Small Cell Lung Cancer: Time To Diagnosis And Treatment

Haque, Niaz; Raza, Ali; McGoey, Robin; Boulmay, Brian C.; Diethelm, L; Kantrow, Stephen P.

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5151

Cited by 6 publications

(14 citation statements)

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“…S5), 514 from MEDLINE, 72 from the Cochrane Library and an additional 12 papers identified from reference lists. Of these, 11 papers were reviewed. Studies varied by publication date (2000–2013) and size ( n = 21–10 583) and reported data for a heterogeneous group of patients (stages I–IV non‐small‐cell lung cancer (NSCLC) and limited‐ and extensive‐stage small‐cell lung cancer (SCLC)) as shown in Tables and .…”

Section: Methodsmentioning

confidence: 99%

“…All three studies in SCLC retrospectively evaluated either institutional or registry data sets . No study reported an association between TTC and negative patient outcomes.…”

Section: Methodsmentioning

confidence: 99%

“…TTC in the setting of limited or extensive‐stage SCLC has not been demonstrated to impact overall survival . One study actually demonstrated an inverse relationship with poorer outcomes for those with the shortest TTC interval, likely reflecting the more urgent treatment of patients with significant symptoms and poor tumour biology.…”

Section: Methodsmentioning

confidence: 99%

“…This explains the large variance in the TTC threshold utilised for survival analysis (<15 vs >15 days compared with <42 vs >42 days). When comparing similar TTC intervals across the three studies (not necessarily used in survival analyses), variance is reduced, and intervals are shorter; median diagnosis to treatment interval was 6 and 13 days, and median oncologist to treatment interval was 15 days …”

Section: Methodsmentioning

confidence: 99%

“…Upon appropriate investigations, including biopsy and staging, chemotherapy should be commenced immediately. Outside of an emergency presentation, studies from clinical practice settings have demonstrated that patients with SCLC routinely commence chemotherapy rapidly (within 6–15 days) from the time of diagnosis or oncologist review . This is a sensible practice given the rapid progression in the absence of treatment.…”

Section: Methodsmentioning

confidence: 99%

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Timely initiation of chemotherapy: a systematic literature review of six priority cancers – results and recommendations for clinical practice

Alexander

Blum

Burbury

et al. 2017

Internal Medicine Journal

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This review evaluated the association between time-to-chemotherapy (TTC) and survival in six priority cancers. A systematic review of the literature was undertaken for papers indexed in the MEDLINE and Cochrane Library databases from the earliest index until April 2014. The methodology used has been published in a separate paper (Guidelines for timely initiation of chemotherapy: a proposed framework for access to medical oncology and haematology cancer clinics and chemotherapy services). The optimal timing of chemotherapy in breast cancer is unclear as available studies are of low quality, report inconsistent results and are limited to the adjuvant setting. However, increased TTC may have a negative prognostic impact, and delays beyond 4 weeks should be avoided. Studies suggest that the optimal timing for initiation of adjuvant chemotherapy for surgically resected colorectal cancer is 4-8 weeks post-surgery. Timing of chemotherapy for metastatic colorectal cancer does not influence survival. There is a paucity of studies to guide the timing of chemotherapy for the treatment of lymphoma and myeloma; no definitive conclusions can be drawn, and clinician discretion should be applied. The optimal timing of chemotherapy in lung cancer is unclear; however, rapid tumour growth and poor disease prognosis suggest that delays should be avoided wherever possible. The optimal timing of chemotherapy in ovarian cancer is unclear as available studies are of low level, report inconsistent results and are limited to the post-surgery setting; however, increased TTC may have a negative prognostic impact; therefore, delays beyond 4 weeks should be avoided.

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Section: Methodsmentioning

confidence: 99%

“…All three studies in SCLC retrospectively evaluated either institutional or registry data sets . No study reported an association between TTC and negative patient outcomes.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Timely initiation of chemotherapy: a systematic literature review of six priority cancers – results and recommendations for clinical practice

Alexander

Blum

Burbury

et al. 2017

Internal Medicine Journal

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Efficient solution of an inverse problem in cell population dynamics

2011

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In this paper, a size-structured model for cell division is examined and the question of determining the division (birth) rate from a measurable stable size distribution of the population is addressed. This inverse problem can be formulated as a differential-dilation equation. We propose a novel solution scheme based on mollification. The method of approximate inverse allows us to shift the derivative from the data to a precomputable reconstruction kernel. To comprise all available a priori information, a presmoothing step based on regression in reproducing kernel Hilbert spaces is introduced. We establish an error theory for the emerging algorithm, prove convergence and deduce a parameter strategy. The results are substantiated with extensive numerical tests both for artificial and real data based on proliferating tumor cells.

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H Προγνωστική Σημασία Των Κυκλοφορούντων Διαλυτών Μορίων Προσκόλλησης Σε Ασθενείς Με Μικροκυτταρικό Καρκίνο Πνεύμονα

Κοττέας¹

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Σκοπός: Η επιθηλιακή Ε-καντερίνη, το διακυτταρικό μόριο προσκόλλησης-1 (ΙCAM-1), τοαγγειακό μόριο προσκόλλησης-1 (VCAM-1) και η ενδοθηλιακή Ε-σελεκτίνη, είναιδιαμεμβρανικές γλυκοπρωτεΐνες, που συμμετέχουν στη διαδικασία της εμβρυογένεσης, στηδιατήρηση της δομής των ιστών, στη λειτουργία του ανοσοποιητικού συστήματος, στηναγγειογένεση. Η έκφρασή τους έχει αποδεικτεί ότι κατέχει σημαντικό ρόλο στηνκαρκινογένεση και στην εξέλιξη των νεοπλασιών. Η παρούσα προοπτική μελέτη εξέτασε τηνπρογνωστική σημασία των προαναφερόμενων μορίων προσκόλλησης στον μικροκυτταρικόκαρκίνο του πνεύμονα. Μέθοδοι: Συγκεντρώθηκαν δείγματα αίματος από 50νεοδιαγνωσθέντες ασθενείς με μικροκυτταρικό καρκίνο πνεύμονα καθώς και από 27 υγιείςμάρτυρες. Tα επιπεδα μετρήθηκαν με μέθοδο ELISA. Έγινε συσχέτιση των αποτελεσμάτωνμε τα χαρακτηριστικά των ασθενών, με την επιβίωση και με τις ανταποκρίσεις των ασθενώνστην χημειοθεραπεία. Αποτελέσματα: Διαπιστώθηκε στατιστικά σημαντική αύξηση τωνεπιπέδων όλων των εξετασθέντων μορίων των ασθενών κατά την διάγνωση συγκριτικά με τιςτιμές των μαρτύρων (p<0.001). Εκτός του σταδίου και του δείκτη λειτουργικής ικανότητας, ταεπίπεδα ICAM-1 (HR: 1.005, 95% CI 1.002-1.009, p=0.041) και Ε-σελεκτίνης (HR: 1.007,95% CI 1.003-1.014, p=0.021) ήταν ανεξάρτητοι προγνωστικοί παράγοντες επιβίωσης στους12 μήνες από την διάγνωση. Επιπλέον, οι ασθενείς που είχαν μείωση των επιπέδων τουICAM-1 κατά 20% στο μέσο και κατά 19% στο τέλος της χημειθεραπείας σε σχέση με τααρχικά τους επίπεδα, εμφάνισαν αντικειμενικές ανταποκρίσεις (p=0.001 και p=0.012αντίστοιχα). Συμπεράσματα: Με τα σημαντικά αυξημένα επίπεδα όλων των εξετασθέντωνδιαλυτών μορίων στην διάγνωση των ασθενών αποδεικνύεται η συμμετοχή τους στην εξέλιξητου μικροκυτταρικού καρκίνου του πνεύμονα. Το ICAM-1 και η Ε-σελεκτίνη θα μπορούσαννα χρησιμοποιηθούν ως πρόσθετοι προγνωστικοί παράγοντες. Το ICAM-1 ενδεχομένως ναέχει ρόλο προβλεπτικού δείκτη αντικειμενικής ανταπόκρισης.

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Small Cell Lung Cancer: Time To Diagnosis And Treatment

Cited by 6 publications

References 0 publications

Timely initiation of chemotherapy: a systematic literature review of six priority cancers – results and recommendations for clinical practice

Timely initiation of chemotherapy: a systematic literature review of six priority cancers – results and recommendations for clinical practice

Efficient solution of an inverse problem in cell population dynamics

H Προγνωστική Σημασία Των Κυκλοφορούντων Διαλυτών Μορίων Προσκόλλησης Σε Ασθενείς Με Μικροκυτταρικό Καρκίνο Πνεύμονα

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