendocrine tumors have been identified: Lcell tumors producing glicentin-related peptides and PP-PYY, EC-cell tumors producing serotonin and substance P, and poorly differentiated (small-cell) carcinomas (ta ble 7).…”

Section: Colon and Rectum Tumorsmentioning

confidence: 99%

See 1 more Smart Citation

Revised Classification of Neuroendocrine Tumors of the Lung, Pancreas and Gut

Capella

Heitz²,

Höfler³

et al. 1994

Digestion

183

140

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The general use of the term carcinoid for the classification of neuroendocrine tumors has become increasingly difficult during recent years. First, its definition and prognosis varies from site to site. Second, its traditional definition does not cover the whole morphological and biological spectrum of neuroendocrine tumors known today. We therefore propose new classifications of the neuroendocrine tumors of the lung, pancreas, stomach, duodenum, jejunum-ileum, appendix and colorectum. These classifications use a common framework and attempt to consider the morphological, functional and biological features of these tumors.

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Section: Benign or Low-grade Malignant Behaviormentioning

confidence: 91%

Section: Colon and Rectum Tumorsmentioning

confidence: 99%

Revised Classification of Neuroendocrine Tumors of the Lung, Pancreas and Gut

Capella

Heitz²,

Höfler³

et al. 1994

Digestion

183

140

View full text Add to dashboard Cite

show abstract

“…The authors of all reports to date have drawn a parallel with 'oat cell' carcinoma of the lung and of other organs but expressed differing views on histogenesis. Nine of 24 cases reported so far arose in close association with a villous or tubulo-villous adenoma (Mills et al 1983, Palvio et al 1985, Molas et al 1987, Wicket al 1987, Chen 1989.…”

Section: Introductionmentioning

confidence: 99%

“…A number of reports have appeared in recent years of seemingly undifferentiated and rapidly fatal colonic tumours under a variety of names: 'neuroendocrine carcinoma' (Gould & Chejfec 1978), 'small cell undifferentiated carcinoma' (Mills, Allen & Cohen 1983, Wick, Weatherby & Weiland 1987, 'stem cell carcinoma' (Palvio, Ssrensen & K10ve-Mogensen 1985) or a combination of such terms (Molas, Bougis-de-Brux & Potet 1987, Chen 1989. The authors of all reports to date have drawn a parallel with 'oat cell' carcinoma of the lung and of other organs but expressed differing views on histogenesis.…”

Section: Introductionmentioning

confidence: 99%

Small cell undifferentiated (‘neuroendocrine’) carcinoma of the colon

Sarsfield

Anthony

1990

Histopathology

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Three patients are described who presented with a large colonic adenoma in which a solid, undifferentiated carcinomatous component was found on microscopic examination. Despite small size (1.0 and 1.5 cm) and submucosal location in two cases, the tumours had metastasized to regional lymph nodes and the liver and death ensued at 4, 11 and 18 weeks after surgery. Immunocytochemistry was positive for carcino-embryonic antigen, low molecular weight cytokeratins and neuron specific enolase in all three cases and scanty dense core granules of neurosecretory type were found in one of two examined by electron microscopy. These 'neuroendocrine' carcinomas are compared with 'pure' adenomas and 'ordinary' poorly differentiated adenocarcinomas of the colon from which they differ, mainly by lack of glandular differentiation and mucus secretion, although two adenocarcinomas also showed patchy reactivity for neuron specific enolase. The term 'neuroendocrine' may be disputed but is now well established to describe a tumour that runs a uniquely aggressive course and for which radical surgery alone cannot provide a cure.

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“…Small cell carcinoma of the rectum occurring on its own was described [4,12]. In addition, large cell neuroendocrine carcinoma of the rectum was also documented [2].…”

Section: Discussionmentioning

confidence: 99%

Composite adenocarcinoma and large cell neuroendocrine carcinoma of the rectum

2006

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Composite glandular-endocrine tumors of the gastrointestinal tract are rare neoplasms. Even more uncommon are the so-called amphicrine tumors, lesions in which dual epithelial and endocrine differentiation occurs in the same cell. We describe a patient who complained of rectal pain and bleeding with a mixed or composite adenocarcinoma and neuroendocrine carcinoma of the rectum. Histological examination revealed a distinct adenocarcinoma of conventional type with glandular structures admixed intimately with a neuroendocrine carcinoma. The latter component was deeply infiltrative, while the adenocarcinoma occupied the more superficial aspect of the tumor. What was interesting was the immunophenotype of the lesion: cytokeratin (CK) 20 expression was very focal in the adenocarcinoma component and negative in the neuroendocrine carcinoma, while CK 7 was expressed strongly in the adenocarcinoma and only focally in the neuroendocrine component. This cytokeratin profile suggests a possible origin from the anal transitional zone.

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Small-cell undifferentiated carcinoma of the colon

Cited by 104 publications

References 0 publications

Revised Classification of Neuroendocrine Tumors of the Lung, Pancreas and Gut

Revised Classification of Neuroendocrine Tumors of the Lung, Pancreas and Gut

Small cell undifferentiated (‘neuroendocrine’) carcinoma of the colon

Composite adenocarcinoma and large cell neuroendocrine carcinoma of the rectum

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