Genitourinary Small-Cell Carcinoma: A Single-Institution Experience

Abstract

no standard of care, patients should be treated using a multimodality approach analogous to that used in the treatment of small-cell lung cancer.

Response to: “Small-Cell Carcinoma of the Genitourinary Tract: A Point of View”

“…I noted a 50% rate of brain metastasis reported by the MD Anderson group 2 in stage iii and iv patients. That rate of brain metastasis is higher than the rate observed in our report and in other published retrospective studies 1,3 .I concur with Dr. Ismaili that the optimal management of small-cell carcinoma of the prostate is not well defined. However, we suggest limiting the use of androgen deprivation therapy in a mixed histology of scc and adenocarcinoma.…”

“…I noted a 50% rate of brain metastasis reported by the MD Anderson group 2 in stage iii and iv patients. That rate of brain metastasis is higher than the rate observed in our report and in other published retrospective studies 1,3 .…”

“…I thank Dr. Nabil Ismaili for reading our article 1 and giving his valuable comments with regard to the management of genitourinary small-cell carcinoma (scc). Dr. Ismaili agrees with us about the essential role of chemotherapy in the management of genitourinary scc.…”

Small-Cell Carcinoma of the Genitourinary Tract: A Point of View

“…We read with great interest the article by Pervez et al 1 about genitourinary (gu) small-cell carcinoma (scc). The authors studied an important issue: management of gu scc, a rare and highly aggressive disease.…”

“…The authors conclude that patients with gu scc should be treated using a multimodality approach including chemotherapy analogous to that for the treatment of small-cell lung cancer 1 . We agree that chemotherapy plays a critical role in the treatment of this systemic disease.…”