SLN based alendronate in situ gel as an implantable drug delivery system – A full factorial design approach

Das, Tanmoy; Venkatesh, M. P.; Kumar, T. M. Pramod; Koland, Marina

doi:10.1016/j.jddst.2019.101415

Cited by 17 publications

(20 citation statements)

References 42 publications

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“…197 Above its critical gelation concentration, gel formation is observed, due to the system reaching a sufficiently high volume fraction of micelles. 190 Other poloxamers that have been incorporated in in vivo injectable systems are (i) poloxamer 188 (P188), 58,[60][61][62][63][64][65][66][67][68][69][70][71][72][73]78,79,84,85,[88][89][90][91] (ii) poloxamer 124 (P124), 59 (iii) poloxamer 403 (P403), 58 (iv) poloxamer 338 (P338) 57 and (v) poloxamer 105 (P105) 106,107 (Table 2). The Pluronic® code is also included in Table 2; the letter describes the morphology of the polymer (F, P and L for flake, paste and liquid), the first (two) number(s) denote approximately the total MM in kg mol −1 , and the last number, when multiplied by 10, denotes the percentage of EG.…”

Section: Poloxamer Basedmentioning

confidence: 99%

“…59,[65][66][67][68][69][70][71][72][73] This strategy has been applied in an attempt to control the thermogelling properties of the final system as desired. In all cases, the main thermoresponsive component was P407, while most of the studies used P188 58,[60][61][62][63][64][65][66][67][68][69][70][71][72][73] as polymer additive/viscosity modifier. Nevertheless, studies on mixtures of P407 with P124, 59 P123 58 and P338 57 have also been reported.…”

Section: Poloxamer Basedmentioning

confidence: 99%

“…These mixtures, loaded with drugs, were tested as drug delivery systems. 57,[59][60][61][62][63][64][66][67][68][69][70][71][72][73] Biocompatibility, 62 enhanced drug bioavailability, 60,61,63,64,73 as well as controlled release 59,[67][68][69][70][71][72][73] were observed. Interestingly, in one of the studies in which PTXcontaining liposomes were injected in tumour-bearing mice, tumour growth was controlled by the local and sustained release of the drug.…”

Section: Poloxamer Basedmentioning

confidence: 99%

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Pre‐clinical and clinical applications of thermoreversible hydrogels in biomedical engineering: a review

Constantinou

Georgiou

2021

Polymer International

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Thermoreversible polymer hydrogels (TRGs) are physical aqueous networks triggered by temperature that find potential applications in tissue engineering (TE) and drug/gene delivery. When systems with lower critical solution temperature (LCST) behaviour are used, the aqueous solution of polymer is mixed with cells or drugs/genes, depending on the desired application, at room temperature and then injected in vivo to form a hydrogel. This in situ forming hydrogel acts as a matrix for tissue regeneration or controlled and targeted release of the compound. This review focuses on discussing the studies in which synthetic TRGs with LCST behaviour have been applied in vivo in model animals. These studies are categorised depending on the general structure of the polymer, as follows: (i) poloxamers (also known as Pluronics®), (ii) degradable polymers, (iii) poly(N-isopropylacrylamide), (iv) poly(organophosphazene) and (v) poly(2-ethyl-2-oxazoline). In general, when the system is optimised, TRGs provide sustained and topical release of the drugs, thus minimising the undesired side effects. When applied in the TE field, tissue formation was observed. Interestingly, two polymers have reached clinical trials, namely poloxamer 407 (P407, Pluronic® F127, often combined with P188, F68) and Regel® (the formulation of Regel® with the anticancer agent paclitaxel is known as Oncogel®), indicating the challenges that need to be overcome before successful application in clinics.

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Section: Poloxamer Basedmentioning

confidence: 99%

Section: Poloxamer Basedmentioning

confidence: 99%

Section: Poloxamer Basedmentioning

confidence: 99%

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Pre‐clinical and clinical applications of thermoreversible hydrogels in biomedical engineering: a review

Constantinou

Georgiou

2021

Polymer International

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“…One of the non-viral methods, solid lipid nanoparticles (SLN); are non-toxic carrier systems stabilized by surfactants and made from solid lipids for controlled and targeted delivery. Their advantageous features are, biocompatibility, assembling of hydrophilic and hydrophobic drugs, maintain the release of the drug and avoid photochemical, chemical, or oxidative degradation [12]. These systems have several advantages such as improved transfection, reduced immunogenicity, large gene package size, ease of manufacture, protection from degradation, prolong circulation of the nanoparticles (NPs), reduce side effects, realize controlled release of the contents, and enhanced targeted delivery [13].…”

Section: Original Articlementioning

confidence: 99%

Optimization and screening of solid lipid nanoparticle production for gene delivery by factorial design and response surface methodology

Akbaba¹,

Ozder²

2021

j-ebr

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A successful gene therapy requires a delivery system for overcoming various biological barriers. For this, we adapted the factorial design and response surface methodology to the cationic solid lipid nanoparticle production process. Methods: Screening and optimization of formulations were carried out with factorial design with 3 factors and 3 levels using Box-Behnken Design. Then, solid lipid nanoparticles were physicochemically characterized. Furthermore, optimal SLN formulation is examined in terms of complex formation with plasmid DNA, its protection potential against nucleases, cytotoxicity profile, and storage stability. Results: Response-surface analyses demonstrated that the selected quadratic model holds significance for particle size and zeta potential. The interaction of independent variables was statistically determined. Optimization and prediction were performed using obtained second-order polynomial equations. Optimal formulation and complexes were found to be nanosized, positively charged and their polydispersity-index values below 0.3 as an indicator of being monodispersed. Cytotoxicity of the optimal formulation is compatible for further studies and no significant increase was observed in particle size until day 21 and until day 60 for polydispersity-index. Conclusion:Optimal formulation provides a good basis as a gene delivery system was produced with developed systematic. Briefly, this methodology could be used to obtain SLNs with desired conditions.

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“…From the results, they were concluded that alendronate -solid lipid nanoparticle based in-situ gel for the treatment of osteoporosis could be suitable drug delivery system over conventional dosage 25. …”

mentioning

confidence: 99%

Experimental Design: Approaches and Applications in Development of Pharmaceutical Drug Delivery System

Supare

Wadher

Umekar

2021

J. Drug Delivery Ther.

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Conventionally, all the delivery systems have been prepared by methodology of trial and error concept by manipulating one variable at a Time, but attainment of optimal formulation is not achievable. The systematic approach Design of Experiments (DoE) enables researchers to provide appropriate outline to develop a best optimized delivery system. Optimization techniques using DoE helps to provide effective and economical analytical tools to find the perfect solution for a particular problem. In screening designs, there is large number of screening factors in minimum number of experiments and beneficial to minimize the variables in a desired size therefore further experimentation may be performed easily by using these variables. Experimental designs and optimization techniques are the tools which are systematically used to categorize various types of problems that may influence development of pharmaceutical delivery system. Use of experimental design is the best approach to the screening and optimization of experimental factors. In the present review article we have focused on application of practically applicable experimental designs and optimization techniques for the development of quality and efficacious of pharmaceutical formulations such as, nanoparticles, Phytosomes, microspheres, liposomes, micells, films, nanostructured lipid carriers and tablets and which type of factors to be considered while optimization are also discussed. Keywords: Experimental design, Optimization, Applications, Drug delivery, Phytosomes, Nano delivery System.

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SLN based alendronate in situ gel as an implantable drug delivery system – A full factorial design approach

Cited by 17 publications

References 42 publications

Pre‐clinical and clinical applications of thermoreversible hydrogels in biomedical engineering: a review

Pre‐clinical and clinical applications of thermoreversible hydrogels in biomedical engineering: a review

Optimization and screening of solid lipid nanoparticle production for gene delivery by factorial design and response surface methodology

Experimental Design: Approaches and Applications in Development of Pharmaceutical Drug Delivery System

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