Slow Oscillations (≤1 Hz) Mediated by GABAergic Interneuronal Networks in Rat Hippocampus

Zhang, Y.; Velázquez, José Luis Pérez; Tian, Guo Feng; Wu, Chenggang; Skinner, Frances K.; Carlen, Peter L.; Zhang, L.

doi:10.1523/jneurosci.18-22-09256.1998

Cited by 87 publications

(68 citation statements)

References 78 publications

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“…Previously, GABAergic interneurons had been shown to inhibit themselves or other GABAergic neurons to promote disinhibition [6]. This study complements the previous studies by providing interesting findings of a slow oscillation in CA1 principal cells and interneurons mediated by GABA A receptors [7]. This work reveals important aspects of the interneuron circuit for generating slow oscillations and provides insights for understanding GABAergic transmission in hippocampal networks.…”

supporting

confidence: 78%

Harnessing GABAergic Transmission for Slow Oscillations

Zhan

2016

Neurosci. Bull.

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supporting

confidence: 78%

Harnessing GABAergic Transmission for Slow Oscillations

Zhan

2016

Neurosci. Bull.

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“…The non-selective K IR antagonist Cs + induces the appearance of epileptiform activity in the CA1 area of hippocampal slices, suggesting that K IR plays a crucial role in controlling resting excitability in the hippocampus (Zhang et al, 1998;Andreasen et al, 2007). Here, we have shown that concentrations of Ba 2+ that selectively block K IR (Kubo et al, 1993;Schoots et al, 1996) without affecting K M (Cloues and Marrion, 1996) can trigger spontaneous interictal-like events in the EC.…”

Section: Involvement Of K Ir In the Generation And Maintenance Of Cchmentioning

confidence: 65%

Involvement of inward rectifier and M-type currents in carbachol-induced epileptiform synchronization

et al. 2011

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Exposure to cholinergic agonists is a widely used paradigm to induce epileptogenesis in vivo and synchronous activity in brain slices maintained in vitro. However, the mechanisms underlying these effects remain unclear. Here, we used field potential recordings from the lateral entorhinal cortex in horizontal rat brain slices to explore whether two different K + currents regulated by muscarinic receptor activation, the inward rectifier (K IR ) and the M-type (K M ) currents, have a role in carbachol (CCh)-induced field activity, a prototypical model of cholinergic-dependent epileptiform synchronization. To establish whether K IR or K M blockade could replicate CCh effects, we exposed slices to blockers of these currents in the absence of CCh. K IR channel blockade with micromolar Ba 2+ concentrations induced interictal-like events with duration and frequency that were lower than those observed with CCh; by contrast, the K M blocker linopirdine was ineffective. Pre-treatment with Ba 2+ or linopirdine increased the duration of epileptiform discharges induced by subsequent application of CCh. Baclofen, a GABA B receptor agonist that activates K IR , abolished CCh-induced field oscillations, an effect that was abrogated by the GABA B receptor antagonist CGP 55845, and prevented by Ba 2+ . Finally, when applied after CCh, the K M activators flupirtine and retigabine shifted leftward the cumulative distribution of CChinduced event duration; this effect was opposite to what seen during linopirdine application under similar experimental conditions. Overall, our findings suggest that K IR rather than K M plays a major regulatory role in controlling CCh-induced epileptiform synchronization.

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“…In deep non-REM sleep, which is prominent in conditions of high sleep propensity such as after sleep deprivation, the EEG slow oscillation Ͻ1 Hz is the main source of ␦ activity (Amzica and Steriade, 1998;Massimini et al, 2004). It is interesting to note that the generation of the slow oscillation in rat hippocampal brain slices was shown to require an adenosinedependent inhibition of glutamatergic transmission (Zhang et al, 1998). Nevertheless, it should be considered that our method reflects EEG power and not necessarily the slow oscillation in non-REM sleep.…”

Section: Discussionmentioning

confidence: 99%

Adenosinergic Mechanisms Contribute to Individual Differences in Sleep Deprivation-Induced Changes in Neurobehavioral Function and Brain Rhythmic Activity

Rétey¹,

Adam²,

Gottselig³

et al. 2006

J. Neurosci.

109

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Large individual differences characterize the changes induced by sleep deprivation on neurobehavioral functions and rhythmic brain activity. To investigate adenosinergic mechanisms in these differences, we studied the effects of prolonged waking and the adenosine receptor antagonist caffeine on sustained vigilant attention and regional electroencephalogram (EEG) power in the ranges of theta activity (6.25-8.25 Hz) in waking and the slow oscillation (Ͻ1 Hz) in sleep. Activity in these frequencies is functionally related to sleep deprivation. In 12 subjectively caffeine-sensitive and 10 -insensitive young men, psychomotor vigilance task (PVT) performance and EEG were assessed at 3 h intervals before, during, and after one night without sleep. After 11 and 23 h waking, subjects received 200 mg caffeine and placebo in double-blind, cross-over manner. In the placebo condition, sleep deprivation impaired PVT speed more in caffeinesensitive than in caffeine-insensitive men. This difference was counteracted by caffeine. Theta power in waking increased more in a frontal EEG derivation than in a posterior derivation. Caffeine attenuated this power gradient in caffeine sensitive subjects. Sleep loss also differently affected the power distribution Ͻ1 Hz in non-rapid eye movement sleep between caffeine sensitive and insensitive subjects. Also, this difference was mirrored by the action of caffeine. The effects of sleep deprivation and caffeine on sustained attention and regional EEG power in waking and sleep were inversely related. These findings suggest that adenosinergic mechanisms contribute to individual differences in waking-induced impairment of neurobehavioral performance and functional aspects of EEG topography associated with sleep deprivation.

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Slow Oscillations (≤1 Hz) Mediated by GABAergic Interneuronal Networks in Rat Hippocampus

Cited by 87 publications

References 78 publications

Harnessing GABAergic Transmission for Slow Oscillations

Harnessing GABAergic Transmission for Slow Oscillations

Involvement of inward rectifier and M-type currents in carbachol-induced epileptiform synchronization

Adenosinergic Mechanisms Contribute to Individual Differences in Sleep Deprivation-Induced Changes in Neurobehavioral Function and Brain Rhythmic Activity

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