Slow-Frequency rTMS Reduces Fibromyalgia Pain: Table 1

Sampson, Shirlene; Rome, Jeffrey D.; Rummans, Teresa A.

doi:10.1111/j.1526-4637.2006.00106.x

Cited by 104 publications

(86 citation statements)

References 22 publications

(20 reference statements)

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“…There were also studies that used low frequency for pain relief in FM. A study that had four patients found pain improvement, but in a second study, no difference was reported between the sham and real treatment groups (31,32). However, in both studies, LF-rTMS stimulation was applied to the prefrontal cortex area.…”

Section: Discussionmentioning

confidence: 99%

“…However, there is no concept that provides a full explanation of the pathogenesis of the disease. Management of FM is frequently multidisciplinary, such as employing education, medications, physical therapies, and cognitive behavioral therapy (6). Usually, the most appropriate treatment is using both pharmacological and non-pharmacological methods together (7).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Yağcı¹,

Ağırman²,

Öztürk³

et al. 2014

Turk J Phys Med Rehab

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ÖzetAmaç: Medikal tedaviye dirençli fibromiyalji hastalarında motor korteks alana uygulanan düşük frekanslı tekrarlayıcı transkraniyal manyetik stimülasyonun (tTMS) etkinliğini araştırmak. Gereç ve Yöntemler: Toplam 25 hasta randomize olarak aktif ve plasebo gruplarına ayrılarak çalışmaya alındı. Aktif tTMS grubu için stimülasyon sol primer motor korteks üzerinden motor eşik değerin %90'ı hesaplanarak 1 Hz ve 20 dakika uygulandı. Her seansta 1200 uyarı olmak üzere, iki hafta boyunca toplam 10 seans tedavi uygulandı. Plasebo grup için, parabolik koil 90° açı ile motor kortekse yerleştirildi ve aynı şekilde toplam 10 seans stimülasyon uygulandı. Sonuçlar, ağrı için vizüel analog skalası (VAS), Fibromiyalji Etkinlik Anketi (FIQ) ve Beck Depresyon Skalası (BDS) ile değerlendirildi. Bulgular: Her iki grupta da tedavi sonunda, 1 ve 3. ay sonunda ağrı derecesinde, FIQ ve BDS'de anlamlı iyileşme gözlendi. Ancak, aktif tTMS grubunda iyileşme plasebo gruba göre daha iyiydi. Tedavi sonu FIQ skorlarında aktif grupta, plasebo gruba göre istatistiksel olarak anlamlı iyileşme gözlendi. Diğer değerlendirmelerde gruplar arasında istatistiksel farklılık saptanmadı. Sonuç: Primer motor korteks üzerine düşük doz tTMS uygulamasının uzun süreli takiplerde fibromiyalji hastalarında plaseboya göre anlamlı iyileşme göstermediği görülmüştür. Anahtar Kelimeler: Fibromiyalji, transkraniyal manyetik stimülasyon, ağrı AbstractObjective: To investigate the effectiveness of low-frequency (LF) repetitive transcranial magnetic stimulation (rTMS) to the motor cortex area in fibromyalgia patients who are resistant to medical treatment. Material and Methods: A total of 25 patients were randomly assigned to the study, who were in the active rTMS (n=13) or sham stimulation (n=12) group. For the rTMS group, the main stimulation parameters were 90% of motor threshold for 60 seconds at 1 Hz and a 45-second interval between each train. Ten sessions of low-frequency rTMS, which had a total of 1200 pulses at each session, were applied to the left primary motor cortex area daily over a period of 2 weeks. For the sham group, the same parabolic coil was placed at 90° angles to the motor cortex area, and the patients received 10 sessions of sham stimulation. The outcome parameters were pain intensity, which was measured by visual analog scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), and the Beck Depression Inventory (BDI). Results: A significant improvement in pain intensity, FIQ, and BDI scores was seen at the 10 th day and first and third months in both groups. Although the mean of parameters of the rTMS groups was better than the sham group, the difference did not reach statistical significance, except FIQ scores at the 10 th day in the real rTMS group. Conclusion: Patients with fibromyalgia who enroll in real TMS did not present significant differences in long-term follow-ups with respect to those who enrolled in the sham TMS group.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Yağcı¹,

Ağırman²,

Öztürk³

et al. 2014

Turk J Phys Med Rehab

View full text Add to dashboard Cite

show abstract

“…3 -12 Additionally, a few studies have demonstrated anti-nociceptive effects with TMS over the prefrontal cortex TMS. [13][14][15][16][17] One significant limitation of much of the research on the effects of TMS on pain perception to date concerns the nature of the placebo or sham conditions employed. When TMS pulses are delivered repetitively (especially prefrontal TMS) it is often experienced as painful (and at a minimum it produces noticeable scalp and/or facial sensations; see Borckardt18).…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of a portable sham transcranial magnetic stimulation system

et al. 2008

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Background-Transcranial magnetic stimulation (TMS) is a relatively noninvasive brain stimulation technology that can focally stimulate the human cortex. One significant limitation of much of the TMS research to date concerns the nature of the placebo or sham conditions employed. When TMS pulses are delivered repetitively (especially prefrontal TMS) it is often experienced as painful. Most sham TMS techniques produce identical sounds to active TMS, but they do not cause much, if any, scalp or facial sensation or discomfort. This is a serious problem when investigators are attempting to evaluate the effects of TMS using traditional sham techniques because of unintended systematic differences between real and sham TMS groups (i.e., confounds). As long as traditional approaches to sham TMS are employed, the validity of the inferences regarding the efficacy of TMS will be limited. While some other sophisticated systems have been developed to address these concerns, they tend to be expensive and lack portability. Portability will likely become more and more important as TMS applications expand into different clinical areas (e.g., TMS in the postanesthesia care unit following surgery)

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“…У пациентов с фибромиалгией ис-следовали эффективность рТМС двух областей: зоны М1 и DLPFC. В 2006 г. было проведено открытое исследова-ние [109], в котором показана эффективность низкочас-тотной рТМС правой DLPFC у 4 пациентов. Однако в ис-следовании схожего дизайна [110] 3 годами позже были получены отрицательные результаты, возможно, из-за малого количества стимулов в течение одной сессии.…”

Section: комплексный регионарный болевой синдром (крбс) 1-го типаunclassified

Repetitive transcranial magnetic stimulation in neurology and psychiatry

Chervyakov

Poydasheva

Korzhova

et al. 2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Slow-Frequency rTMS Reduces Fibromyalgia Pain: Table 1

Abstract: These preliminary findings suggest a possible role for rTMS in treating FM.

Cited by 104 publications

References 22 publications

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Development and evaluation of a portable sham transcranial magnetic stimulation system

Repetitive transcranial magnetic stimulation in neurology and psychiatry

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