Harnessing GABAergic Transmission for Slow Oscillations

Zhan, Yang

doi:10.1007/s12264-016-0058-1

Cited by 2 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clearly slowed CA1 oscillations recorded in our experiments may be attributed to a largely impaired capacity of the in vitro hippocampus to produce network activity, for example, due to the absence of extra- hippocampal inputs as well as other in vivo machinery or conditions for oscillation generation. However, these in vitro CA1 oscillations may be analogous to theta oscillations, because V m changes occurring at theta bands measured by in vivo whole-cell recording from CA1 PCs have also been found to consist primarily of largeamplitude V m depolarizations (often able to generate neuronal firing) [34][35][36], which are similar to the slow CA1 oscillations shown in this study (Fig. 1).…”

Section: Discussionsupporting

confidence: 68%

Dependence of Generation of Hippocampal CA1 Slow Oscillations on Electrical Synapses

Shen

Liu

et al. 2019

Neurosci. Bull.

View full text Add to dashboard Cite

Neuronal oscillations in the hippocampus are critical for many brain functions including learning and memory. The underlying mechanism of oscillation generation has been extensively investigated in terms of chemical synapses and ion channels. Recently, electrical synapses have also been indicated to play important roles, as reported in various brain areas in vivo and in brain slices. However, this issue remains to be further clarified, including in hippocampal networks. Here, using the completely isolated hippocampus, we investigated in vitro the effect of electrical synapses on slow CA1 oscillations (0.5 Hz-1.5 Hz) generated intrinsically by the hippocampus. We found that these oscillations were totally abolished by bath application of a general blocker of gap junctions (carbenoxolone) or a specific blocker of electrical synapses (mefloquine), as determined by whole-cell recordings in both CA1 pyramidal cells and fast-spiking cells. Our findings indicate that electrical synapses are required for the hippocampal generation of slow CA1 oscillations.

show abstract

Section: Discussionsupporting

confidence: 68%

Dependence of Generation of Hippocampal CA1 Slow Oscillations on Electrical Synapses

Shen

Liu

et al. 2019

Neurosci. Bull.

View full text Add to dashboard Cite

show abstract

“…Although significant progress has been made in clarifying the neuronal circuitry regulating behavioral states, including sleep and wakefulness, some fundamental gaps in our knowledge remain, and this is particularly true with respect to the nature and location of the circuitry regulating sleep [2][3][4]. GABAergic neurons are usually involved in the generation of brain waves [5]. Sleep-promoting GABAergic neurons in the PZ were first reported in 2012 [1].…”

Section: Introductionmentioning

confidence: 99%

Whole-Brain Mapping of Direct Inputs to and Axonal Projections from GABAergic Neurons in the Parafacial Zone

Chu

et al. 2018

Neurosci. Bull.

View full text Add to dashboard Cite

The GABAergic neurons in the parafacial zone (PZ) play an important role in sleep-wake regulation and have been identified as part of a sleep-promoting center in the brainstem, but the long-range connections mediating this function remain poorly characterized. Here, we performed whole-brain mapping of both the inputs and outputs of the GABAergic neurons in the PZ of the mouse brain. We used the modified rabies virus EnvA-ΔG-DsRed combined with a Cre/loxP gene-expression strategy to map the direct monosynaptic inputs to the GABAergic neurons in the PZ, and found that they receive inputs mainly from the hypothalamic area, zona incerta, and parasubthalamic nucleus in the hypothalamus; the substantia nigra, pars reticulata and deep mesencephalic nucleus in the midbrain; and the intermediate reticular nucleus and medial vestibular nucleus (parvocellular part) in the pons and medulla. We also mapped the axonal projections of the PZ GABAergic neurons with adeno-associated virus, and defined the reciprocal connections of the PZ GABAergic neurons with their input and output nuclei. The newly-found inputs and outputs of the PZ were also listed compared with the literature. This cell-type-specific neuronal whole-brain mapping of the PZ GABAergic neurons may reveal the circuits underlying various functions such as sleep-wake regulation.

show abstract

Harnessing GABAergic Transmission for Slow Oscillations

Cited by 2 publications

References 7 publications

Dependence of Generation of Hippocampal CA1 Slow Oscillations on Electrical Synapses

Dependence of Generation of Hippocampal CA1 Slow Oscillations on Electrical Synapses

Whole-Brain Mapping of Direct Inputs to and Axonal Projections from GABAergic Neurons in the Parafacial Zone

Contact Info

Product

Resources

About