Sleep restriction by forced activity reduces hippocampal cell proliferation

Román, Viktor; Borght, Karin van der; Leemburg, Susan; Zee, Eddy A. van der; Meerlo, Peter

doi:10.1016/j.brainres.2005.10.020

Cited by 74 publications

(56 citation statements)

References 29 publications

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“…The reduction of cell proliferation and adult neurogenesis has also been shown in previous studies by using different methods of sleep deprivation, such as the treadmill and disk-over-water methods (14)(15)(16)(17). With the disk-over-water paradigm, animals are motivated to remain awake, because continued sleep runs the risk of falling into water; animals can escape this consequence if they move with the rotating disk.…”

Section: Discussionmentioning

confidence: 62%

Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids

Mirescu

Peters²,

Noiman³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

202

137

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Prolonged sleep deprivation is stressful and has been associated with adverse consequences for health and cognitive performance. Here, we show that sleep deprivation inhibits adult neurogenesis at a time when circulating levels of corticosterone are elevated. Moreover, clamping levels of this hormone prevents the sleep deprivation-induced reduction of cell proliferation. The recovery of normal levels of adult neurogenesis after chronic sleep deprivation occurs over a 2-wk period and involves a temporary increase in new neuron formation. This compensatory increase is dissociated from glucocorticoid levels as well as from the restoration of normal sleep patterns. Collectively, these findings suggest that, although sleep deprivation inhibits adult neurogenesis by acting as a stressor, its compensatory aftereffects involve glucocorticoid-independent factors. dentate gyrus ͉ stress ͉ corticosterone ͉ cell proliferation ͉ adrenal steroids

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Section: Discussionmentioning

confidence: 62%

Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids

Mirescu

Peters²,

Noiman³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

202

137

View full text Add to dashboard Cite

show abstract

“…Experimental studies show that prolonged sleep restriction or disruption affects hippocampal integrity (Guzman-Marin et al, 2006, Kopp et al, 2006, McDermott et al, 2003, Roman et al, 2005a. For example, in young male rats, one month of chronic sleep restriction reduced dorsal hippocampal volume by 10% (Novati et al, 2011).…”

Section: Sleep and Its Effect On Neuroprogressionmentioning

confidence: 99%

“…For example, in young male rats, one month of chronic sleep restriction reduced dorsal hippocampal volume by 10% (Novati et al, 2011). Hippocampal cell proliferation was also affected by a single day of sleep deprivation in rats (Roman et al, 2005a). Clinical studies have also reported a reduction in hippocampal volume in primary insomnia and sleep apnoea (Morrell et al, 2003, Riemann et al, 2007.…”

Section: Sleep and Its Effect On Neuroprogressionmentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

490

412

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Research on major depression has confirmed that it is caused by an array of biopsychosocial and lifestyle factors. Diet, exercise and sleep are three such influences that play a significant mediating role in the development, progression and treatment of this condition. This review summarises animal and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression, namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (HPA) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. Increased attention in future clinical studies on the influence of diet, sleep and exercise on major depressive disorder and investigations of their effect on physiological processes will help to expand our understanding and treatment of major depressive disorder. Mental health interventions, taking into account the bidirectional relationship between these lifestyle factors and major depression are also likely to enhance the efficacy of interventions associated with this disorder.

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“…En el caso de la proliferación en hipocampo adulto, se sabe que las células progenitoras que son originadas en la zona subgranular del giro dentado tienen características morfológicas de células gliales (Seri et al, 2006), es decir, aún no son neuronas propiamente dichas (Cameron & McKay, 1999;Christie & Cameron, 2006;Gould, Tanapat, McEwen, Flugge & Fuchs, 1998;Jankovski, Garcia, Soriano & Sotelo, 1998;Kang et al, 2013;Pham, McEwen, LeDoux & Nader, 2005;Schoenfeld & Gould, 2013;Toriumi et al, 2012;Yau et al, 2011). El mecanismo de proliferación puede ser modificado por varios factores entre los cuales se pueden contar determinados fármacos y compuestos (Bachstetter et al, 2010;Fujita et al, 2008;Huang et al, 2012;Kauffman, 1969;Kippin, Kapur & van der Kooy, 2005;Kudo et al, 2003;Rice, Bullock & Shelton, 2004;Tung, Herrera, Fornal & Jacobs, 2008;Zusso et al, 2008), el ejercicio (Crews, Nixon & Wilkie, 2004;Itoh et al, 2011;Nam et al, 2013;Wu et al, 2008), la nutrición (Goustard-Langelier, Koch, Lavialle & Heberden, 2013;Liu & Mori, 2005), la privación de sueño y en general las alteraciones del ritmo sueño-vigilia (Guzman-Marin et al, 2003;Junek, Rusak & Semba, 2010;McEwen, 2006;Roman, van der Borght, Leemburg, Van der Zee & Meerlo, 2005;Tung, Takase, Fornal & Jacobs, 2005). Existen evidencias de que la proliferación neuronal hipocampal está relacionada con aprendizaje de tareas de cond...…”

Section: Efectos Del Estrés Sobre La Plasticidad Neuronal Y La Neurogunclassified

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

Zarate¹,

Parra²,

Acevedo-Triana

et al. 2014

Univ Psychol

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r e S u M e n Grandes esfuerzos han sido llevados a cabo para entender los componentes psicobiológicos del estrés y de algunas de las psicopatologías relacionadas con él, tales como los trastornos de ansiedad (ansiedad generalizada o crisis de pánico) e incluso la depresión. Existen evidencias de que procesos como la neurogénesis y la plasticidad se ven enormemente afectados por muchos factores, entre ellos el estrés. En esta revisión se presentan algunos de los principales conceptos sobre la relación entre estrés, plasticidad y neurogé-nesis, a los que se ha llegado a partir de investigaciones realizadas -principalmente en modelos animales-, desde hace algunas décadas. Se realizará una diferenciación entre los efectos ocasionados por estrés crónico y agudo, tratando de establecer las interacciones que sobre estos efectos ejercen algunas variables tales como el género o el rango de edad, se enfatizarán los efectos comportamentales para finalmente revisar algunas de las formas de intervención actualmente más usadas para el tratamiento del estrés. Palabras clave estrés; plasticidad; neurogénesis a B S t r a C tThere is a growing interest in the comprehension of psychobiological mechanisms underlying stress and its relationships with many psychopathologies such as anxiety (i.e. generalized anxiety and panic attacks) or depression. There are several reports on the effects of stress on neurogenesis and plasticity. This review will discuss some of the core concepts on the relation between stress, plasticity and neurogenesis obtained during the last decades from research -mainly based in the use of animal models. The distinguishable effects between acute and chronic stress will also be discussed in relation to other factors as genre and age with an emphasis on behavioral effects. Some current therapeutic approaches will be reviewed as well.

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Sleep restriction by forced activity reduces hippocampal cell proliferation

Cited by 74 publications

References 29 publications

Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids

Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

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