Sleep quality and dialysis efficacy affect functional capacity in patients receiving haemodialysis therapy

Sakkas, Giorgos K.; Liakopoulos, Vassilios; Karatzaferi, Christina; Stefanidis, Ioannis

doi:10.1093/ndt/gfn048

Cited by 4 publications

(5 citation statements)

References 5 publications

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“…Since previous trials have been showing that reduced leg-muscle strength was associated with lower outcomes in functional capacity among hemodialysis patients [44,45], it is possible that the loss of strength due to long-term detrained accounted for the decreased physical component of QoL observed in the present study. Nevertheless, other parameters affecting muscle mass such as sleep quality has been associated with impaired functional capacity among hemodialysis patients [46].…”

Section: Discussionmentioning

confidence: 99%

Effects of 12 months of detraining on health-related quality of life in patients receiving hemodialysis therapy

et al. 2020

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Purpose Limited data exist regarding the effects of detraining on functional capacity and quality of life (QoL) in the hemodialysis population. The aim of the current study was to assess whether the discontinuation from a systematic intradialytic exercise training program will affect aspects of health-related QoL and functional capacity in hemodialysis patients. Methods Seventeen hemodialysis patients (12 Males/5 Females, age 60.8 ± 13.6 year) participated in this study. Patients were assessed for functional capacity using various functional capacity tests while QoL, daily sleepiness, sleep quality, depression and fatigue were assessed using validated questionnaires at the end of a 12-month aerobic exercise program and after 12 months of detraining. Results The detraining significantly reduced patients' QoL score by 20% (P = 0.01). More affected were aspects related to the physical component summary of the QoL (P < 0.001) rather than those related to the mental one (P = 0.096). In addition, the performance in the functional capacity tests was reduced (P < 0.05), while sleep quality (P = 0.020) and daily sleepiness scores (P = 0.006) were significantly worse after the detraining period. Depressive symptoms (P = 0.214) and the level of fatigue (P = 0.163) did not change significantly. Conclusions Detraining has a detrimental effect in patients' QoL, functional capacity and sleep quality. The affected physical health contributed significantly to the lower QoL score. It is crucial for the chronic disease patients, even during emergencies such as lockdowns and restrictions in activities to maintain a minimum level of activity to preserve some of the acquired benefits and maintain their health status.

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Section: Discussionmentioning

confidence: 99%

Effects of 12 months of detraining on health-related quality of life in patients receiving hemodialysis therapy

et al. 2020

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“…Patients on maintenance HD therapy share many similarities to those suffering by CFS since they experience generalized weakness (Johansen et al, 2003), exercise in tolerance (Koufaki et al, 2002), and disturbed sleep (Sakkas et al, 2008a) all leading to a sense of generalized fatigue and “lack of energy” (McCann and Boore, 2000; Kovacs et al, 2011). This chronic state of “HD Fatigue” among HD patients satisfies one major requirement for the diagnosis of CFS which is persistent fatigue present at least during 50% of the time over a period of at least 6 months (Jason et al, 2003).…”

Section: What We Can Learn From Chronic Fatiguementioning

confidence: 99%

“…Furthermore, the majority of HD patients complain of “brain fog” and lethargy (Caplin et al, 2011) especially in the hours post dialysis (Tryc et al, 2011), while one out of two have very low quality of sleep and suffer from daily sleepiness (Sakkas et al, 2008a; Giannaki et al, 2011). Moreover, the HD procedure per se filters away many small molecules involved in metabolism (glucose, amino acids, minerals, hormones etc.)…”

Section: Hypothesis Of “Hemodialysis Fatigue Syndrome”mentioning

confidence: 99%

“…While various interventions in stable HD patients have helped these patients improve their functionality, they still have not proven enough to bring their muscle quality and quantity up to the levels of a healthy sedentary person (Sakkas et al, 2003b; Johansen et al, 2006). Moreover, patients present with sleep problems (Sakkas et al, 2008a), neurological and quality of life issues (Giannaki et al, 2011), anxiety, and/or symptoms of depression but most notably they complain of chronic fatigue and “lack of energy” (McCann and Boore, 2000). …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hemodialysis Fatigue: Just “Simple” Fatigue or a Syndrome on Its Own Right?

Sakkas¹,

Karatzaferi²

2012

Front. Physio.

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“…Moreover, various groups turned their attention to exercise and other interventions to remedy or halt muscle deterioration in pre-dialysis (e.g., Clyne et al, 1991 ) and dialysis patients (e.g., Sakkas et al, 2003b ; Johansen et al, 2006 ). Despite the evident improvements in exercise capacity and muscle morphology (Sakkas et al, 2003b , 2008a ), in increasing muscle mass with steroid supplementation (Topp et al, 2003 ), in improving sleep and overall quality of life (Sakkas et al, 2008c ) it appears that interventions so far cannot restore muscle functionality in ESRD patients to the level of age-matched healthy sedentary individuals (Sakkas et al, 2003b , 2008a ; Giannaki et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Uremic myopathy: is oxidative stress implicated in muscle dysfunction in uremia?

et al. 2015

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Renal failure is accompanied by progressive muscle weakness and premature fatigue, in part linked to hypokinesis and in part to uremic toxicity. These changes are associated with various detrimental biochemical and morphological alterations. All of these pathological parameters are collectively termed uremic myopathy. Various interventions while helpful can't fully remedy the pathological phenotype. Complex mechanisms that stimulate muscle dysfunction in uremia have been proposed, and oxidative stress could be implicated. Skeletal muscles continuously produce reactive oxygen species (ROS) and reactive nitrogen species (RNS) at rest and more so during contraction. The aim of this mini review is to provide an update on recent advances in our understanding of how ROS and RNS generation might contribute to muscle dysfunction in uremia. Thus, a systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines. While few studies met our criteria their findings are discussed making reference to other available literature data. Oxidative stress can direct muscle cells into a catabolic state and chronic exposure to it leads to wasting. Moreover, redox disturbances can significantly affect force production per se. We conclude that oxidative stress can be in part responsible for some aspects of uremic myopathy. Further research is needed to discern clear mechanisms and to help efforts to counteract muscle weakness and exercise intolerance in uremic patients.

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Sleep quality and dialysis efficacy affect functional capacity in patients receiving haemodialysis therapy

Cited by 4 publications

References 5 publications

Effects of 12 months of detraining on health-related quality of life in patients receiving hemodialysis therapy

Effects of 12 months of detraining on health-related quality of life in patients receiving hemodialysis therapy

Hemodialysis Fatigue: Just “Simple” Fatigue or a Syndrome on Its Own Right?

Uremic myopathy: is oxidative stress implicated in muscle dysfunction in uremia?

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