SLS/βCD-curcumin nanosuspension: Preparation, characterization and pharmacological evaluation

Moorthi, C.; Kumar, Chiranjeev; Mohan, S.; Kathiresan, K.

doi:10.1016/j.jopr.2013.04.002

Cited by 7 publications

(6 citation statements)

References 7 publications

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“…As explained, the main purpose of developing curcumin nanoformulations is to enhance its solubility, thus avoiding its fast metabolism at intestinal level, and ultimately increasing its bioavailability and its cell uptake (Dei Cas & Ghidoni, 2019; Moorthi, Senthil Kumar, Mohan, & Kathiresan, 2013). Various animal studies have carefully addressed curcumin nanoformulations accuracy and safety and have concluded that this is associated with its loading and release (example in Figure 2) (Dei Cas & Ghidoni, 2019; Ravichandran, 2013).…”

Section: Pharmacological Properties Of Curcumin Nanoformulationsmentioning

confidence: 99%

Curcumin nanoformulations for antimicrobial and wound healing purposes

Salehi

Rodrigues

Peron

et al. 2021

Phytotherapy Research

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The development and spread of resistance to antimicrobial drugs is hampering the management of microbial infectious and wound healing processes. Curcumin is the most active and effective constituent of Curcuma longa L., also known as turmeric, and has a very long and strong history of medicinal value for human health and skincare. Curcumin has been proposed as strong antimicrobial potentialities and many attempts have been made to determine its ability to conjointly control bacterial growth and promote wound healing. However, low aqueous solubility, poor tissue absorption and short plasma half‐life due its rapid metabolism needs to be solved for made curcumin formulations as suitable treatment for wound healing. New curcumin nanoformulations have been designed to solve the low bioavailability problem of curcumin. Thus, in the present review, the therapeutic applications of curcumin nanoformulations for antimicrobial and wound healing purposes is described.

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Section: Pharmacological Properties Of Curcumin Nanoformulationsmentioning

confidence: 99%

Curcumin nanoformulations for antimicrobial and wound healing purposes

Salehi

Rodrigues

Peron

et al. 2021

Phytotherapy Research

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“…Collectively, prepared SLS/βCD-CUR nanosuspension through the decrement in size of CUR, enhancing its aqueous stability, reactability, and solubility of CUR increased its medical efficacy in wound treatment. 142 Thomas et al 143 provided several nanoemulsions composed of Labrafac PG + Triacetin, Tween 80, and PEG 400. They selected CUR entrapped nanoemulsion gel (NEG) and evaluated its wound healing effect in Albino rats that suffered from incision back wound model.…”

Section: Type Of Nanoparticlementioning

confidence: 99%

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

et al. 2023

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Despite numerous advantages, curcumin's (CUR) low solubility and low bioavailability limit its employment as a free drug. CUR‐incorporated nanoformulation enhances the bioavailability and angiogenesis, collagen deposition, fibroblast proliferation, reepithelization, collagen synthesis, neovascularization, and granulation tissue formation in different wounds. Designing nanoformulations with controlled‐release properties ensure the presence of CUR in the defective area during treatment. Different nanoformulations encompassing nanofibers, nanoparticles (NPs), nanospray, nanoemulsion, nanosuspension, nanoliposome, nanovesicle, and nanomicelle were described in the present study comprehensively. Moreover, for some other systems which contain nano‐CUR or CUR nanoformulations, including some nanofibers, films, composites, scaffolds, gel, and hydrogels seems the CUR‐loaded NPs incorporation has better control of the sustained release, and thereby, the presence of CUR until the final stages of wound healing is more possible. Incorporating CUR‐loaded chitosan NPs into nanofiber increased the release time, while 80% of CUR was released during 240 h (10 days). Therefore, this system can guarantee the presence of CUR during the entire healing period. Furthermore, porous structures such as sponges, aerogels, some hydrogels, and scaffolds disclosed promising performance. These architectures with interconnected pores can mimic the native extracellular matrix, thereby facilitating attachment and infiltration of cells at the wound site, besides maintaining a free flow of nutrients and oxygen within the three‐dimensional structure essential for rapid and proper wound healing, as well as enhancing mechanical strength.

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“…Eudragit E 100 nanoparticles were prepared by nanoprecipitation technique [17][18][19] with slight modification. Briefly, polymer was dissolved in organic solvent, which was transferred in to distilled water under sonication (40 kHz, Lark, India).…”

Section: Fabrication Of Eudragit E 100 Nanoparticles By Modified Nanomentioning

confidence: 99%

A Step-by-Step Optimization Process to Fabricate Narrow Sized Dual Drug Loaded Polymeric Nanoparticles Using Modified Nanoprecipitation Technique

Chidambaram¹,

Krishnasamy²

2013

Nano BioMed ENG

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The primary aim of the study was to prepare narrow sized polymeric nanoparticles by implementing few modifications to the conventional nanoprecipitation technique and to evaluate the effect of various process parameters on prepared polymeric nanoparticles. Eudragit E 100 nanoparticles were prepared by modified nanoprecipitation technique and step-by-step optimization was carried out to evaluate the effect of various process parameters such as organic solvent, polymer concentration, percentage of organic solvent, mode of addition of organic solvent in to aqueous phase, volume of aqueous phase, poloxamer 188 concentration, β-cyclodextrin concentration, temperature generated during sonication process, sonication duration, and drug concentration on the particle size, surface area, distribution width and uniformity of the prepared nanoparticles. The optimized process parameters were implemented to fabricate dual drug loaded Eudragit E 100 nanoparticles which were spherical in shape with mean particle size in the range of 118 to 140 nm, polydispersity index in the range of 0.187 to 0.254 and zeta potential in the range of 16.6 to 28.8 mV. Thus developed modified nanoprecipitation method can be used to fabricate narrow sized polymeric nanoparticles.

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SLS/βCD-curcumin nanosuspension: Preparation, characterization and pharmacological evaluation

Cited by 7 publications

References 7 publications

Curcumin nanoformulations for antimicrobial and wound healing purposes

Curcumin nanoformulations for antimicrobial and wound healing purposes

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

A Step-by-Step Optimization Process to Fabricate Narrow Sized Dual Drug Loaded Polymeric Nanoparticles Using Modified Nanoprecipitation Technique

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