Sleeve Gastrectomy—A “Food Limiting” Operation

Melissas, John; Daskalakis, Markos; Koukouraki, Sophia; Askoxylakis, Ioannis; Metaxari, Maria; Dimitriadis, Efstathios; Stathaki, Maria; Papadakis, John A.

doi:10.1007/s11695-008-9634-4

Cited by 250 publications

(163 citation statements)

References 29 publications

(36 reference statements)

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“…Melissas et al 7 showed that solid gastric emptying before and after LSG (with morbidly obese patients acting as their own controls) was accelerated. Braghetto et al 8 confirmed this in their subsequent study, showing acceleration for liquids and solids (78 -38 min).…”

Section: Discussionmentioning

confidence: 99%

Gastric Emptying Time after Laparoscopic Sleeve Gastrectomy

Singh¹,

Aggarwal²

2018

Int. J. Curr. Res. Biol. Med.

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Background : Bariatric surgery remains the only proven mechanism for inducing sustained and significant weight loss for morbidly obese patients. Glycemic control is better after the surgery. Changes in gastric emptying patterns which occurs in patients after surgical treatment may be contributing to weight loss and better glucose metabolism. The aim of the study is to see effect of Laparoscopic sleeve gastrectomy (LSG) on gastric emptying time. Methods: This was a prospective observational study. 24 patients were recruited who underwent LSG. The patients were submitted to the Gastric emptying study preoperatively and at 3 months after LSG. Gastric emptying time for solids was done. Results: At 3 months the Excess weight loss was 24 %. Five of the 7 patients with diabetes had complete resolution. There was a significant decrease in the mean T 1/2 of gastric empting at 3 months postoperatively (83.4 min vs 33.3 min). No correlation was found between Gastric emptying half time and %EWL at 3 months. Conclusion: Gastric emptying after LSG is accelerated in the majority of patients as shown by significantly reduced gastric emptying time. A faster gastric emptying could be one of the mechanisms contributing to weight loss after LSG

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Section: Discussionmentioning

confidence: 99%

Gastric Emptying Time after Laparoscopic Sleeve Gastrectomy

Singh¹,

Aggarwal²

2018

Int. J. Curr. Res. Biol. Med.

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“…Ghrelin is predominantly secreted by the gastric fundus and has various effects on food intake, such as increasing appetite and influencing chewing time, taste preferences, and food perception, as well as increasing gastrointestinal motility and decreasing insulin secretion. In non-obese individuals, ghrelin levels are highest immediately prior to a meal and decrease rapidly upon the initiation of food intake (13). Conversely, obesity is associated with reduced ghrelin levels, and food intake fails to modulate the levels of plasma ghrelin.…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, obesity is associated with reduced ghrelin levels, and food intake fails to modulate the levels of plasma ghrelin. Dietaryinduced weight loss is linked to increased ghrelin secretion, which has been postulated to contribute to the poor long-term success rates of dietary weight loss programmes by promoting increased food consumption, although this remains unproven (12,13).…”

Section: Discussionmentioning

confidence: 99%

Effect of Resected Gastric Fundus Fat on Ghrelin Tissue Levels: A Prospective Study

Durmuş¹,

Durmus²,

Abahuni³

et al. 2017

chr

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Introducere: Obezitatea este în prezent o problemă de sănătate importantă, care evoluează rapid la nivel mondial. În ultimii ani numărul intervenţiilor chirurgicale conexe obezităţii a crescut. Cea mai frecventă preocedură chirurgicală a obezităţii este gastrectomia longitudinală laparoscopică (LSG). Scopul acestui studiu a fost compararea expresiei genetice a hormonului gherlin în zone diferite ale stomacului. Material şi metodă: 19 pacienţi obezi supuşi LSG au fost examinaţi în cadul acestui studiu. Grăsimea din două părţi diferite ale stomacului (fundus şi zona superioara a acestuia) a fost analizată prin testul ELISA (enzyme-linked immunosorbent assay). Au fost aplicate tehnici de izolare ARN, ADN complementar şi RQ-PCR (detecţie în timp real: real-time PCR). În plus, un kit de analiză ELISA a fost folosit pentru a măsura cantitatea de gherlin la pacienţii obezi. Au fost comparate statistic nivelele de gherlin din fundus şi zona superioara a acestuia. Rezultate: În cazul tuturor celor 19 pacienţi, nivelul mediu de gherlin a fost mai mare de 30. Nivelul mediu de ghelin a stratului de grăsime localizat în partea superioara a fundusului a fost mai mare de 30 în cazul a 4 pacienţi; nivelul mediu a fost 5 la restul pacienţilor. Am observat o diferenţă statistică semnificativă a nivelului de gherlin între fundus şi stratul de grăsime al acestuia. Concluzie: Recoltarea ţesutului gras din fundus nu este practicată de rutină în timpul LSG. Totuşi, creşterea nivelului de hormon gherlin în acest ţesut necesită prelevarea de ţesut din fundus în timpul intervenţiei chirurgicale.Cuvinte cheie: gastrectomia longitudinală laparoscopică (LSG), nivel de gherlin, ţesut gras gastric, fundus Abstract Introduction: Obesity is currently an important health problem that is rapidly

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“…This phenomenon depends on the increased speed of gastric emptying after surgery and results in an increase in GLP1 secretion by L cells. 92,93 Recent studies have shown that vertical gastrectomy as an isolated and definite bariatric surgery is as effective as the Fobi-Capella procedure for the control of comorbidities; in addition, it provides the potential to avoid some of the associated complications. [94][95][96][97] Although the surgical procedure is simpler, research investigating humans who were undergoing vertical gastrectomy alone demonstrated the presence of limitations 98 and complications.…”

Section: Introductionmentioning

confidence: 99%

“…One can infer that the metabolic benefits obtained by such procedures are almost exclusively due to ileal interposition. Note that the increased speed of intestinal transit caused by vertical gastrectomy 92,93 may contribute to the more rapid arrival of undigested food in the region of ileal segment interposition and thus contribute to the production of GLP-1 by L cells in the ileum. Nevertheless, the isolated ileal interposition has proven to be effective in correcting dysmetabolism in several animal studies.…”

Section: Introductionmentioning

confidence: 99%

Organic consequences of ileal transposition in rats with diet-induced obesity

et al. 2011

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INTRODUCTION:The clinical management of metabolic syndrome -especially diabetes mellitus type 2 -is notoriously complex due to the progressive nature of this disease. At present, there is a need for a surgical procedure that is effective for the treatment of diabetes mellitus type 2, even in non-obese individuals. The isolated ileal transposition theory could lead to an effective alternative therapy. This intervention has not yet been performed in humans, and there are no reports of its use in an experimental model of diet-induced metabolic syndrome. OBJECTIVES:The objective of this study is to evaluate the physiological effects of ileal transposition in rats with diet-induced metabolic syndrome. The effects of this procedure on glucose and lipid metabolism will be assessed. METHODS:Forty 12-week-old male rats (albino Rattus norvegicus, Wistar, 2BAW, heterogeneous) will be divided into four groups of 10 animals each: the ileal transposition group (TG) comprising animals on a hypercaloric-hyperlipidic diet; the sham group (SG) containing animals that receive the same diet and undergo the sham surgery; control group 1 (CG1), which will receive a hypercaloric-hyperlipidic diet and will not undergo surgery; and control group 2 (CG2), which will consume standard feed and will not undergo surgery. The surgeries will be performed in 20-week-old animals.Blood samples for laboratory testing will be collected from 12-week-old animals on the day of surgery and after eight postoperative weeks, following determination of the weights of the animals and the administration of anesthesia. The levels of serum glucose, insulin, triglycerides, total cholesterol and fractions, glucagon-like peptide-1, C-peptide and glycated hemoglobin will be assessed in all of the animals. The insulin tolerance test will be performed using PRISMA software, and insulin resistance will be calculated by the HOMA-IR indirect test. On specific days, two 20-week-old rats will be separated and randomly distributed in TG and SG. These animals will be followed until the eighth postoperative week. Subsequently, they will be euthanized, and the retroperitoneal and periepididymal fat deposits will be collected and weighed using a precision scale. In addition, the pancreas, liver and intestinal segments will be sent for pathological and immunohistochemical studies.

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Sleeve Gastrectomy—A “Food Limiting” Operation

Cited by 250 publications

References 29 publications

Gastric Emptying Time after Laparoscopic Sleeve Gastrectomy

Gastric Emptying Time after Laparoscopic Sleeve Gastrectomy

Effect of Resected Gastric Fundus Fat on Ghrelin Tissue Levels: A Prospective Study

Organic consequences of ileal transposition in rats with diet-induced obesity

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