Slower V˙O2 Kinetics in Older Individuals

Murias, Juan M.; Paterson, Donald H.

doi:10.1249/mss.0000000000000686

Cited by 21 publications

(16 citation statements)

References 79 publications

(138 reference statements)

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“…V O 2 pulm kinetics, used as a proxy of V O 2 musc kinetics, seem to be slower in aged compared with younger subjects [2][3][4]11] (off kinetics only), [17,18,41,42], but depend on physical activity [2, 12 − 14, 25, 44]. The limitation of V O 2 kinetics in aged subjects can be ascribed to several mechanisms, which can be classified into either O 2 delivery and/or O 2 extraction, either centrally or peripherally mediated [24,38,39]. The O 2 extraction depends on the complex interplay between availability of O 2 at the mitochondria, adequate activation of enzymes, supply of substrates for oxidative phosphorylation and ATP synthesis in the working muscle cell [16].…”

Section: Abstract ▼mentioning

confidence: 99%

“…Slowed HR kinetics are one possible limiting factor for O 2 delivery and may explain slowed V O 2 pulm kinetics [13,16,17] though only if the arteriovenous oxygen difference (avDO 2 ) is not sufficient to compensate for slowed HR kinetics [7]. The limiting factors of V O 2 kinetics are under discussion [16,21,28,29,38,43]. A differential analysis of cardiorespiratory kinetics should be performed for the detection of individual limitation of V O 2 kinetics.…”

Section: Abstract ▼mentioning

confidence: 99%

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Muscular Oxygen Uptake Kinetics in Aged Adults

et al. 2016

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Pulmonary oxygen uptake (V˙O2) kinetics and heart rate kinetics are influenced by age and fitness. Muscular V˙O2 kinetics can be estimated from heart rate and pulmonary V˙O2. In this study the applicability of a test using pseudo-random binary sequences in combination with a model to estimate muscular V˙O2 kinetics was tested. Muscular V˙O2 kinetics were expected to be faster than pulmonary V˙O2 kinetics, slowed in aged subjects and correlated with maximum V˙O2 and heart rate kinetics. 27 elderly subjects (73±3 years; 81.1±8.2 kg; 175±4.7 cm) participated. Cardiorespiratory kinetics were assessed using the maximum of cross-correlation functions, higher maxima implying faster kinetics. Muscular V˙O2 kinetics were faster than pulmonary V˙O2 kinetics (0.31±0.1 vs. 0.29±0.1 s; p=0.004). Heart rate kinetics were not correlated with muscular or pulmonary V˙O2 kinetics or maximum V˙O2. Muscular V˙O2 kinetics correlated with maximum V˙O2 (r=0.35; p=0.033). This suggests, that muscular V˙O2 kinetics are faster than estimates from pulmonary V˙O2 and related to maximum V˙O2 in aged subjects. In the future this experimental approach may help to characterize alterations in muscular V˙O2 under various conditions independent of motivation and maximal effort.

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Section: Abstract ▼mentioning

confidence: 99%

Section: Abstract ▼mentioning

confidence: 99%

Muscular Oxygen Uptake Kinetics in Aged Adults

et al. 2016

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“…Aging is accompanied by the development of chronic diseases, which makes it necessary to give greater attention to the elderly population [2]. Maximal oxygen consumption (VO 2max ) is recognized as one of the most important indicators in the prognosis of good health in older people [3] and it is used to predict survival in patients with cardiovascular disease [4][5][6][7][8]. A decrease in VO 2max is one of the clearest consequences of aging since, from the age of 30, it decreases by 10% every 10 years in people with a sedentary lifestyle [9].…”

Section: Introductionmentioning

confidence: 99%

High-Intensity Interval Circuit Training Versus Moderate-Intensity Continuous Training on Cardiorespiratory Fitness in Middle-Aged and Older Women: A Randomized Controlled Trial

Ballesta-García

González-Moro

Ramos-Campo

et al. 2020

IJERPH

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High-intensity interval training (HIIT) has similar or better effects than moderate-intensity continuous training (MICT) in increasing peak oxygen consumption (VO2max), however, it has not been studied when HIIT is applied in a circuit (HIICT). The aim of this study was to compare the effects of a HIICT versus MICT on VO2max estimated (VO2max-ES), heart rate (HR) and blood pressure (BP) of middle-aged and older women. A quasi-experimental randomized controlled trial was used. Fifty-four women (67.8 ± 6.2 years) were randomized to either HIICT (n = 18), MICT (n = 18) or non-exercise control group (CG; n = 18) for 18 weeks. Participants in HIICT and MICT trained two days/week (one hour/session). Forty-one participants were assessed (HIICT; n = 17, MICT; n = 12, CG; n = 12). Five adverse events were reported. Cardiorespiratory fitness, HR and BP were measured. The tests were performed before and after the exercise intervention programs. VO2max-ES showed significant training x group interaction, in which HIICT and MICT were statistically superior to CG. Moreover, HIICT and MICT were statistically better than CG in the diastolic blood pressure after exercise (DBPex) interaction. For the systolic blood pressure after exercise (SBPex), HIICT was statistically better than CG. In conclusion, both HIICT and MICT generated adaptations in VO2max-ES and DBPex. Furthermore, only HIICT generated positive effects on the SBPex. Therefore, both training methods can be considered for use in exercise programs involving middle-aged and older women.

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“…Studies assessing the

O 2 kinetics response in young and older adults have regularly shown slower τ

O 2 values in the aging population (Chilibeck et al, 1996 ; DeLorey et al, 2004 ; Murias et al, 2010 ; Gravelle et al, 2012 ). Although debate exists in relation to the mechanisms that control the rate of adjustment of oxidative phosphorylation (Grassi, 2001 ; Hughson et al, 2001 ; Poole and Jones, 2012 ; Murias et al, 2014 ; Murias and Paterson, 2015 ), there is a stronger consensus supporting the idea that, in older populations, the slower dynamic adjustment of

O 2 is related to limitations within the O 2 transport system and, more specifically, in the O 2 provision to the active muscles which affects the matching of O 2 delivery to O 2 utilization (Murias et al, 2010 ; Poole and Jones, 2012 ). However, a slower adjustment of oxidative phosphorylation in older individuals is not always the case.…”

Section: Discussionmentioning

confidence: 99%

Fitness Level and Not Aging per se, Determines the Oxygen Uptake Kinetics Response

et al. 2018

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Although aging has been associated to slower trueV˙O2 kinetics, some evidence indicates that fitness status and not aging per se might modulate this response. The main goal of this study was to examine the trueV˙O2, deoxygenated hemoglobin+myoglobin (deoxy-[Hb+Mb]) kinetics, and the NIRS-derived vascular reperfusion responses in older compared to young men of different training levels (i.e., inactive, recreationally active, and endurance trained). Ten young inactive [YI; 26 ± 5 yrs.; peak trueV˙O2 (trueV˙O2peak), 2.96 ± 0.55 L·min−1], 10 young recreationally active (YR; 26 ± 6 yrs.; 3.92 ± 0.33 L·min−1), 10 young endurance trained (YT; 30 ± 4 yrs.; 4.42 ± 0.32 L·min−1), 7 older inactive (OI; 69 ± 4 yrs.; 2.50 ± 0.31 L·min−1), 10 older recreationally active (OR; 69 ± 5 yrs.; 2.71 ± 0.42 L·min−1), and 10 older endurance trained (OT; 66 ± 3 yrs.; 3.20 ± 0.35 L·min−1) men completed transitions of moderate intensity cycling exercise (MODS) to determine trueV˙O2 and deoxy-[Hb+Mb] kinetics, and the deoxy-[Hb+Mb]/trueV˙O2 ratio. The time constant of trueV˙O2 (τtrueV˙O2) was greater in YI (38.8 ± 10.4 s) and OI (44.1 ± 10.8 s) compared with YR (26.8 ± 7.5 s) and OR (26.6 ± 6.5 s), as well as compared to YT (14.8 ± 3.4 s), and OT (17.7 ± 2.7 s) (p < 0.05). τtrueV˙O2 was greater in YR and OR compared with YT and OT (p < 0.05). The deoxy-[Hb+Mb]/trueV˙O2 ratio was greater in YI (1.23 ± 0.05) and OI (1.29 ± 0.08) compared with YR (1.11 ± 0.03) and OR (1.13 ± 0.06), as well as compared to YT (1.01 ± 0.03), and OT (1.06 ± 0.03) (p < 0.05). Similarly, the deoxy-[Hb+Mb]/ trueV˙O2 ratio was greater in YR and OR compared with YT and OT (p < 0.05). There was a main effect of training (p = 0.033), whereby inactive (p = 0.018) and recreationally active men (p = 0.031) had significantly poorer vascular reperfusion than endurance trained men regardless of age. This study demonstrated not only that age-related slowing of trueV˙O2 kinetics can be eliminated in endurance trained individuals, but also that inactive lifestyle negatively impacts the trueV˙O2 kinetics response of young healthy individuals.

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Slower V˙O2 Kinetics in Older Individuals

Abstract: Thus, this review focuses on the concept that although V̇O₂ kinetics is often slower in the elderly, this slower increase in the rise of oxygen uptake during the exercise on-transient does not need to be considered an inevitable response.

Cited by 21 publications

References 79 publications

Muscular Oxygen Uptake Kinetics in Aged Adults

Muscular Oxygen Uptake Kinetics in Aged Adults

High-Intensity Interval Circuit Training Versus Moderate-Intensity Continuous Training on Cardiorespiratory Fitness in Middle-Aged and Older Women: A Randomized Controlled Trial

Fitness Level and Not Aging per se, Determines the Oxygen Uptake Kinetics Response

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