Small Cell Lung Cancer with Extensive Cutaneous and Gastric Metastases.

Abstract

A case of a 6Q-year-old Japanese woman with small cell lung cancer involving skin and stomach is reported. She was diagnosed as primary small cell lung cancer accompanied by extensive cutaneous metastases. Three months after the last chemotherapy, she complained of nausea and vomiting. Brain CT scan showed no evidence of central nervous system involvement. Upper gastrointestinal study and upper gastrointestinal fiberscopy revealed multiple metastatic gastric tumors. Skin and stomach are uncommon metastatic sites for any malignancy. Furthermore, only a few cases with gastric metastasis could be diagnosed during their lifetime.

Gastric Metastases from Lung Adenocarcinoma Causing Gastrointestinal Bleeding

“…Hematogenous metastases to the stomach are rare, despite its rich blood supply, with a postmortem incidence of 0.2–9% 2,6,10,11. In most studies, breast cancer, malignant melanoma, and lung cancer were the most common malignancies metastasizing to the stomach 10-12.…”

“…In most studies, breast cancer, malignant melanoma, and lung cancer were the most common malignancies metastasizing to the stomach 10-12. The rarity of stomach metastases is poorly understood.…”

“…The rarity of stomach metastases is poorly understood. One hypothesis suggests that certain cytokines may affect the organ specificity in hematogenous metastases 10. Hematogenous metastases to the stomach are usually submucosal 10.…”

“…One hypothesis suggests that certain cytokines may affect the organ specificity in hematogenous metastases 10. Hematogenous metastases to the stomach are usually submucosal 10. The macroscopic appearance of these submucosal gastric metastasis has been described radiographically as a bull’s eye sign and endoscopically as volcano-like or umbilicated on the tip 3,4,10,13.…”

Skin Metastasis in a patient with Small-Cell Lung Cancer

“…Common metastatic sites include lung, liver, bone, adrenal gland and central nervous system. 19 Cutaneous metastases from the lung are not very common and indicate a poorer prognosis. The percentage of patients with lung cancer who develop skin metastasis ranges from 1-12%.…”