Sleep Problems and Daytime Sleepiness in Children with Nocturnal Enuresis

Gu, Yun; Kwon, Jae Wan; Lee, Gi-Min; Lee, Su Jeong; Suh, Hyo Rim; Min, Seoyeon; Roh, Da Eun; Jo, Tae Kyoung; Baek, Hee Sun; Hong, Suk Jin; Seo, Hye-Eun; Cho, Min Hyun

doi:10.3339/jkspn.2016.20.2.50

Cited by 3 publications

(3 citation statements)

References 19 publications

(13 reference statements)

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“…40 However, according to Gu et al, there was no significant difference in sleep architecture between children with nocturnal enuresis and healthy controls. 41 In our study, REM sleep percentage was low in children with nocturnal enuresis compared with controls. This polysomnographic finding may be explained by the first-night effect.…”

Section: Polysomnographic Findings In Nocturnal Enuresismentioning

confidence: 39%

Sleep Architecture in Valproate-Induced Nocturnal Enuresis in Primary School and Preschool Children

et al. 2020

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Nocturnal enuresis is one of the side effects of valproic acid treatment, and generally underdiagnosed by clinicians. Studies reported that a variable incidence of valproic acid–induced nocturnal enuresis is 2.2% to 24% with unclear explanations of the reasons behind valproic acid–induced nocturnal enuresis. A retrospective study was carried out on 260 children (aged 5-12 years) diagnosed with idiopathic epilepsy, treated with valproic acid to evaluate the nocturnal enuresis secondary to valproic acid, and to discuss the characteristics of their sleep architecture. Nocturnal enuresis was reported in 28 (10.7%) patients after a mean exposure time to valproate of 18.78±8.4 days. Nocturnal enuresis was significantly associated with younger age and serum level of valproate ( P = .05). The polysomnographic study suggested that the underlying mechanism may be related to impaired sleep efficiency, frequent arousals, prolonged sleep latency, snoring, or increased sleep depth which may impair a child’s ability to awaken to the sense of bladder fullness or contractions. Clinical trial registration: ClinicalTrials.gov identifiers: NCT04191863

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Section: Polysomnographic Findings In Nocturnal Enuresismentioning

confidence: 39%

Sleep Architecture in Valproate-Induced Nocturnal Enuresis in Primary School and Preschool Children

et al. 2020

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“…Some studies have demonstrated that children who suffered from enuresis have disrupted sleep with several intermittent arousals that result in fragmentation of sleep and poor quality of sleep [20]. Some previous studies have shown an association between sleep disturbance and NE [21], which confirmed with Nevéus' report stating that the sleep problem is closely related to the pathophysiology of nocturnal enuresis [22]. Children suffered from NE may have a high threshold of cortical arousability, so they will not wake up when the bladder reaches its maximum capacity.…”

Section: Discussionmentioning

confidence: 99%

Decreased vitamin D levels in children with primary mono-symptomatic nocturnal enuresis

El-Baz

Abdelsayed

Abdel-Hafeez³

et al. 2021

Egypt J Med Hum Genet

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Background Nocturnal enuresis (NE) is a common voiding problem in pediatric populations. Relatively, few studies have investigated the 25-Hydroxyvitamin D and NE associations in children, which may open up a new research area on the effect of vitamin D as nutritional therapy in the treatment of NE. The aim of this study was to determine the level of 25-hydroxyl vitamin D among children and adolescents with nocturnal enuresis in comparison to non-enuretic Egyptian children. Results Fifty children (24 females, 26 males) who presented with primary mono-symptomatic nocturnal enuresis (PMNE) and 50 healthy children (23 females, 27 males) were recruited in this study. A structured questionnaire focusing on demographic, socioeconomic, and frequency of bed-wetting were collected, and vitamin D serum levels were assessed in all children. In the NE group, the mean value of serum vitamin D levels was lower than the control (19.0 ± 6.5 versus 23.89 ± 4.19; P < 0.0001). Serum 25-hydroxyvitamin D levels were abnormal (< 20 ng/mL) in 46% of children with NE and 16% of controls (P < 0.001). The higher bed-wetting frequencies were associated with lower levels of 25(OH) D (Every night: 7.0 ± 1.4, 3–5 time/week: 11.2 ± 1.7, 1–3 times/week: 17.6 ± 3.7, < 2times/week: 22.4 ± 2.9, Once/6 month: 24.1 ± 4.3 (ng/ml), P < 0.001). Conclusion A difference in serum 25-hydroxyvitamin D levels was found between the two study groups. There is a need for more studies to explain vitamin D deficiency in larger series so that this test can be used in regular enuretic child investigations.

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“…According to some authors, children who have enuresis are more likely to have periodic limb movements and OSA. As the etiology of NE is unclear and complicated, it makes the treatment lengthy and frequently accompanied by relapses [ 7 ]. NE may occur in children with obstructive SDB due to the decrease in the arousal response [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Sleep-Disordered Breathing and Its Association with Nocturnal Enuresis at the Primary Schools in Saudi Arabia: A Cross-Sectional Study

Alshehri,

Zaki,

Nour

et al. 2023

Children

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The correlation between nocturnal enuresis (NE) and sleep-disordered breathing (SDB) was reported. We aim to determine whether there is an association between NE and SDB in children and to assess the prevalence of SDB and NE in primary school children aged 6–12 years in Saudi Arabia. A cross-sectional observational study was conducted among the caregivers of children aged 6–12 years in all Saudi Arabia regions. The data were gathered through a self-administered online questionnaire. It included demographic information, weight and height, and associated comorbidities, in addition to the weekly frequencies of snoring symptoms and of enuresis, as well as of unrefreshing sleep using Likert-type response scales. Counts and percentages, the mean ± standard deviation, chi-square test, independent samples t-test, and regression analysis were used in the statistical analysis using R v 3.6.3. The questionnaire was completed by 686 respondents. Most respondents did not report any comorbidities in their children (77.1%). Asthma and adenotonsillar hypertrophy were reported in 16.2% and 15.6% of children, respectively. Unrefreshing sleep, mouth breathing at night, snoring, chronic nasal obstruction, and difficulty breathing while asleep were reported once or twice per week in 38%, 34%, 28%, 18%, and 18% of children, respectively. The prevalence of NE was 22.3%, with about 36.6% of children having NE two or more times per week. Significantly, NE was reported in 26.6% of children who slept before 10 PM compared to 19% of children who slept after 10 PM; in 28.6% of children who snored or loudly snored (57.1%) three times or more per week; and in 51.2% and 27.5% of children with difficulty breathing while asleep and who breathed through their mouth at night for one or two nights per week, respectively. A multivariable regression analysis showed that male gender (OR = 1.52, p = 0.010), obesity (OR = 1.24, p = 0.028), early sleeping time (OR = 1.40, p = 0.048), loud snoring for three or more nights per week (OR = 1.54, p = 0.001), difficulty breathing for one or two nights per week (OR = 1.85, p = 0.010), and mouth breathing at night for one or two nights per week (OR = 1.55, p = 0.049) were associated with higher odds of NE. Our study revealed that 22.3% of primary school children reported suffering from NE. SDB is a common problem among children with NE. The exact mechanism that links SDB to the increase in the risk of NE is unknown. Male gender, obesity, early sleeping time, loud snoring, difficulty breathing, and mouth breathing at night are potential independent risk factors of NE in school-age children.

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Sleep Problems and Daytime Sleepiness in Children with Nocturnal Enuresis

Cited by 3 publications

References 19 publications

Sleep Architecture in Valproate-Induced Nocturnal Enuresis in Primary School and Preschool Children

Sleep Architecture in Valproate-Induced Nocturnal Enuresis in Primary School and Preschool Children

Decreased vitamin D levels in children with primary mono-symptomatic nocturnal enuresis

Sleep-Disordered Breathing and Its Association with Nocturnal Enuresis at the Primary Schools in Saudi Arabia: A Cross-Sectional Study

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