Predictors of survival in parotid small cell carcinoma: A study of 344 cases

Abstract

4 Laryngoscope, 126:2036-2040, 2016.

Small Cell Neuroendocrine Carcinoma of the Parotid Gland: A Chronicle of Publications Based on the Largest Case Series and a Report of the First Greek Case

“…The incidence of regional lymph node metastasis is around 50.8% and adding the occult lymph node metastasis sums up at 65.1%. This is the reason why neck dissection is necessary in the treatment of SCCs [2]. All of these demographics are in accordance with previous case series [8,9].…”

“…What is not in accordance is the distant metastasis rate, where Zhan, et al state distant metastases to be found in 7.3% of all cases. This is explained because it refers in the initial staging of patients [2]. During the course of the disease this figure climbs up to 45% [8,9,11].…”

“…During the course of the disease this figure climbs up to 45% [8,9,11]. Zhan, et al report that five and 10year survival rate is 37% and 20% respectively, and median survival is 28.5 months [2], Servato, et al similarly reports 5-year OS at 36.6% [9], whereas Nagao, et al found 5 year OS to be worse at 13% and median survival 15.9 months [8].…”

“…SCCs usually arise in the lungs but 2-4% are extrapulmonary cases [1]. In the salivary glands they are extremely rare consisting < 1% of major salivary glands malignancies and 1% of primary parotid malignancies [2]. Due to this rarity, extended research has not been conducted yet to facilitate treatment guidance and our knowledge is based on case reports and case series [3].…”

Small cell carcinoma of the head and neck: An analysis of the National Cancer Database

“…Given the rarity of this tumor, there is a paucity of clinical outcomes data available to guide treatment recommendations. A previous analysis has reported the outcomes of salivary gland small cell carcinomas [5, 6]; however, there is limited data on non-salivary gland head and neck small cell carcinomas. We performed an analysis of the National Cancer Database and report on the largest series of non-salivary gland, non-thyroid head and neck tumors classified as either small cell carcinoma or poorly differentiated neuroendocrine tumors.…”