Small cell carcinoma of the uterine cervix

Abstract

From 1962 to 1985, 2201 patients with invasive cervical cancer were staged, evaluated, and treated at the University of Kentucky Medical Center. After a thorough evaluation, 25 cases (1.1%) fulfilled the histologic criteria for small cell cancer defined by Reagan and coworkers. These patients were computer-matched for age, disease stage, and lesion size to 25 patients with large cell nonkeratinizing cancer and 25 patients with keratinizing squamous cell cancer. Morphometric analyses of nuclear size and maximum nuclear diameter were performed on all cases without knowledge of cell type. Small cell cancers were characterized by a nuclear area of 160 mu 2 or less and a maximum nuclear diameter of 16.2 mu, which was significantly lower than that for large cell tumors. Thirty-three percent of the small cell carcinomas stained positively for the neuroendocrine markers (neuron-specific enolase [NSE] and chromogranin [CGR]), whereas the remainder contained only epithelial markers such as cytokeratin (CYK) and epithelial membrane antigen (EMA). Small cell cancers were associated with a high frequency of lymph-vascular space invasion and a diminished lymphoplasmacytic response. Patients with small cell cancer had a significantly higher recurrence rate, particularly to extrapelvic sites, than the matched patients with large cell cancers, and their survival was lower. Clinical trials to determine the efficacy of adjuvant chemotherapy in the treatment of small cell cervical cancer are needed.

MRI of Small Cell Carcinoma of the Uterine Cervix with Pathologic Correlation

“…Small cell carcinoma of the uterine cervix is an aggressive tumor with early spread to the entire body, thereby leading to a fatal clinical course and minimal chance of survival [1][2][3][4]. Because of the distinct natural history of small cell carcinoma of the uterine cervix and because patients with this condition are considered to have a systemic disease, the treatment strategies for this disease are different from those of other carcinomas [4,5].…”

“…Accordingly, some patients may be inadequately treated because they are initially considered to have non-small cell carcinoma on the basis of Papanicolaou's smear result alone [4][5][6]. Therefore, the suggestion of small cell carcinoma on imaging studies is important for adequate patient treatment.…”

Granulocyte colony-stimulating factor-producing small-cell carcinoma of the uterine cervix: Report of a case

“…[1][2][3][4][5] Small-cell carcinoma of the uterine cervix is a very rare tumor, accounting for about 1% of all cervical carcinomas. 4,6 On cytodiagnosis of small-cell carcinoma, small round cells with a high N/C ratio, or lacking cytoplasm, are found to form dense clusters that are observed to be scattered on a necrotic background. Although it may be difficult to distinguish small-cell carcinoma of the cervix from squamouscell carcinoma of the small-cell nonkeratinizing type, the former tumor shows weaker cell linkage than the latter.…”

Differentiation of a Cell Line of Human Cervical Argyrophil Small Cell Carcinoma to Macrophage Lineage Cells

“…The clone that showed the most stable growth was used for the current study. Influence of dB-cAMP on cell proliferation of TC-YIK Adenosine dB-cAMP (Sigma, St. Louis, MO) was dissolved in distilled water at a concentration of 100 mM, 5 To whom requests for reprints should be addressed. …”

“…[1][2][3][4][5][6][7] Because ASCC is a rare cervical tumor, accounting for only 1.5 to 5% of all cervical tumors, [1][2][3][4][5][6][7] most reports on ASCC have been concerned with one or a few cases. Therefore, development of in vivo and in vitro experimental systems is desirable not only for examining the biological behavior of ASCC, but also for establishing an effective clinical treatment.…”