Muscular Oxygen Uptake Kinetics in Aged Adults

Koschate, Jessica; Drescher, Uwe; Baum, K; Eichberg, Sabine; Schiffer, Thorsten; Latsch, Joachim; Brixius, Klara; Hoffmann, Uwe

doi:10.1055/s-0042-101413

Cited by 6 publications

(3 citation statements)

References 33 publications

(79 reference statements)

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“…For comparison, HR kinetics have been shown to be faster than V'O 2 musc kinetics in healthy young subjects [14,28]. In sedentary aged subjects, V'O 2 musc kinetics were faster (but not significantly) than HR kinetics [29]. This is in line with the results of the T2D p and T2D group, in the present study.…”

Section: Discussionsupporting

confidence: 91%

Heart Rate and Oxygen Uptake Kinetics in Type 2 Diabetes Patients – A Pilot Study on the Influence of Cardiovascular Medication on Regulatory Processes

Koschate

Drescher

Baum

et al. 2017

Exp Clin Endocrinol Diabetes

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The aim of this pilot study was to investigate whether there are differences in heart rate and oxygen uptake kinetics in type 2 diabetes patients, considering their cardiovascular medication. It was hypothesized that cardiovascular medication would affect heart rate and oxygen uptake kinetics and that this could be detected using a standardized exercise test. 18 subjects were tested for maximal oxygen uptake. Kinetics were measured in a single test session with standardized, randomized moderate-intensity work rate changes. Time series analysis was used to estimate kinetics. Greater maxima in cross-correlation functions indicate faster kinetics. 6 patients did not take any cardiovascular medication, 6 subjects took peripherally acting medication and 6 patients were treated with centrally acting medication. Maximum oxygen uptake was not significantly different between groups. Significant main effects were identified regarding differences in muscular oxygen uptake kinetics and heart rate kinetics. Muscular oxygen uptake kinetics were significantly faster than heart rate kinetics in the group with no cardiovascular medication (maximum in cross-correlation function of muscular oxygen uptake vs. heart rate; 0.32±0.08 vs. 0.25±0.06; p=0.001) and in the group taking peripherally acting medication (0.34±0.05 vs. 0.28±0.05; p=0.009) but not in the patients taking centrally acting medication (0.28±0.05 vs. 0.30±0.07; n.s.). It can be concluded that regulatory processes for the achievement of a similar maximal oxygen uptake are different between the groups. The used standardized test provided plausible results for heart rate and oxygen uptake kinetics in a single measurement session in this patient group.

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Section: Discussionsupporting

confidence: 91%

Heart Rate and Oxygen Uptake Kinetics in Type 2 Diabetes Patients – A Pilot Study on the Influence of Cardiovascular Medication on Regulatory Processes

Koschate

Drescher

Baum

et al. 2017

Exp Clin Endocrinol Diabetes

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“…Other modifications were already shown by applications with other modes of exercise, e.g. treadmill (Koschate et al 2016a , b ) or arm cranking exercise (Drescher et al 2015 ). With a certain loss of reliability, the PRBS could be shortened, e.g.…”

Section: Limitationsmentioning

confidence: 98%

“…In terms of control technology, the CRP responses to exercise can be described as a single-input/single-output system (i. e. WR-CRP). The description of these systems allows to identify the influence of factors such as type of exercise (Koschate et al 2019a , b ), ambient conditions (Drescher et al 2018 ) and individual characteristics, e. g. age (Koschate et al 2016a , b ; Ebine et al 2018 ; Patti et al 2021 ) or fitness (Beltrame et al 2020 ; Inglis et al 2021 ), on the regulation of the cardiorespiratory system. From the individual kinetics and other characteristics of regulation, interventions, e. g. exercise prescriptions for athletes and patients, can be defined.…”

Section: Introductionmentioning

confidence: 99%

Cardiorespiratory kinetics in exercise physiology: estimates and predictions using randomized changes in work rate

et al. 2021

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Purpose Kinetics of cardiorespiratory parameters (CRP) in response to work rate (WR) changes are evaluated by pseudo-random binary sequences (PRBS testing). In this study, two algorithms were applied to convert responses from PRBS testing into appropriate impulse responses to predict steady states values and responses to incremental increases in exercise intensity. Methods 13 individuals (age: 41 ± 9 years, BMI: 23.8 ± 3.7 kg m−2), completing an exercise test protocol, comprising a section of randomized changes of 30 W and 80 W (PRBS), two phases of constant WR at 30 W and 80 W and incremental WR until subjective fatigue, were included in the analysis. Ventilation ($$\dot{V}_{{\text{E}}}$$ V ˙ E ), O2 uptake ($$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 ), CO2 output ($$\dot{V}{\text{CO}}_{2}$$ V ˙ CO 2 ) and heart rate (HR) were monitored. Impulse responses were calculated in the time domain and in the frequency domain from the cross-correlations of WR and the respective CRP. Results The algorithm in the time domain allows better prediction for $$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 and $$\dot{V}{\text{CO}}_{2}$$ V ˙ CO 2 , whereas for $$\dot{V}_{{\text{E}}}$$ V ˙ E and HR the results were similar for both algorithms. Best predictions were found for $$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 and HR with higher (3–4%) 30 W steady states and lower (1–4%) values for 80 W. Tendencies were found in the residuals between predicted and measured data. Conclusion The CRP kinetics, resulting from PRBS testing, are qualified to assess steady states within the applied WR range. Below the ventilatory threshold, $$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 and HR responses to incrementally increasing exercise intensities can be sufficiently predicted.

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Gas exchange kinetics following concentric-eccentric isokinetic arm and leg exercise

Drescher

Mookerjee

Steegmanns

et al. 2017

Respiratory Physiology & Neurobiology

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Muscular Oxygen Uptake Kinetics in Aged Adults

Cited by 6 publications

References 33 publications

Heart Rate and Oxygen Uptake Kinetics in Type 2 Diabetes Patients – A Pilot Study on the Influence of Cardiovascular Medication on Regulatory Processes

Heart Rate and Oxygen Uptake Kinetics in Type 2 Diabetes Patients – A Pilot Study on the Influence of Cardiovascular Medication on Regulatory Processes

Cardiorespiratory kinetics in exercise physiology: estimates and predictions using randomized changes in work rate

Gas exchange kinetics following concentric-eccentric isokinetic arm and leg exercise

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