Small Cell Carcinoma of the Head and Neck: A Review

Renner, Gregory J.

doi:10.1053/j.seminoncol.2006.10.024

Cited by 130 publications

(166 citation statements)

References 103 publications

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“…Principally, other neuroendocrine neoplasms of the larynx such as typical and atypical carcinoid or large cell neuroendocrine carcinoma should be ruled out as they benefit from different prognosis 16 . Surgical procedures such as total laryngectomy, which cause a crucial decline in quality of life, are not advisable as a first treatment of choice, because laryngeal SCCNET is a lethal disease with a severely poor prognosis 17 .…”

Section: Discussionmentioning

confidence: 99%

Primary neuroendocrine small cell carcinoma in larynx: case report and literature review

Evsei

Iosif

Enache

et al. 2017

Romanian Journal of Rhinology

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Background. Neuroendocrine tumors of the larynx represent a rare group of neoplasms characterized by pathological and biological heterogeneity. The histological and immunohistochemical diagnosis is the most important step in the appropriate management of these tumors and the prognosis varies according to histological types. Conventional anatomical and functional imaging can be complementary for diagnosis, staging and monitoring of treatment response. Material and methods. Here we report on a case of a laryngeal neuroendocrine small cell carcinoma occurring in a 67-year-old man who was referred to our clinic for clinical reevaluation, diagnosis and treatment. The clinical presentation, the histopathological and immunohistochemical examination and management of this kind of tumor are highlighted. Conclusion. Small cell neuroendocrine carcinomas are very aggressive neoplasms. Patients could benefit from surgery, but radiotherapy and chemotherapy remain the treatment of choice. Very low incidence of neuroendocrine tumors in the larynx and specifically very poor prognosis of neuroendocrine small cell carcinoma encouraged an extensive literature review.

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Section: Discussionmentioning

confidence: 99%

Primary neuroendocrine small cell carcinoma in larynx: case report and literature review

Evsei

Iosif

Enache

et al. 2017

Romanian Journal of Rhinology

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“…[1,3,4] Distinction between SNEC and other neuroendocrine tumors, such as carcinoid tumors and an atypical carcinoid tumor is also of great importance because of its prognostic implication; SNEC being the most aggressive in this group. [1,5,6] Radiological imaging is imperative to certify loco-regional invasion, bone destruction and presurgical planning. [2] Magnetic resonance imaging (MRI) with T1 and T2 with gadolinium helps identify the tumoral relationship with surrounding structures and differentiate between inflammatory reactions and liquid retentions.…”

Section: Discussionmentioning

confidence: 99%

“…[1,5] Surgery usually followed by radiotherapy, or the combination of radio and chemotherapy are valid therapeutic options. [1,2,6] Our patient underwent endoscopic resection and adjuvant postoperative chemoradiotherapy. Global prognosis of SNEC is quite poor.…”

Section: Discussionmentioning

confidence: 99%

“…An epithelial origin deriving from mucoserous glands, associated with the existence of accessory ectopic salivary glands and a third hypothesis of a possible origin from basal cells in the olfactory mucosa. [2,6] Diagnosis of SNEC requires a typical neuroendocrine histological constitution and proper immunohistochemical recognition. [1,4] Histologically, it may be very similar to small-cell tumors of the lung, but clinically, it has an aggressive local behavior instead of early metastatic spread.…”

Section: Discussionmentioning

confidence: 99%

“…They include epistaxis, nasal obstruction and ophthalmologic signs such as proptosis. [3][4][5][6] Association with ectopic hormone syndrome has been described for SNEC and has a negative influence on prognosis as it does in pulmonary small cell carcinomas. [1,5] Surgery usually followed by radiotherapy, or the combination of radio and chemotherapy are valid therapeutic options.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Small-cell neuroendocrine carcinoma of the nasal septum: unusual location for a known type of neoplasm

Villarreal

Arellano

Pinilla

et al. 2016

Acta Oto-Laryngologica Case Reports

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Small-cell neuroendocrine carcinoma (SNEC) is a distinct tumoral entity characterized by rapid local invasion, widespread dissemination and a poor prognosis. Due to its late discovery, localization is rarely precise. We report a case of a 39-year-old man whose clinical symptoms, radiological findings histological diagnosis and immunohistochemical staining confirm a primary SNEC of the nasal septum. Clinical features of nasal SNEC are nonspecific, including those resembling benign lesions; hence, it is likely to result in a delay in its discovery and treatment. Distinction between SNEC and other neuroendocrine tumors is also of great importance because of its prognostic implication, being SNEC the most aggressive in this group. Surgery, radiotherapy and chemotherapy alone or in combination have been used for these patients. Unfortunately, due to the rarity of this neoplasm, there is no specific recommendation on management guidelines, and treatment possibilities should be individualized for each patient.ARTICLE HISTORY

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Pathology Quiz Case 1: Diagnosis

2012

Arch Otolaryngol Head Neck Surg

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Small Cell Carcinoma of the Head and Neck: A Review

Cited by 130 publications

References 103 publications

Primary neuroendocrine small cell carcinoma in larynx: case report and literature review

Primary neuroendocrine small cell carcinoma in larynx: case report and literature review

Small-cell neuroendocrine carcinoma of the nasal septum: unusual location for a known type of neoplasm

Pathology Quiz Case 1: Diagnosis

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