Avalonian-Cadomian and related terranes of the circum-North Atlantic constitute portions of an accretionary orogen that developed on an active Gondwanan margin at the periphery of the Neoproterozoic supercontinent Vendia. As a peripheral orogenic belt lying oblique to adjacent cratonic age provinces and the interior collisional orogenic sutures associated with supercontinent assembly, its component terranes are likely to have evolved upon different cratonic basements. Available Nd isotopic data and U-Pb detrital zircon ages support this contention and suggest that West Avalonia, Carolina, and Florida lay adjacent to the Amazonian craton during the Neoproterozoic, whereas Cadomia, Spain, and portions of East Avalonia occupied positions adjacent to the West African craton.Neodymium isotopic compositions for crustally derived felsic rocks from each of these peri-Gondwanan terranes are typical of the upper crust (Sm/Nd ≈ 0.19). However, initial ε Nd values for West Avalonia are strongly positive with 1.1-0.8 Ga depleted mantle model ages, whereas those for Cadomia are predominantly negative and yield crustal residence ages of 1.9-1.0 Ga. Nd evolution diagrams for West Avalonia show little overlap with those for Cadomia (suggesting basements of contrasting isotopic characteristics) but closely match those of the Tocantins Province that borders the Amazonian craton in Central Brazil. A peri-Amazonian position for West Avalonia is also suggested by detrital zircon data from Neoproterozoic metasedimentary units that match all age provinces of the Amazonian craton. By contrast, Nd isotopic data for Cadomian basement (ca. 2.0 Ga Icart Gneiss) closely resemble those for 2.1-2.0 Ga (Eburnian) granitoids in West Africa. Basement of similar isotopic characteristics to that of Cadomia also provided the source for Cambrian sedimentary rocks in the Meguma terrane that contain detrital zircons that match each of the age provinces of the West African craton. East Avalonia shows Nd isotopic affinities with both West Avalonia and Cadomia and may straddle a suture between their respective basements. Zircon ages and Nd isotopic data for Carolina and the Florida subsurface (Suwannee terrane) also show similarities with those for West Avalonia but suggest a more evolved crustal component of possible Grenville age, supporting their derivation from more westerly present-day peri-Amazonian positions.Such variations in basement isotopic signatures provide important constraints for Neoproterozoic paleogeographic reconstruction of the now-dismembered AvalonianCadomian orogenic belt and may be of more general application to the palinspastic restoration of dispersed Precambrian terranes.