Small cell carcinoma of the salivary gland: a systematic literature review and two case reports

Servato, João Paulo Silva; Silva, S.J. da; Faria, Paulo Rogério de; Cardoso, Sérgio Vitorino; Loyola, A.M.

doi:10.1016/j.ijom.2012.10.004

Cited by 26 publications

(43 citation statements)

References 48 publications

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“…To this regard, our results are in keeping with those described by other authors [18,[36][37][38][39][40][41]. Although Shield et al [18] represent the most extensive work of MCC on FNC, the immunocytochemistry of this study employed only three neuroendocrine markers (CD56, synaptophysin, and chromogranin), compared to our four, and it was carried out on cell block samples associated with flow cytometry, two rather expensive techniques compared to the use of simple smears.…”

Section: Discussionsupporting

confidence: 87%

Cytological and Immunocytochemical Features of Merkel Cell Carcinoma on Fine Needle Cytology Samples: A Study of 22 Cases

et al. 2015

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Merkel cell carcinoma (MCC) is an uncommon neuroendocrine small cell tumor derived from the transformation of the homonymous cells in the basal layer of the epidermis. MCC has a generally aggressive course, with a high tendency for local recurrence, lymph node involvement, and distant metastasis. Fine needle cytology (FNC) and immunocytochemistry were used as diagnostic procedures for 22 cases of MCC presented at our institute. All cases of MCC were successfully diagnosed on FNC. Among all of the monoclonal antisera used (CD56, CK20, CK MNF116, neuron-specific enolase (NSE), synaptophysin, and chromogranin), NSE and CD56 showed the highest frequency of positivity. The accuracy of the cytological diagnosis was 100% compared to the corresponding previous or subsequent pathological diagnoses. FNC and immunocytochemistry represent excellent and accurate diagnostic methods to distinguish MCC from other small-cell malignant entities.

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Section: Discussionsupporting

confidence: 87%

Cytological and Immunocytochemical Features of Merkel Cell Carcinoma on Fine Needle Cytology Samples: A Study of 22 Cases

et al. 2015

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“…With 344 cases, we conducted the largest study to date of parotid SmCC and reviewed its clinical features and predictors of survival. Salivary gland SmCC represents <1% of all major salivary gland cancers, and most frequently involves the parotid gland (80%) …”

Section: Discussionmentioning

confidence: 99%

“…Salivary gland small cell carcinoma (SmCC) is extraordinarily rare, comprising 1.1% of major salivary gland malignancies and <1% of primary parotid malignancies . Approximately 80% of major salivary SmCCs arise in the parotid gland . Literature on parotid SmCC consists primarily of case reports or small case series that report conflicting results regarding clinical and survival features .…”

Section: Introductionmentioning

confidence: 99%

Predictors of survival in parotid small cell carcinoma: A study of 344 cases

et al. 2016

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“…Given the rarity of this tumor, there is a paucity of clinical outcomes data available to guide treatment recommendations. A previous analysis has reported the outcomes of salivary gland small cell carcinomas [5, 6]; however, there is limited data on non-salivary gland head and neck small cell carcinomas. We performed an analysis of the National Cancer Database and report on the largest series of non-salivary gland, non-thyroid head and neck tumors classified as either small cell carcinoma or poorly differentiated neuroendocrine tumors.…”

Section: Introductionmentioning

confidence: 99%

Small cell carcinoma of the head and neck: An analysis of the National Cancer Database

et al. 2017

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Purpose/Objective(s) To evaluate treatment trends and overall survival of patients with small cell carcinoma of the head and neck region. Materials/Methods Patients from 2004–2012 were identified from the National Cancer Database. Patient demographics and overall survival were analyzed. Multivariable analysis was used to identify predictors of survival. Results Among 347,252 head and neck patients a total of 1,042 (0.3%) patients with small cell carcinoma were identified. 17% of patients were diagnosed as stage I/II, 61% as stage III/IVA/IVB and 22% as stage IVC disease. The distribution by anatomic site was 9% oral cavity, 12% oropharynx, 35% larynx, 4% hypopharynx, 10% nasopharynx and 30% nasal cavity and paranasal sinuses. The median overall survival by anatomical site was 20.8 months for oral cavity, 23.7 months for oropharynx, 17.9 months for larynx/hypopharynx, 15.1 months for nasopharynx and 36.4 months for nasal cavity primary tumors. On multivariable analysis across stage, patients with nasal cavity and paranasal sinuses tumors had the best survival and patients with nasopharynx primaries had the worst survival. In stage I/II patients, type of treatment delivered resulted in no overall survival difference (p=0.78). In patients with locally advanced disease, there was no difference in survival between those treated with combined surgery, radiotherapy and chemotherapy compared to those treated only with radiotherapy and chemotherapy (p=0.46). The addition of radiotherapy to chemotherapy in the metastatic setting did not result in improved survival (p=0.14). Conclusions Small cell carcinoma of the head and neck is a rare malignancy with a poor prognosis. The addition of surgery to radiotherapy and chemotherapy did not improve survival in patients with locally advanced disease.

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Small cell carcinoma of the salivary gland: a systematic literature review and two case reports

Cited by 26 publications

References 48 publications

Cytological and Immunocytochemical Features of Merkel Cell Carcinoma on Fine Needle Cytology Samples: A Study of 22 Cases

Cytological and Immunocytochemical Features of Merkel Cell Carcinoma on Fine Needle Cytology Samples: A Study of 22 Cases

Predictors of survival in parotid small cell carcinoma: A study of 344 cases

Small cell carcinoma of the head and neck: An analysis of the National Cancer Database

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