Hemodialysis Fatigue: Just “Simple” Fatigue or a Syndrome on Its Own Right?

Sakkas, Giorgos K.; Karatzaferi, Christina

doi:10.3389/fphys.2012.00306

“…Research also showed a significant association between fatigue and cardiovascular disease (CVD), another inflammatory and O&NS disease [194]. There is also an increased incidence of chronic fatigue in hemodialysis patients ('hemodialysis fatigue') [195]. Since hemodialysis is accompanied by inflammatory and O&NS processes, the latter could also explain the increased incidence of fatigue during hemodialysis.…”

Section: Neuroimmune Pathways In Sickness Behavior and Me/cfsmentioning

confidence: 99%

A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior

Morris¹,

Anderson²,

Gałecki

³

et al. 2013

BMC Med

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It is of importance whether myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a variant of sickness behavior. The latter is induced by acute infections/injury being principally mediated through proinflammatory cytokines. Sickness is a beneficial behavioral response that serves to enhance recovery, conserves energy and plays a role in the resolution of inflammation. There are behavioral/symptomatic similarities (for example, fatigue, malaise, hyperalgesia) and dissimilarities (gastrointestinal symptoms, anorexia and weight loss) between sickness and ME/CFS. While sickness is an adaptive response induced by proinflammatory cytokines, ME/CFS is a chronic, disabling disorder, where the pathophysiology is related to activation of immunoinflammatory and oxidative pathways and autoimmune responses. While sickness behavior is a state of energy conservation, which plays a role in combating pathogens, ME/CFS is a chronic disease underpinned by a state of energy depletion. While sickness is an acute response to infection/injury, the trigger factors in ME/CFS are less well defined and encompass acute and chronic infections, as well as inflammatory or autoimmune diseases. It is concluded that sickness behavior and ME/CFS are two different conditions.

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“…Despite the popularity of antioxidants as nutritional supplements, Hernández et al report that their utility for either minimizing or speeding recovery from fatigue appears to be limited to specific muscle types. Moreover, Bogdanis' (2012) section on neural factors opens the discussion on the role of non-muscle factors in fatigue and serves as a bridge to the articles by Kobilo and van Praag (2012), Sakkas and Karatzaferi (2012), and Noakes (2012). …”

mentioning

confidence: 99%

“…In their opinion article, Sakkas and Karatzaferi (2012) consider available evidence on the complex symptomatology of fatigue in renal patients on hemodialysis treatment. By drawing analogies to Chronic Fatigue Syndrome, Sakkas and Karatzaferi (2012) present the view that fatigue, as experienced by patients undergoing routine hemodialysis, might be better addressed by caregivers as a syndrome and not with isolated measures since its apparent complexity requires a cross-disciplinary therapeutic approach. While hemodialysis and some other patients may be afflicted with specific syndromes, the rest of us have all heard the expression “mind over matter.” Does it apply to muscle?…”

mentioning

confidence: 99%

Muscle fatigue and muscle weakness: what we know and what we wish we did

Karatzaferi¹,

Chase²

2013

Self Cite

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“…Despite the popularity of antioxidants as nutritional supplements, Hernández et al report that their utility for either minimizing or speeding recovery from fatigue appears to be limited to specific muscle types. Moreover, Bogdanis' (2012) section on neural factors opens the discussion on the role of non-muscle factors in fatigue and serves as a bridge to the articles by Kobilo and van Praag (2012), Sakkas and Karatzaferi (2012), and Noakes (2012).…”

mentioning

confidence: 99%

“…In their opinion article, Sakkas and Karatzaferi (2012) consider available evidence on the complex symptomatology of fatigue in renal patients on hemodialysis treatment. By drawing analogies to Chronic Fatigue Syndrome, Sakkas and Karatzaferi (2012) present the view that fatigue, as experienced by patients undergoing routine hemodialysis, might be better addressed by caregivers as a syndrome and not with isolated measures since its apparent complexity requires a cross-disciplinary therapeutic approach. While hemodialysis and some other patients may be afflicted with specific syndromes, the rest of us have all heard the expression "mind over matter."…”

mentioning

confidence: 99%

Muscle fatigue and muscle weakness: what we know and what we wish we did

2013

Frontiers Research Topics

0

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This Research Topic on muscle fatigue and muscle weakness presents the latest ideas, arguments, and evidence from investigations at the molecular level to macroscopic observations on whole animals including humans, in an effort to identify critical factors underlying fatigue and weakness in health and disease. Skeletal muscles confer movement to the human body using vast amounts of energy provided through complex metabolic pathways such that whole body mobility and energy balance are largely dictated by muscle activity. Conversely, muscle function reflects overall health status as exercise history and chronic conditions affect either or both muscle quality, including protein and fat content, and muscle mass. In health, muscle fatigue is temporary and recovery occurs rapidly, and recreational or competitive athletes are always pursuing the next best fatigue "fix." However, after inactivity-whether due to lifestyle choices, injury or chronic disease-muscle fatigue may occur prematurely and persist, endangering a person's safety because weakness can lead to falls that may result in loss of independence. Individuals are then trapped in a self-perpetuating, vicious cycle of inactivity, disuse muscle atrophy/weakness, and metabolic disturbance that compounds morbidity (i.e., causing metabolic syndrome, obesity, hypertension, cachexia) and eventually premature death. Such issues transcend many scientific disciplines and it becomes evident that not only recognizing fundamental factors in muscle fatigue and muscle weakness is necessary, but also evaluating their interaction with factors outside of the muscle is essential if we aspire to design better interventions that improve muscle function and thus improve quality of life and life prognosis for the ageing population and chronic disease patients.Fatigue and weakness may stem from changes within myocytes that affect cross-bridge function or Ca 2+ activation, to changes within the circulation or function of the nervous system. Within myocytes, metabolic products of ATP hydrolysis in the cytoplasm such as inorganic phosphate (Pi), protons (H + or pH), and ADP have often been considered as agents that could disrupt force generation at the sarcomere level (Fabiato and Fabiato, 1978;

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Hemodialysis Fatigue: Just “Simple” Fatigue or a Syndrome on Its Own Right?

Cited by 36 publications

References 49 publications

A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior

A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior

Muscle fatigue and muscle weakness: what we know and what we wish we did

Muscle fatigue and muscle weakness: what we know and what we wish we did

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