Small cell neuroendocrine carcinoma of the ureter: A case report and literature review

Jiang, Ping; Chen, Zhang Xiao; Qian, Jun; Han, You; Xu, Nong

doi:10.3892/ol.2013.1757

Cited by 22 publications

(41 citation statements)

References 12 publications

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“…8 Most primary neuroendocrine tumors of the ureter occur in the sixth to seventh decade of life, and there does not appear to be a gender predilection. 3,4 Our patient thus demonstrated the classically reported clinical features; however, the age was premature. Although the symptoms that our patient presented with may be classic in patients with neuroendocrine tumors of the upper urinary tract, benign diseases by far are a more common cause of such symptomatology.…”

Section: Discussionsupporting

confidence: 69%

“…Overall, pain and hematuria are the most common initial symptoms. 3,4 However, unlike urothelial carcinomas, locally advanced or nodal disease at presentation is common, with an estimated 20%–45% of patients harboring advanced disease at the time of diagnosis 5,6 —these findings are in line with the aggressive behavior demonstrated by neuroendocrine tumors arising from other sites. 7 …”

Section: Discussionmentioning

confidence: 88%

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Neuroendocrine Tumor of the Ureter: A Zebra Among Horses

Sood

Williamson

Leavitt

2016

Journal of Endourology Case Reports

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Primary neuroendocrine tumors of the upper urinary tract are extremely rare. We report a case of de novo small cell carcinoma of the ureter that presented masquerading as a distal ureteral stone. A 55-year-old lady presented to our clinic with 1 month history of right lower back pain and hematuria. Her history was notable for stage 1B mixed clear cell-endometroid cancer of the uterus status post radical abdominal hysterectomy with adjuvant radiotherapy, 7 years before the current episode. The patient had no evidence of recurrence. Initial noncontrast imaging suggested a 2.5 mm calculus in the distal right ureter and hydronephrosis; however, ureteroscopy revealed a large fleshy mass at the location. Histopathologic evaluation demonstrated the lesion to be primary small cell carcinoma of the ureter, without evidence of it being a derivative of the prior gynecologic malignancy. Metastatic work-up revealed high burden retroperitoneal adenopathy. The patient was started on Cisplatin-based neoadjuvant chemotherapy with plan for nephroureterectomy in the future. At 3 months follow-up, the patient was doing well with significant shrinkage of retroperitoneal adenopathy and no evidence of disease progression.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 88%

Neuroendocrine Tumor of the Ureter: A Zebra Among Horses

Sood

Williamson

Leavitt

2016

Journal of Endourology Case Reports

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“…Hypothetically, ureteral SCC may originate from the multipotent stem cells of the urothelium or intrinsic neuroendocrine cells present in the ureteral urothelium with neuroendocrine differentiation. 24 Most authors supported the hypothesis that EPSCC originates from multipotent stem cells. 32 In fact, almost half of the patients (46.9%) had other tumor components such as UC and squamous cell carcinoma, which buttresses the hypothesis of the origin of multipotent stem cells.…”

Section: Discussionmentioning

confidence: 83%

Clinicopathologic characteristics, therapy and outcomes of patients with primary ureteral small cell carcinoma: a case series and systematic review of the literature

Zhong¹,

Lin²,

Zhang³

et al. 2017

OTT

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PurposeThe aim of this case series was to review the standard diagnosis and treatment procedures of primary small cell carcinoma (SCC) in our institution and discuss the clinicopathologic characteristics, treatments and outcomes of patients with primary ureteral SCC.Patients and methodsPatients diagnosed with ureteral SCC in Peking University First Hospital, Beijing, China, from January 2007 to December 2016 were included. In addition, we performed a systematic literature review, in October 2016, on case reports and case series of ureteral SCC. The clinicopathologic characteristics, treatments and outcomes of this rare disease were analyzed.ResultsA total of 32 patients were included in our analysis (4 cases from our institution and 28 cases from the literature). Most patients (71.0%) were male with an average age of 66.6 years (range 48–80 years). The most common symptoms were hematuria (n=14, 48.3%) and flank pain (n=14, 48.3%). All patients underwent surgery, with 12 (37.5%) patients undergoing multimodality therapy. Regional or distant recurrences developed in 11 patients, among which only 1 patient had bladder recurrence. The overall median survival of the patients was 17 months, with 1- and 3-year survival rates of 51.9% and 30.3%, respectively. In a univariate analysis, female (P=0.009), pure SCC (P=0.03) and advanced T stage (P=0.04) were associated with worse overall survival.ConclusionUreteral SCCs are extremely rare neoplasms with aggressive natural history and poor prognosis. T stage, tumor components and gender may be important factors influencing prognosis. A multimodality treatment is recommended for management. However, further studies are needed to improve the treatment strategy.

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“…In these cases they are usually found in the bladder, and are mostly aggressive with a potential to invade surrounding tissue and vascular structures 1–3. This makes the ureter an extremely rare site for neuroendocrine carcinomas, hence scarce reporting in the world literature; we estimate there have been less than 30 cases reported to date1–10…”

Section: Discussionmentioning

confidence: 99%

Incidental finding of a small cell neuroendocrine carcinoma of the ureter

Obi-Njoku¹,

Bell

Menon

et al. 2019

BMJ Case Rep

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The ureter is an extremely rare site for small cell neuroendocrine carcinoma. We present a case of this disease in a patient who presented without urological symptoms. The multidisciplinary team proposed nephroureterectomy (if fit) or watchful waiting as management. After discussion with the patient a decision in favour of watchful waiting was made. We report her case including a review of the literature, and emphasise that although small cell neuroendocrine carcinomas can be very aggressive, they can remain asymptomatic.

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Small cell neuroendocrine carcinoma of the ureter: A case report and literature review

Cited by 22 publications

References 12 publications

Neuroendocrine Tumor of the Ureter: A Zebra Among Horses

Neuroendocrine Tumor of the Ureter: A Zebra Among Horses

Clinicopathologic characteristics, therapy and outcomes of patients with primary ureteral small cell carcinoma: a case series and systematic review of the literature

Incidental finding of a small cell neuroendocrine carcinoma of the ureter

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