Small Cell (Neuroendocrine) Carcinoma of the Prostate: Etiology, Diagnosis, Prognosis, and Therapeutic Implications—A Retrospective Study of 30 Patients From the Rare Cancer Network

Stein, Moshe; Kuten, Abraham; Bernstein, Zvi; Abacıoğlu, Ufuk; Şengöz, Meriç; Miller, Robert C.; Meirovitz, A.; Zouhair, A.; Freixa, Salvador Villà; Poortmans, P.; Ash, Robert B.

doi:10.1097/maj.0b013e3181731e58

Cited by 54 publications

(58 citation statements)

References 42 publications

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“…Extrapulmonary scc has been described in various organs, including these genitourinary (gu) tract sites [2][3][4][5][6][7][8][9] : the urinary bladder (ub), which is the most common site for gu scc; the prostate; and the upper urinary tract (uut), including the ureters and kidneys 5,6,9 .…”

Section: Introductionmentioning

confidence: 99%

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Genitourinary Small-Cell Carcinoma: A Single-Institution Experience

et al. 2013

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Section: Introductionmentioning

confidence: 99%

“…Available knowledge is based mainly on small retrospective series and case reports [2][3][4][5][6][7][8][9] . Because no randomized trials have studied patients with gu scc, there is no standard approach for managing the malignancy.…”

Section: Introductionmentioning

confidence: 99%

Genitourinary Small-Cell Carcinoma: A Single-Institution Experience

et al. 2013

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“…None of the patients in the series were taken to radical prostatectomy, with two patients undergoing transurethral resection for obstructive disease palliative management. This data underscores the need for new therapeutic strategies to treat these tumors, which may include the use of protocols that have been effective against neuroendocrine carcinomas arising in other organ systems (6,(12)(13)(14).…”

Section: Discussionmentioning

confidence: 96%

Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center

et al. 2011

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Purpose: Neuroendocrine carcinomas (NEC) of the prostate are rare, with only a few series hitherto reported. The objective of this study was to assess in a single institution the clinical and morphologic characteristics of neuroendocrine carcinomas diagnosed in needle core biopsies. Materials and Methods:The current study analyses seven cases diagnosed in needle biopsies at a large tertiary regional cancer center from Northeastern Brazil. Two pathologists reviewed specimens retrospectively, and demographic and morphologic characteristics were compared to 458 acinar tumors diagnosed in the same period. Results: There were five small cell carcinomas and two low-grade neuroendocrine carcinomas (carcinoid). NEC were associated with an acinar component in 5/7 cases and the Gleason score of the acinar component was always > 6. The number of cores involved in prostates with NEC was greater (65% compared to 24% of acinar tumors, p < 0.05). The mean PSA at diagnosis was 417.7 (range 5.7-1593, SD 218.3), compared to 100.5 (p = 0.1) of acinar tumors (range 0.3-8545, SD 22.7). Prostates harboring NEC were bigger (p < 0.001, mean volume 240 mL vs. 53 mL of acinar tumors). Treatment of NEC included palliative surgery, chemotherapy, and hormonal therapy. Conclusions: NEC of the prostate is rare and often associated with a high-grade acinar component. Prostates with NEC tend to be larger and involve a greater number of cores than acinar tumors. PSA at diagnosis does not seem to predict the presence of NE tumors in needle biopsy.

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“…Its role is palliative, as it may control local symptoms, such as complications of brain and bone metastases. [8] Regarding irradiation, no exact guidelines for the total dose or irradiation volume have been suggested. Because of the disease propensity for local and pelvic lymph node relapse, the treatment volume should include the pelvic lymph nodes, with a dose between 45 and 55 Gy (daily dose 1.8 Gy), followed by a boost to the prostate volume, which in some studies may reach a total dose of 72 Gy.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the disease propensity for local and pelvic lymph node relapse, the treatment volume should include the pelvic lymph nodes, with a dose between 45 and 55 Gy (daily dose 1.8 Gy), followed by a boost to the prostate volume, which in some studies may reach a total dose of 72 Gy. [8] The paradigm for the multimodal treatment of SCPCa is derived from the treatment for lung SCC and is consistent with cisplatin-based chemotherapy and radiation therapy. [5,9] Various regimens adding cisplatin as the main agent have been used, including etoposide, cyclophosphamide, doxorubicin and vincristine; carboplatin and etoposide; carboplatin and taxanes; and cisplatin, ifosfamide, and etoposide.…”

Section: Discussionmentioning

confidence: 99%

Pure small cell carcinoma of the prostate: case report

Ati̇lla¹,

Şahin²,

Bakırtaş³

et al. 2012

Turkish Journal of Urology

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Extrapulmonary small cell carcinoma arising in the prostate gland has been described in several case series and case reports. However, pure small cell carcinoma of the prostate is rare, and there are only a few reports in the literature describing the clinical features and management of this neoplasm. These tumors are highly aggressive and commonly manifest with visceral metastasis at the time of diagnosis. This report describes the diagnosis and management of a 73-year-old patient with small cell carcinoma of the prostate in light of the reviewed literature.

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Small Cell (Neuroendocrine) Carcinoma of the Prostate: Etiology, Diagnosis, Prognosis, and Therapeutic Implications—A Retrospective Study of 30 Patients From the Rare Cancer Network

Cited by 54 publications

References 42 publications

Genitourinary Small-Cell Carcinoma: A Single-Institution Experience

Genitourinary Small-Cell Carcinoma: A Single-Institution Experience

Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center

Pure small cell carcinoma of the prostate: case report

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